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Clinical Trials

NCT05169658 | COMPLETED | PHASE2
42 participants

Mosunetuzumab With or Without Polatuzumab Vedotin and Obinutuzumab for the Treatment of Untreated Indolent B-Cell Non-Hodgkin Lymphoma

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-13
Start Date:
2022-03-23
Completion:
2025-04-02
Conditions
  • Non-Hodgkin Lymphoma
  • Grade 1 Follicular Lymphoma
  • Grade 2 Follicular Lymphoma
  • Grade 3a Follicular Lymphoma
  • Indolent B-Cell Non-Hodgkin Lymphoma
  • Marginal Zone Lymphoma
  • Recurrent Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
  • Refractory Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
Interventions
  • BIOLOGICAL
  • DRUG
  • PROCEDURE
Results Available
NCT05163639 | RECRUITING | EARLY_PHASE1
92 participants

Spinal Cord Associative Plasticity Study

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-13
Start Date:
2021-09-10
Completion:
2026-06-30
Conditions
  • Cervical Spinal Cord Injury
  • Tetraplegia/Tetraparesis
  • Cervical Myelopathy
Interventions
  • PROCEDURE
No Results Yet
NCT05111561 | SUSPENDED | PHASE1
42 participants

Testing the Combination of the Anticancer Drugs ZEN003694 and Binimetinib in Patients With Advanced/Metastatic or Unresectable Solid Tumors With RAS Alterations and Triple Negative Breast Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-13
Start Date:
2022-08-02
Completion:
2027-03-14
Conditions
  • Advanced Malignant Solid Neoplasm
  • Metastatic Malignant Solid Neoplasm
  • Refractory Malignant Solid Neoplasm
  • Triple-Negative Breast Carcinoma
  • Unresectable Malignant Solid Neoplasm
Interventions
  • DRUG
  • PROCEDURE
No Results Yet
NCT05099172 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
370 participants

First in Human Study of BAY2927088 in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Epidermal Growth Factor Receptor (EGFR) and/or Human Epidermal Growth Factor Receptor 2 (HER2)

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-13
Start Date:
2021-10-25
Completion:
2026-11-30
Conditions
  • Advanced Non-small Cell Lung Cancer
  • EGFR Mutation
  • HER2 Mutation
Interventions
  • DRUG
No Results Yet
NCT05092958 | ACTIVE_NOT_RECRUITING | PHASE3
654 participants

Testing the Addition of the Anti-cancer Drug, Cabozantinib, to the Usual Immunotherapy Treatment, Avelumab, in Patients With Metastatic Urothelial Cancer, MAIN-CAV Study

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-13
Start Date:
2022-06-03
Completion:
2026-06-15
Conditions
  • Advanced Bladder Urothelial Carcinoma
  • Advanced Renal Pelvis Urothelial Carcinoma
  • Advanced Ureter Urothelial Carcinoma
  • Advanced Urethral Urothelial Carcinoma
  • Metastatic Bladder Urothelial Carcinoma
  • Metastatic Renal Pelvis Urothelial Carcinoma
  • Metastatic Ureter Urothelial Carcinoma
  • Metastatic Urethral Urothelial Carcinoma
  • Stage III Bladder Cancer AJCC v8
  • Stage III Renal Pelvis and Ureter Cancer AJCC v8
  • Stage III Renal Pelvis Cancer AJCC v8
  • Stage III Ureter Cancer AJCC v8
  • Stage III Urethral Cancer AJCC v8
  • Stage IV Bladder Cancer AJCC v8
  • Stage IV Renal Pelvis and Ureter Cancer AJCC v8
  • Stage IV Renal Pelvis Cancer AJCC v8
  • Stage IV Ureter Cancer AJCC v8
  • Stage IV Urethral Cancer AJCC v8
Interventions
  • DRUG
  • PROCEDURE
  • OTHER
No Results Yet
NCT05063552 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3
430 participants

Testing the Use of Investigational Drugs Atezolizumab and/or Bevacizumab With or Without Standard Chemotherapy in the Second-Line Treatment of Advanced-Stage Head and Neck Cancers

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-13
Start Date:
2023-03-13
Completion:
2027-12-15
Conditions
  • Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
  • Metastatic Head and Neck Squamous Cell Carcinoma
  • Metastatic Hypopharyngeal Squamous Cell Carcinoma
  • Metastatic Laryngeal Squamous Cell Carcinoma
  • Metastatic Lip and Oral Cavity Carcinoma
  • Metastatic Nasal Cavity Squamous Cell Carcinoma
  • Metastatic Nasopharyngeal Squamous Cell Carcinoma
  • Metastatic Pharyngeal Squamous Cell Carcinoma
  • Metastatic Sinonasal Squamous Cell Carcinoma
  • Recurrent Head and Neck Squamous Cell Carcinoma
  • Recurrent Hypopharyngeal Squamous Cell Carcinoma
  • Recurrent Laryngeal Squamous Cell Carcinoma
  • Recurrent Lip and Oral Cavity Squamous Cell Carcinoma
  • Recurrent Nasopharyngeal Squamous Cell Carcinoma
  • Recurrent Pharyngeal Squamous Cell Carcinoma
  • Recurrent Sinonasal Squamous Cell Carcinoma
  • Stage IV Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8
  • Stage IV Hypopharyngeal Carcinoma AJCC v8
  • Stage IV Laryngeal Cancer AJCC v8
  • Stage IV Lip and Oral Cavity Cancer AJCC v8
  • Stage IV Nasopharyngeal Carcinoma AJCC v8
  • Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8
  • Stage IV Sinonasal Cancer AJCC v8
Interventions
  • BIOLOGICAL
  • PROCEDURE
  • DRUG
No Results Yet
NCT05019716 | RECRUITING | PHASE1/PHASE2
36 participants

Testing the Safety and Efficacy of the Addition of a New Anti-cancer Drug, ZEN003694, to Chemotherapy Treatment (Cisplatin and Etoposide or Carboplatin and Paclitaxel) for Adult and Pediatric Patients (12-17 Years) With NUT Carcinoma

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-13
Start Date:
2022-07-13
Completion:
2026-06-30
Conditions
  • Advanced NUT Carcinoma
  • Metastatic NUT Carcinoma
  • Unresectable NUT Carcinoma
Interventions
  • DRUG
  • PROCEDURE
No Results Yet
NCT05005403 | RECRUITING | PHASE1
694 participants

Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid Tumors, Receiving Intravenous Infusion of Azirkitug Alone or in Combination(s) With Budigalimab, Bevacizumab, or Telisotuzumab Adizutecan

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-13
Start Date:
2021-11-01
Completion:
2027-07-31
Conditions
  • Non-Small Cell Lung Cancer
  • Head and Neck Squamous Cell Carcinoma
  • Micro Satellite Stable Colorectal Cancer
  • Gastric/Esophageal Cancer
  • High-Grade Serous Ovarian Cancer
  • Pancreatic Cancer
  • Triple Negative Breast Cancer
Interventions
  • DRUG
No Results Yet
NCT04981509 | RECRUITING | PHASE2
65 participants

Testing of Bevacizumab, Erlotinib, and Atezolizumab in Combination for Advanced-Stage Kidney Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-13
Start Date:
2022-06-10
Completion:
2027-12-31
Conditions
  • Hereditary Leiomyomatosis and Renal Cell Carcinoma
  • Papillary Renal Cell Carcinoma
  • Renal Cell Carcinoma
  • Sporadic Papillary Renal Cell Carcinoma
  • Stage III Renal Cell Cancer AJCC v8
  • Stage IV Renal Cell Cancer AJCC v8
Interventions
  • BIOLOGICAL
  • PROCEDURE
  • DRUG
No Results Yet
NCT04963153 | ACTIVE_NOT_RECRUITING | PHASE1
24 participants

Testing Combination Erdafitinib and Enfortumab Vedotin in Metastatic Bladder Cancer After Treatment With Chemotherapy and Immunotherapy

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-13
Start Date:
2022-07-07
Completion:
2026-12-01
Conditions
  • Locally Advanced Bladder Urothelial Carcinoma
  • Locally Advanced Renal Pelvis Urothelial Carcinoma
  • Locally Advanced Ureter Urothelial Carcinoma
  • Locally Advanced Urethral Urothelial Carcinoma
  • Locally Advanced Urothelial Carcinoma
  • Metastatic Bladder Urothelial Carcinoma
  • Metastatic Renal Pelvis Urothelial Carcinoma
  • Metastatic Ureter Urothelial Carcinoma
  • Metastatic Urethral Urothelial Carcinoma
  • Metastatic Urothelial Carcinoma
  • Recurrent Bladder Urothelial Carcinoma
  • Recurrent Renal Pelvis Urothelial Carcinoma
  • Recurrent Ureter Urothelial Carcinoma
  • Recurrent Urethral Urothelial Carcinoma
  • Recurrent Urothelial Carcinoma
  • Stage IIIB Bladder Cancer AJCC v8
  • Stage IV Bladder Cancer AJCC v8
  • Stage IV Renal Pelvis Cancer AJCC v8
  • Stage IV Ureter Cancer AJCC v8
  • Stage IV Urethral Cancer AJCC v8
Interventions
  • PROCEDURE
  • DRUG
No Results Yet
NCT04956068 | SUSPENDED | PHASE1
25 participants

PIPAC for Peritoneal Metastases

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-13
Start Date:
2021-05-20
Completion:
2026-11-30
Conditions
  • Peritoneal Metastases
Interventions
  • COMBINATION_PRODUCT
No Results Yet
NCT04955808 | SUSPENDED
2400 participants

Biospecimen Collection in Identifying Genetic Changes in Patients With Breast, Prostate, Colorectal, Liver, or Kidney Cancer or Multiple Myeloma Undergoing Surgery

Study Type:
OBSERVATIONAL
Last Updated:
2026-05-13
Start Date:
2017-02-07
Completion:
2026-07-31
Conditions
  • Breast Carcinoma
  • Colon Carcinoma
  • Invasive Carcinoma
  • Kidney Carcinoma
  • Liver Carcinoma
  • Malignant Solid Neoplasm
  • Multiple Myeloma
  • Prostate Carcinoma
Interventions
  • PROCEDURE
  • OTHER
No Results Yet
NCT04929041 | SUSPENDED | PHASE2/PHASE3
427 participants

Testing the Addition of Radiation Therapy to the Usual Treatment (Immunotherapy With or Without Chemotherapy) for Advanced Stage Non-small Cell Lung Cancer Patients Who Are PD-L1 Negative

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-13
Start Date:
2022-10-07
Completion:
2030-12-12
Conditions
  • Lung Adenocarcinoma
  • Lung Adenosquamous Carcinoma
  • Lung Non-Small Cell Carcinoma
  • Stage IIIB Lung Cancer AJCC v8
  • Stage IIIC Lung Cancer AJCC v8
  • Stage IV Lung Cancer AJCC v8
Interventions
  • PROCEDURE
  • BIOLOGICAL
  • OTHER
  • RADIATION
No Results Yet
NCT04929028 | ACTIVE_NOT_RECRUITING | PHASE2
40 participants

Therapy Adapted for High Risk and Low Risk HIV-Associated Anal Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-13
Start Date:
2022-08-09
Completion:
2031-09-15
Conditions
  • AIDS-Related Anal Carcinoma
  • Anal Margin Squamous Cell Carcinoma
  • Anal Non-Keratinizing Squamous Cell Carcinoma
  • Anal Squamous Cell Carcinoma
  • HIV Infection
  • Rectal Squamous Cell Carcinoma
  • Stage II Rectal Cancer AJCC v8
  • Stage IIB Anal Cancer AJCC v8
  • Stage III Anal Cancer AJCC v8
  • Stage III Rectal Cancer AJCC v8
Interventions
  • OTHER
  • DRUG
  • RADIATION
  • PROCEDURE
  • BIOLOGICAL
No Results Yet
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