Clinical Trials

NCT03816345 | RECRUITING | PHASE1

300 participants

Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2019-07-16

Completion:

2028-03-30

Conditions

• Autoimmune Disease
• Crohn Disease
• Dermatomyositis
• Hematopoietic and Lymphoid Cell Neoplasm
• Inflammatory Bowel Disease
• Malignant Solid Neoplasm
• Multiple Sclerosis
• Psoriasis
• Psoriatic Arthritis
• Rheumatoid Arthritis
• Sjogren Syndrome
• Systemic Lupus Erythematosus
• Systemic Scleroderma
• Ulcerative Colitis

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL

No Results Yet

NCT03808610 | TERMINATED | PHASE1/PHASE2

53 participants

Low-Intensity Chemotherapy and Venetoclax in Treating Patients With Relapsed or Refractory B- or T-Cell Acute Lymphoblastic Leukemia

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2019-04-03

Completion:

2026-05-05

Conditions

• Recurrent B Acute Lymphoblastic Leukemia
• Recurrent T Acute Lymphoblastic Leukemia
• Refractory B Acute Lymphoblastic Leukemia
• Refractory T Acute Lymphoblastic Leukemia

Interventions

• DRUG
• BIOLOGICAL

No Results Yet

NCT03795675 | ACTIVE_NOT_RECRUITING | NA

15 participants

CI Following VS Removal or Labyrinthectomy

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2019-01-14

Completion:

2027-01-31

Conditions

• Vestibular Schwannoma
• Meniere Disease

Interventions

• DEVICE

No Results Yet

NCT03775980 | COMPLETED

500 participants

CIRSE Emprint Microwave Ablation Registry

Study Type:

OBSERVATIONAL

Last Updated:

2026-05-13

Start Date:

2019-09-04

Completion:

2023-01-03

Conditions

• Colorectal Neoplasms Malignant
• Neoplasm Metastasis

Interventions

• DEVICE

No Results Yet

NCT03768440 | TERMINATED | PHASE3

34 participants

Continuous Erector Spinae Block Versus Continuous Paravertebral Block

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2019-04-16

Completion:

2025-02-01

Conditions

• Pain, Postoperative

Interventions

• PROCEDURE
• DRUG

Results Available

NCT03757221 | TERMINATED | PHASE2

55 participants

Ixazomib -Daratumumab Without Dexamethasone (IDara) in Elderly Relapse Refractory Multiple Myeloma

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2019-02-07

Completion:

2022-09-15

Conditions

• Multiple Myeloma

Interventions

• COMBINATION_PRODUCT

No Results Yet

NCT03706690 | ACTIVE_NOT_RECRUITING | PHASE3

407 participants

A Study of Durvalumab as Consolidation Therapy in Non-Small Cell Lung Cancer Patients

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2018-11-27

Completion:

2024-06-23

Conditions

• Carcinoma, Non-Small-Cell Lung

Interventions

• DRUG
• OTHER

Results Available

NCT03686124 | RECRUITING | PHASE1/PHASE2

375 participants

ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2019-05-14

Completion:

2028-12-31

Conditions

• Refractory Cancer
• Recurrent Cancer
• Solid Tumor, Adult
• Cancer

Interventions

• BIOLOGICAL
• DRUG
• DEVICE

No Results Yet

NCT03681262 | ACTIVE_NOT_RECRUITING | NA

7 participants

Comparing Long-term Effectiveness of High Frequency and Burst Spinal Cord Stimulation

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2019-08-01

Completion:

2023-12-31

Conditions

• Chronic Pain

Interventions

• DEVICE

Results Available

NCT03672864 | ACTIVE_NOT_RECRUITING | NA

18 participants

Parent Therapist Partnership to Provide Early, Intensive Exercise in Perinatal Stroke

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2019-02-15

Completion:

2026-12-31

Conditions

• Perinatal Stroke

Interventions

• BEHAVIORAL

No Results Yet

NCT03632200 | RECRUITING | NA

60 participants

Nutritional Course of Care After Surgical Treatment at the Patients Affected by a Cancer of the Head and by the Neck

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2019-03-21

Completion:

2027-09-30

Conditions

• Nutrition Disorders
• Head and Neck Cancer

Interventions

• OTHER

No Results Yet

NCT03612310 | RECRUITING

3000 participants

Developing Protocols for Modelling of Genetic Diseases Using Induced Pluripotent Stem Cells

Study Type:

OBSERVATIONAL

Last Updated:

2026-05-13

Start Date:

2018-11-01

Completion:

2028-07-01

Conditions

• Genetic Disease

Interventions

• PROCEDURE

No Results Yet

NCT03606967 | RECRUITING | PHASE2

70 participants

Testing the Addition of an Individualized Vaccine to Durvalumab and Tremelimumab and Chemotherapy in Patients With Metastatic Triple Negative Breast Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2021-04-13

Completion:

2026-12-30

Conditions

• Anatomic Stage IV Breast Cancer AJCC v8
• Invasive Breast Carcinoma
• Metastatic Triple-Negative Breast Carcinoma

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL

No Results Yet

NCT03604978 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

38 participants

Nivolumab and Multi-fraction Stereotactic Radiosurgery With or Without Ipilimumab in Treating Patients With Recurrent Grade II-III Meningioma

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2019-06-17

Completion:

2027-03-19

Conditions

• Grade 2 Meningioma
• Grade 3 Meningioma
• Recurrent Meningioma

Interventions

• PROCEDURE
• BIOLOGICAL
• RADIATION

No Results Yet

NCT03598257 | ACTIVE_NOT_RECRUITING | PHASE2

300 participants

Radiation Therapy With or Without Olaparib in Treating Patients With Inflammatory Breast Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2019-01-18

Completion:

2027-06-01

Conditions

• Breast Inflammatory Carcinoma

Interventions

• PROCEDURE
• DRUG
• RADIATION
• OTHER

No Results Yet

NCT03568292 | SUSPENDED | NA

60 participants

Virtual Reality in Reducing Pain and Anxiety in Cancer Participants Undergoing Painful Procedures

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2022-03-01

Completion:

2026-12-31

Conditions

• Malignant Neoplasm

Interventions

• OTHER
• DEVICE

No Results Yet

NCT03528642 | ACTIVE_NOT_RECRUITING | PHASE1

40 participants

Telaglenastat With Radiation Therapy and Temozolomide in Treating Patients With IDH-Mutated Diffuse Astrocytoma or Anaplastic Astrocytoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2019-05-01

Completion:

2026-09-11

Conditions

• Astrocytoma, IDH-Mutant, Grade 2
• Astrocytoma, IDH-Mutant, Grade 3

Interventions

• OTHER
• RADIATION
• DRUG

No Results Yet

NCT03524989 | COMPLETED | NA

59 participants

The Effect of Hyperbaric Oxygen Therapy on Aerobic and Anaerobic Physical Fitness

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2018-05-15

Completion:

2021-09-15

Conditions

• Healthy
• Athletes

Interventions

• DEVICE

No Results Yet

NCT03524092 | COMPLETED | PHASE3

1328 participants

A Maintenance Study of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2018-10-19

Completion:

2021-11-03

Conditions

• Ulcerative Colitis

Interventions

• DRUG

Results Available

NCT03502733 | ACTIVE_NOT_RECRUITING | PHASE1

64 participants

Testing the Combination of Copanlisib, Nivolumab and Ipilimumab in Patients With Advanced Cancer and Lymphoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2018-08-14

Completion:

2026-07-01

Conditions

• Lymphoma
• Metastatic Malignant Solid Neoplasm
• Recurrent Malignant Solid Neoplasm
• Unresectable Malignant Solid Neoplasm

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL

No Results Yet

NCT03420508 | ACTIVE_NOT_RECRUITING | PHASE2

18 participants

Treating Patients With Melanoma and ALK Alterations With Ensartinib

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2018-01-10

Completion:

2027-01-31

Conditions

• Melanoma

Interventions

• DRUG
• DIAGNOSTIC_TEST

No Results Yet

NCT03389542 | RECRUITING | NA

424 participants

Early Mitral ValvE Repair Versus Watchful Waiting for Asymptomatic SEvere Degenerative Mitral Regurgitation

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2018-04-10

Completion:

2033-04-10

Conditions

• Degenerative Mitral Regurgitation (MR) Due to Leaflet Prolapse

Interventions

• PROCEDURE
• OTHER

No Results Yet

NCT03375307 | SUSPENDED | PHASE2

60 participants

Testing Olaparib in Patients With Advanced or Metastatic (Cancer That Has Spread) Bladder Cancer and Other Genitourinary Tumors With DNA-Repair Genetic Changes

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2020-11-03

Completion:

2026-12-16

Conditions

• Advanced Bladder Carcinoma
• Advanced Genitourinary System Carcinoma
• Metastatic Bladder Carcinoma
• Metastatic Genitourinary System Carcinoma
• Stage III Bladder Cancer AJCC v8
• Stage IV Bladder Cancer AJCC v8

Interventions

• PROCEDURE
• DRUG

No Results Yet

NCT03365089 | WITHDRAWN | NA

0 participants

Collateral Ligation in Failing Fistulas

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2018-05-14

Completion:

2019-12-31

Conditions

• Hemodialysis Access Failure

Interventions

• PROCEDURE

No Results Yet

NCT03347565 | COMPLETED

155 participants

Brain Function in Adolescent Eating Disorders and Healthy Peers

Study Type:

OBSERVATIONAL

Last Updated:

2026-05-13

Start Date:

2017-07-21

Completion:

2024-11-01

Conditions

• Eating Disorder

No Results Yet

NCT03321643 | ACTIVE_NOT_RECRUITING | PHASE1

24 participants

Testing the Addition of an Immunotherapy Agent, Atezolizumab, When Given With the Usual Chemo-Immunotherapy Drug Combination (Rituximab Plus Gemcitabine and Oxaliplatin) for Relapsed/Refractory (That Has Come Back or Not Responded to Treatment) Transformed Diffuse Large B-Cell Lymphoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2018-09-18

Completion:

2026-06-30

Conditions

• Recurrent Diffuse Large B-Cell Lymphoma
• Recurrent Transformed Non-Hodgkin Lymphoma
• Refractory Diffuse Large B-Cell Lymphoma
• Refractory Transformed Non-Hodgkin Lymphoma
• Richter Syndrome
• Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma

Interventions

• DRUG
• PROCEDURE
• BIOLOGICAL

No Results Yet

NCT03317067 | COMPLETED | PHASE3

168 participants

Effects of Dexmedetomidine on Delirium Duration of Non-intubated ICU Patients (4D Trial)

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2017-12-21

Completion:

2021-05-21

Conditions

• Delirium
• Agitation

Interventions

• DRUG
• OTHER

Results Available

NCT03309033 | ACTIVE_NOT_RECRUITING

946 participants

Extended Follow-up of Women Who Received One, Two, and Three Doses of the HPV Vaccine in the Costa Rica Vaccine Trial (CVT), ESCUDDO-CVT Study

Study Type:

OBSERVATIONAL

Last Updated:

2026-05-13

Start Date:

2018-07-02

Completion:

2026-03-05

Conditions

• Human Papillomavirus Infection
• Human Papillomavirus-Related Malignant Neoplasm

Interventions

• PROCEDURE
• OTHER

No Results Yet

NCT03304639 | COMPLETED | PHASE2

9 participants

Testing the Addition of Radiation Therapy to Immunotherapy for Merkel Cell Carcinoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2018-06-12

Completion:

2022-06-07

Conditions

• Advanced Merkel Cell Carcinoma
• Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8
• Clinical Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8
• Metastatic Merkel Cell Carcinoma
• Pathologic Stage III Cutaneous Merkel Cell Carcinoma AJCC v8
• Pathologic Stage IIIA Cutaneous Merkel Cell Carcinoma AJCC v8
• Pathologic Stage IIIB Cutaneous Merkel Cell Carcinoma AJCC v8
• Pathologic Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8

Interventions

• BIOLOGICAL
• RADIATION

Results Available

NCT03256994 | COMPLETED

332 participants

CIRSE Registry for SIR-Spheres in France (CIRT-FR)

Study Type:

OBSERVATIONAL

Last Updated:

2026-05-13

Start Date:

2017-08-01

Completion:

2020-07-31

Conditions

• Liver Cancer

Interventions

• DEVICE
• BEHAVIORAL

No Results Yet

NCT03237780 | ACTIVE_NOT_RECRUITING | PHASE2

72 participants

Atezolizumab With or Without Eribulin Mesylate in Treating Patients With Recurrent Locally Advanced or Metastatic Urothelial Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2018-07-20

Completion:

2027-06-30

Conditions

• Locally Advanced Bladder Urothelial Carcinoma
• Locally Advanced Renal Pelvis Urothelial Carcinoma
• Locally Advanced Ureter Urothelial Carcinoma
• Locally Advanced Urethral Urothelial Carcinoma
• Metastatic Bladder Urothelial Carcinoma
• Metastatic Renal Pelvis Urothelial Carcinoma
• Metastatic Ureter Urothelial Carcinoma
• Metastatic Urethral Urothelial Carcinoma
• Recurrent Bladder Urothelial Carcinoma
• Recurrent Renal Pelvis Urothelial Carcinoma
• Recurrent Ureter Urothelial Carcinoma
• Recurrent Urethral Urothelial Carcinoma
• Stage III Bladder Cancer AJCC v8
• Stage III Renal Pelvis Cancer AJCC v8
• Stage III Ureter Cancer AJCC v8
• Stage III Urethral Cancer AJCC v8
• Stage IV Bladder Cancer AJCC v8
• Stage IV Renal Pelvis Cancer AJCC v8
• Stage IV Ureter Cancer AJCC v8
• Stage IV Urethral Cancer AJCC v8
• Unresectable Bladder Urothelial Carcinoma
• Unresectable Renal Pelvis Urothelial Carcinoma
• Unresectable Ureter Urothelial Carcinoma
• Unresectable Urethral Urothelial Carcinoma

Interventions

• DRUG
• PROCEDURE

No Results Yet

NCT03196427 | COMPLETED | PHASE2

59 participants

Long-term Safety With Vedolizumab Intravenous (IV) in Pediatric Participants With Ulcerative Colitis (UC) or Crohn's Disease (CD)

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2018-07-30

Completion:

2025-04-03

Conditions

• Ulcerative Colitis
• Crohn's Disease

Interventions

• DRUG

Results Available

NCT03141684 | ACTIVE_NOT_RECRUITING | PHASE2

63 participants

Testing Atezolizumab Alone or Atezolizumab Plus Bevacizumab in People With Advanced Alveolar Soft Part Sarcoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2017-04-25

Completion:

2026-10-31

Conditions

• Metastatic Alveolar Soft Part Sarcoma
• Unresectable Alveolar Soft Part Sarcoma

Interventions

• DRUG
• BIOLOGICAL
• PROCEDURE

No Results Yet

NCT03124212 | RECRUITING

700 participants

Cascade Genetic Testing for Hereditary Breast/Ovarian Cancer and Lynch Syndrome in Switzerland

Study Type:

OBSERVATIONAL

Last Updated:

2026-05-13

Start Date:

2017-04-01

Completion:

2035-01-31

Conditions

• Hereditary Breast and Ovarian Cancer
• Lynch Syndrome

Interventions

• OTHER

No Results Yet

NCT03115203 | RECRUITING | NA

60 participants

Morphometric Study of the Muscles of the Skin in MRI 3 Tesla in Patients With Facial Paralysis.

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2016-08-08

Completion:

2027-08-08

Conditions

• Facial Paralysis

Interventions

• OTHER

No Results Yet

NCT03098342 | COMPLETED | NA

27 participants

Comparison of Efficacy and Safety Between Methylene Blue-mediated Photodynamic Therapy and 5% Amorolfine Nail Lacquer for Toenail Onychomycosis Treatment

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2017-06-01

Completion:

2018-12-30

Conditions

• Onychomycosis of Toenail

Interventions

• PROCEDURE
• DRUG

No Results Yet

NCT03086096 | COMPLETED

152 participants

CIRSE Registry for LifePearl Microspheres

Study Type:

OBSERVATIONAL

Last Updated:

2026-05-13

Start Date:

2018-02-02

Completion:

2021-08-31

Conditions

• Colorectal Carcinoma
• Neoplasm Metastasis

Interventions

• DEVICE

No Results Yet

NCT03068442 | ACTIVE_NOT_RECRUITING | PHASE2

45 participants

The Role of Large Artery Plaque Imaging Features in Predicting Inflammation and Cognition

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2017-02-17

Completion:

2030-09-10

Conditions

• Cognitive Impairment
• Carotid Artery Plaque
• Inflammation

Interventions

• DRUG

No Results Yet

NCT03068208 | COMPLETED | NA

15 participants

Efficacy of Methylene Blue Mediated Photodynamic Therapy for Primary Localized Cutaneous Amyloidosis Treatment in Asians

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2022-05-01

Completion:

2023-04-30

Conditions

• Lichen Amyloidosis

Interventions

• PROCEDURE

No Results Yet

NCT03068156 | COMPLETED | NA

15 participants

Efficacy of 308-nm Excimer Laser for Primary Localized Cutaneous Amyloidosis Treatment in Asians

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-13

Start Date:

2022-01-31

Completion:

2023-01-30

Conditions

• Lichen Amyloidosis

Interventions

• RADIATION

No Results Yet