Clinical Trials Updated in 2025

NCT06990711 | RECRUITING | PHASE1

30 participants

A Phase 1 Clinical Trial of Siltuximab for the Treatment of Antibody-Mediated Rejection After Lung Transplantation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2025-11-06
Completion:: 2027-12-30

Conditions

Antibody Mediated Rejection of Lung Transplant

Interventions

DRUG

No Results Yet

NCT06987305 | RECRUITING | PHASE3

820 participants

Intravenous rhTNK-tPA Before Stroke Thrombectomy in the Extended Time Window

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2025-10-21
Completion:: 2027-10-31

Conditions

Stroke, Acute Ischemic

Interventions

DRUG
PROCEDURE

No Results Yet

NCT06965569 | COMPLETED | PHASE1

37 participants

Multiple Ascending Dose Phase 1 Study of ALA-3000

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2025-04-21
Completion:: 2025-12-30

Conditions

Treatment Resistant Depression

Interventions

DRUG

No Results Yet

NCT06964542 | COMPLETED | NA

32 participants

Effect of Supervised in Comparison to Non-supervised Multicomponent Exercise Training on Balance and Quality of Life in Peripheral Diabetic Neuropathy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2024-09-10
Completion:: 2025-05-15

Conditions

Peripheral Diabetic Neuropathy

Interventions

PROCEDURE

No Results Yet

NCT06963606 | RECRUITING | NA

22000 participants

Effectiveness of Computer-Aided Detection Chest X-Ray Screening for Improving Tuberculosis Diagnostic Yield in Chinese Primary Health Care Settings: Study Protocol for a Prospective Cluster Randomized Controlled Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2025-09-01
Completion:: 2027-12-31

Conditions

Tuberculosis (TB)

Interventions

DIAGNOSTIC_TEST
OTHER

No Results Yet

NCT06959238 | COMPLETED | NA

30 participants

Investigation of the Effects of Basic Body Awareness Therapy on Core Muscle Endurance, Posture, Balance, Quality of Life and Body Awareness in Earthquake Victims

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2025-05-01
Completion:: 2025-05-20

Conditions

Earthquake
Core
Posture
Balance
Quality of Life
Body Awareness

Interventions

OTHER

No Results Yet

NCT06958510 | COMPLETED | NA

24 participants

Modified Anatomical Mesh In The Management Of Orbito-Zygomatico-Maxillary Complex Fractures

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2024-10-01
Completion:: 2025-03-01

Conditions

Orbital Fractures
Zygomatic Fractures

Interventions

DEVICE

No Results Yet

NCT06947837 | COMPLETED

200 participants

Study on the Influencing Mechanism and Promoting Strategies of Post-partum Nurses' Work Engagement

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-31
Start Date:: 2025-09-30
Completion:: 2025-12-20

Conditions

Nurses
Postpartum
Work Engagement

No Results Yet

NCT06932536 | COMPLETED | PHASE1

40 participants

The Pharmacokinetics (PK), Safety, Tolerability of SR750 (Formulation F1) in Healthy Volunteers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2025-04-28
Completion:: 2025-07-07

Conditions

Healthy

Interventions

DRUG

No Results Yet

NCT06927024 | RECRUITING | NA

30 participants

Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) in Chronic Kidney Disease (CKD)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2025-10-15
Completion:: 2029-01-31

Conditions

Chronic Kidney Diseases

Interventions

DEVICE

No Results Yet

NCT06910215 | COMPLETED | NA

195 participants

Effect of Elastic Therapeutic Taping on Post-Sternotomy Pain in Coronary Artery Bypass Graft Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2025-01-22
Completion:: 2025-12-24

Conditions

Postoperative Pain
Sternotomy
Pain Management
Coronary Artery Bypass

Interventions

OTHER

No Results Yet

NCT06900179 | ENROLLING_BY_INVITATION | NA

188 participants

The Effectiveness of Augmented Reality Facilitated Education in Promoting Care Management of Malignant Fungating Wounds Among Oncology Nurses

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2024-08-01
Completion:: 2025-03-12

Conditions

Nursing Education

Interventions

OTHER

No Results Yet

NCT06880250 | ENROLLING_BY_INVITATION

100 participants

Efficacy and Safety of Enzyme Replacement Therapy in Patients With Fabry Disease

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-31
Start Date:: 2025-03-24
Completion:: 2027-01-31

Conditions

Fabry Disease

No Results Yet

NCT06860971 | RECRUITING | PHASE3

144 participants

A Study of AL2846 Capsule Versus Placebo in the Treatment of Advanced Radioiodine-Refractory Differentiated Thyroid Carcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2025-04-18
Completion:: 2027-01-31

Conditions

Thyroid Cancer

Interventions

DRUG

No Results Yet

NCT06858878 | ACTIVE_NOT_RECRUITING | PHASE3

1105 participants

Efficacy and Safety of Maridebart Cafraglutide in Adult Participants With Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2025-03-17
Completion:: 2027-01-21

Conditions

Type 2 Diabetes Mellitus (T2DM), Obesity, Overweight

Interventions

DRUG

No Results Yet

NCT06846931 | COMPLETED | NA

90 participants

Comparison of the Efficacy of Shock Wave Therapy and Laser Therapy for Plantar Fasciitis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2025-03-07
Completion:: 2025-12-25

Conditions

Plantar Fasciitis, Chronic

Interventions

OTHER

No Results Yet

NCT06805331 | COMPLETED | NA

46 participants

The Effect of Health Belief Model-Based Pelvic Floor Muscle Exercise Training on Urinary Incontinence and Quality of Life in Female Patients With Multiple Sclerosis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2025-04-09
Completion:: 2025-06-01

Conditions

Multiple Sclerosis
Urinary Incontinence

Interventions

BEHAVIORAL
OTHER

No Results Yet

NCT06783413 | COMPLETED | NA

40 participants

Effects of Laughter Yoga on Fatigue, Sleep Quality and Psychological Well-Being in Patients With Multiple Sclerosis: A Randomized Controlled Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2025-04-15
Completion:: 2025-05-30

Conditions

Multiple Sclerosis
Fatigue
Sleep Quality
Psychological Well-being

Interventions

BEHAVIORAL
OTHER

No Results Yet

NCT06782581 | RECRUITING | NA

186 participants

CARE Study: Cancer, Asian Americans, and Relationship Enrichment

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2024-08-06
Completion:: 2027-01-15

Conditions

Neoplasm

Interventions

BEHAVIORAL

No Results Yet

NCT06770738 | COMPLETED

320 participants

EuroSCORE-II and POSPOM in Cardiac Surgery

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-31
Start Date:: 2025-01-03
Completion:: 2025-10-15

Conditions

Cardiac Disease
Cardiovascular Diseases
Cardiovascular Complication
Anesthesia
Perioperative/Postoperative Complications
Surgery

Interventions

OTHER

No Results Yet

NCT06767150 | RECRUITING | PHASE4

200 participants

StrAtegies For Zoledronic Acid Post-dEnosumab Discontinuation in Postmenopausal oSTeoporosis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2025-10-02
Completion:: 2030-10-31

Conditions

Postmenopausal Osteoporosis

Interventions

DRUG

No Results Yet

NCT06744166 | COMPLETED | NA

156 participants

Effect of Transcutaneous Electrical Nerve Stimulation Based on Wrist-ankle Acupuncture Theory on Postoperative Pain After Video-assisted Thoracoscopic Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2025-02-06
Completion:: 2025-06-20

Conditions

Postoperative Pain
Video-assisted Thoracoscopic Surgery (VATS)

Interventions

DEVICE

No Results Yet

NCT06726876 | RECRUITING | PHASE3

150 participants

Therapeutic Effect of Manuka Honey Oral Rinse in Periodontitis Patients Undergoing Hemodialysis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2024-10-01
Completion:: 2025-12-30

Conditions

Periodontitis
Hemodialysis

Interventions

DIETARY_SUPPLEMENT
DRUG

No Results Yet

NCT06715839 | RECRUITING | NA

400 participants

Target-specific immunoPET Imaging of Digestive System Carcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2024-12-04
Completion:: 2027-09-30

Conditions

Malignancy
Digestive Cancer
Digestive System Neoplasm
Digestive System Carcinoma
Digestive System Cancer
Liver Cancer
Stomach Cancer
Colon Cancer
Rectum Cancer
Pancreatic Cancer
Esophagus Cancer
Gallbladder Carcinoma
Small Intestine Cancer
Appendix Cancer
Bile Duct Carcinoma

Interventions

DRUG

No Results Yet

NCT06713434 | ACTIVE_NOT_RECRUITING | PHASE1

20 participants

Pilot Study of ELK-003 Eye Drops for Treating Ocular Manifestations of Epidermolysis Bullosa

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2024-05-07
Completion:: 2026-06-30

Conditions

Junctional Epidermolysis Bullosa
Epidermolysis Bullosa (EB)
Dystrophic Epidermolysis Bullosa
Recessive Dystrophic Epidermolysis Bullosa

Interventions

BIOLOGICAL

No Results Yet

NCT06710119 | RECRUITING | NA

60 participants

Effect of Custom Dynamic Orthoses on Forefoot Loading

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2025-06-18
Completion:: 2027-12-31

Conditions

Lower Extremity Injuries

Interventions

OTHER

No Results Yet

NCT06706505 | COMPLETED | NA

44 participants

Mindfulness-Based Art Therapy for Nurses: Difficulties in Emotion Regulation, Burnout, and Psychological Flexibility

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2024-12-01
Completion:: 2024-12-05

Conditions

Mental Health Wellness 1
Burnout, Professional

Interventions

BEHAVIORAL

No Results Yet

NCT06699030 | RECRUITING | NA

100 participants

A Strategy for Gallstone Expulsion Through Dietary Therapy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2024-12-24
Completion:: 2026-12-01

Conditions

Gallbladder Stone

Interventions

DRUG
OTHER

No Results Yet

NCT06697405 | COMPLETED

1444 participants

Impact of Cardiopulmonary Bypass Time on Gastrointestinal Complications

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-31
Start Date:: 2024-12-24
Completion:: 2025-12-25

Conditions

Valvular Disease

Interventions

OTHER

No Results Yet

NCT06685406 | COMPLETED

120 participants

The Validity of Thorathic Fluid Content as Non Invasive Predictor on Weaning of Mechanical Ventilation in Critically Ill Patients

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-31
Start Date:: 2024-11-18
Completion:: 2025-11-18

Conditions

Cardiometry
Thorathic Fluid Content
Weaning From Mechanical Ventilation

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT06680089 | RECRUITING | PHASE2

300 participants

CD70-targeted immunoPET Imaging of Kidney Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2024-11-27
Completion:: 2026-11-30

Conditions

Urologic Neoplasms
Urogenital Neoplasms
Kidney Neoplasms
Neoplasms

Interventions

DRUG

No Results Yet

NCT06649682 | SUSPENDED | PHASE1

20 participants

68Ga-NYM096/177Lu-NYM096 in Metastatic ccRCC

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2024-11-21
Completion:: 2026-10-31

Conditions

Clear Cell Renal Cell Carcinoma

Interventions

DRUG

No Results Yet

NCT06600802 | RECRUITING | NA

120 participants

Intrinsic Validity of Molecular Marker(s) Detection on Tissular Tumoral DNA to Predict the Efficacy of 177Lutetium-PSMA-617 (Lu-PSMA) Treatment for Castration-resistant Metastatic Prostate Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2024-10-08
Completion:: 2034-06-30

Conditions

Castration-resistant Metastatic Prostate Cancer
Treated by 177Lutetium-PSMA-617 (Lu-PSMA)

Interventions

BIOLOGICAL

No Results Yet

NCT06597747 | COMPLETED | NA

20 participants

Design Improvements With SONNET 3

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2024-12-16
Completion:: 2025-05-22

Conditions

Hearing Loss, Sensorineural

Interventions

DEVICE

Results Available

NCT06576024 | COMPLETED | PHASE4

392 participants

Immunogenicity and Safety of Inactivated Hepatitis A Vaccine in HIV-infected People

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2023-12-19
Completion:: 2025-04-25

Conditions

Hepatitis A
Immunodeficiency
HIV Infections

Interventions

BIOLOGICAL

No Results Yet

NCT06568718 | COMPLETED | NA

229 participants

Efficacy and Safety of Longidaze in the Treatment of Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2023-03-20
Completion:: 2024-02-09

Conditions

Lower Urinary Tract Symptoms
Prostatic Hyperplasia

Interventions

DRUG

No Results Yet

NCT06567041 | COMPLETED | PHASE1

82 participants

A Research Study of How Safe a New Medicine Called NNC0519 0130 is and to Test Its Effect in People Living With Excess Body Weight With or Without Type 2 Diabetes

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2024-08-07
Completion:: 2025-12-10

Conditions

Diabetes Mellitus, Type 2
Obesity

Interventions

DRUG

No Results Yet

NCT06531499 | RECRUITING | PHASE1

106 participants

A Study of Radiation Dosimetry, Safety, and Tolerability of Extended Lutetium (177Lu) Vipivotide Tetraxetan Treatment in Chemo-naïve Adults With Metastatic Castration-resistant Prostate Cancer: RADIOpharmaceutical DOSimetry Evaluation (RADIODOSE) Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2024-11-11
Completion:: 2028-11-24

Conditions

Metastatic Castration-Resistant Prostate Cancer

Interventions

DRUG

No Results Yet

NCT06524427 | RECRUITING | NA

1124 participants

Robot-Assisted vs. Video-Assisted Lobectomy for NSCLC (RAVAR)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2020-08-25
Completion:: 2030-12-31

Conditions

Non Small Cell Lung Cancer

Interventions

PROCEDURE

No Results Yet

NCT06512558 | RECRUITING | NA

20 participants

Augmented Reality Feasibility for Non-invasive Preoperative Tracking in Breast Cancer Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-31
Start Date:: 2024-11-14
Completion:: 2027-11-01

Conditions

Subclinical Breast Cancer Lesion

Interventions

PROCEDURE

No Results Yet