Clinical Trials Updated in 2025

NCT06821126 | RECRUITING | PHASE1/PHASE2

238 participants

Study Comparing Safety and Immunogenicity of Intranasal COVID-19 Vaccine and mRNA Booster in Healthy Adults

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2025-05-09
Completion:: 2026-10-31

Conditions

Healthy

Interventions

BIOLOGICAL

No Results Yet

NCT06817421 | NOT_YET_RECRUITING | PHASE4

214 participants

Opportunistic Pneumococcal Immunisation Trial in MALnutrition

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2026-01-31
Completion:: 2028-03-31

Conditions

Severe Acute Malnutrition in Childhood
Pneumococcal Disease
Pneumococcal Vaccines
Pneumococcal Infection
Pneumonia in Children

Interventions

BIOLOGICAL

No Results Yet

NCT06799702 | NOT_YET_RECRUITING | NA

50 participants

Trauma-informed, Resilience-based Telehealth Intervention for Improving HIV Prevention and HCV Care for Persons Who Inject Drugs in the Deep South (Pilot Testing: Aim3)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2026-08-01
Completion:: 2028-03-31

Conditions

HIV Pre-exposure Prophylaxis
HEPATITIS C (HCV)
Opioid Use Disorder

Interventions

BEHAVIORAL

No Results Yet

NCT06797817 | NOT_YET_RECRUITING | PHASE3

156 participants

Tributyrin Treatment in Mild Alzheimer Disease: Assessment of Butyrate Effects Via the Gut-Brain

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2026-06-01
Completion:: 2026-09-01

Conditions

Alzheimer Disease (AD)

Interventions

DIETARY_SUPPLEMENT
OTHER

No Results Yet

NCT06786455 | COMPLETED | PHASE2

9 participants

Pharmacokinetics, Pharmacodynamics, Safety, and Preliminary Efficacy of Subcutaneous Injection of SHR-1905 in Adolescent Asthmatic Subjects - an Open-label, Single-dose Phase II Clinical Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2025-01-23
Completion:: 2025-12-03

Conditions

Adolescent Asthma

Interventions

DRUG

No Results Yet

NCT06785272 | RECRUITING | PHASE3

192 participants

Magnesium Trial in Acute Asthma in Emergency Department

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2025-10-08
Completion:: 2027-10-31

Conditions

Asthma

Interventions

DRUG

No Results Yet

NCT06775171 | COMPLETED | NA

270 participants

Impact of Video-Based Pressure Injury Training on Caregivers' Knowledge, Attitudes, Behaviors & Reactions

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2024-01-14
Completion:: 2024-12-14

Conditions

Pressure Injury

Interventions

BEHAVIORAL

No Results Yet

NCT06774027 | RECRUITING

100 participants

Prospective Registry of ADC as First- and Second-line Treatment for Breast Cancer

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-18
Start Date:: 2025-10-08
Completion:: 2030-12-31

Conditions

HER2-negative Breast Cancer
HER2 Negative Breast Carcinoma
Metastatic Breast Cancer
HR+ HER2 Breast Cancer
Metastatic Triple Negative Breast Cancers
Metastatic Triple-Negative Breast Carcinoma

Interventions

PROCEDURE
DRUG
OTHER

No Results Yet

NCT06770491 | COMPLETED | PHASE1

20 participants

A Phase 1 Study of Y-3 in US Healthy Volunteers.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2025-02-04
Completion:: 2025-09-20

Conditions

Safety
Tolerability
Pharmacokinetic Study in Healthy Volunteers

Interventions

DRUG

No Results Yet

NCT06768983 | COMPLETED | NA

5 participants

Fatigue Reduction in Chronic Kidney Disease (CKD)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2025-01-30
Completion:: 2025-09-16

Conditions

Chronic Kidney Diseases
Fatigue

Interventions

BEHAVIORAL

No Results Yet

NCT06748898 | COMPLETED | NA

60 participants

Effect of Transcutaneous Electrical Nerve Stimulation Based on Wrist-ankle Acupuncture Theory on EC50 of Remifentanil Inhibiting Responses to Tracheal Intubation Under General Anesthesia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2025-02-06
Completion:: 2025-11-14

Conditions

Perioperative Analgesia
General Anaesthesia

Interventions

OTHER

No Results Yet

NCT06741514 | ENROLLING_BY_INVITATION

100 participants

A Study of Precice Intramedullary Limb Lengthening System (IMLL) Limb Lengthening Procedures

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-18
Start Date:: 2024-03-25
Completion:: 2026-07-01

Conditions

Limb Length Discrepancy

Interventions

DEVICE

No Results Yet

NCT06736613 | RECRUITING | PHASE2

50 participants

A Study of Circulating Tumor DNA (ctDNA) Testing for People With B-Cell Lymphoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2024-12-11
Completion:: 2027-12-11

Conditions

Diffuse Large B Cell Lymphoma
High-grade B-cell Lymphoma
Stage III High Grade B-Cell Lymphoma
Stage IV High Grade B-Cell Lymphoma
DLBCL - Diffuse Large B Cell Lymphoma
Intravascular Large B-Cell Lymphoma
Diffuse Large B Cell Lymphoma of Breast
Diffuse Large B Cell Lymphoma of Testis
HIV-associated Diffuse Large B Cell Lymphoma
Double Expressor DLBCL

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT06727812 | RECRUITING | PHASE1

206 participants

Multicenter Phase I Study of HRS-6208 in Patients With Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2024-12-17
Completion:: 2027-08-31

Conditions

Solid Tumors

Interventions

DRUG

No Results Yet

NCT06724913 | ACTIVE_NOT_RECRUITING | NA

100 participants

Efficacy and Tolerability of a Specialized Food Products for Dietary Therapeutic and Preventive Nutrition Based on Ice Cream (Ice Cream With Brazzein, Maltitol and Oligofructose; Ice Cream With Brazzein, Erythritol, Maltitol and Inulin) Compared to Standard (Sundae) Ice Cream

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2025-06-01
Completion:: 2025-12-31

Conditions

Non-Alcoholic Steatohepatitis (NASH)
Diabetes Mellitus Type 2 (T2DM)

Interventions

OTHER

No Results Yet

NCT06722378 | RECRUITING | NA

630 participants

A Trial to Improve Family Clinical Note Access and Outcomes for Hospitalized Children

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2025-04-01
Completion:: 2029-04-30

Conditions

Hospitalized Child
Pediatric Patient Safety
Medical Errors
Parental Engagement in Care
Inpatient Pediatric Care

Interventions

OTHER

No Results Yet

NCT06720519 | COMPLETED

170 participants

Molecular Panel Evaluation for Diagnosis of Infections of the Central Nervosous System

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-18
Start Date:: 2024-04-17
Completion:: 2024-10-17

Conditions

Infections Nervous System

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT06717867 | RECRUITING | PHASE2

200 participants

Long-Term PEA Safety Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2025-01-22
Completion:: 2027-06-30

Conditions

Healthy
Safety

Interventions

DIETARY_SUPPLEMENT
OTHER

No Results Yet

NCT06715462 | WITHDRAWN | PHASE3

0 participants

Efficacy and Safety of the N0750 Compared to Monotherapies in the Treatment of Painful Diabetic Peripheral Neuropathy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2026-04-30
Completion:: 2028-03-31

Conditions

Painful Diabetic Peripheral Neuropathy (PDPN)

Interventions

DRUG

No Results Yet

NCT06686576 | RECRUITING | PHASE3

363 participants

A Study of Neoadjuvant QL1706 in Participants With Untreated dMMR/MSI-H Resectable Colon Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2024-12-12
Completion:: 2030-12-31

Conditions

Colon Cancer

Interventions

DRUG

No Results Yet

NCT06684470 | RECRUITING | EARLY_PHASE1

20 participants

Novel Pilot Study to Treat Symptoms of IBS With Diarrhea Using Combination Therapy of a Low-FODMAP Diet and a Neuromodulator

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2024-12-19
Completion:: 2026-12-19

Conditions

IBS - Irritable Bowel Syndrome
Diarrhea

Interventions

DRUG
OTHER

No Results Yet

NCT06680050 | RECRUITING | PHASE2

21 participants

Phase II Study of Radiotherapy Followed by Durvalumab and Ceralasertib in Stage III NSCLC Patients With Thoracic Relapses +/- Oligometastases After PACIFIC Regimen

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2025-08-07
Completion:: 2028-06-30

Conditions

Non Small Cell Lung Cancer NSCLC

Interventions

DRUG
RADIATION

No Results Yet

NCT06672484 | ACTIVE_NOT_RECRUITING

100 participants

Walking Fatigability and Brain Activity in People With Multiple Sclerosis

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-18
Start Date:: 2024-05-22
Completion:: 2025-09-13

Conditions

Multiple Sclerosis
Healthy

No Results Yet

NCT06651463 | NOT_YET_RECRUITING | NA

50 participants

Evaluation of the Feasibility of Camera Measurement of Colorimetric Parameters of the Brain During Neurosurgery Operations: Tissue Oximetry and Endogenous or Induced Fluorescence

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2026-01-01
Completion:: 2028-01-01

Conditions

Brain Diseases

Interventions

OTHER

No Results Yet

NCT06641921 | COMPLETED | NA

330 participants

Strategy TO Prevent Decompensated Heart Failure

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2024-05-01
Completion:: 2025-10-01

Conditions

Heart Failure
Remote Monitoring

Interventions

DEVICE

No Results Yet

NCT06636279 | COMPLETED | NA

80 participants

A Randomized Study of Gas Bubble Technique in Cataract Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2024-10-10
Completion:: 2025-02-10

Conditions

Corneal Endothelial Damage Following the Hard Nuclear Cataract Surgery

Interventions

PROCEDURE

No Results Yet

NCT06632756 | COMPLETED | NA

16 participants

Positive Psychology for Smoking Cessation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2024-10-10
Completion:: 2025-09-30

Conditions

Mental Illness
Tobacco Dependence

Interventions

BEHAVIORAL

No Results Yet

NCT06623019 | COMPLETED

413 participants

Study of the Validity and Reliability of Two Digital Dynamometers in Older People

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-18
Start Date:: 2024-12-16
Completion:: 2025-03-31

Conditions

Sarcopenia
Old Age; Debility
Frailty

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT06609889 | RECRUITING | PHASE1/PHASE2

10 participants

A Safety and Efficacy of Intrathecally Administered ION283 in Patients With Lafora Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2024-12-03
Completion:: 2027-10-31

Conditions

Lafora Disease

Interventions

GENETIC

No Results Yet

NCT06604949 | ACTIVE_NOT_RECRUITING | PHASE1

12 participants

A Study of Single Dose of LP-003 in Healthy Adult Subjects

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2024-10-23
Completion:: 2026-11-30

Conditions

Chronic Spontaneous Urticaria

Interventions

DRUG

No Results Yet

NCT06595927 | COMPLETED | NA

29 participants

Clinical Signs and Changes in Cervical Muscles Activity Evaluated by Magnetic Resonance Imaging During an Endurance Test

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2024-11-01
Completion:: 2025-01-31

Conditions

Neck Pain
Motor Activity

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT06593847 | COMPLETED | NA

1542 participants

Multisite Virtual Reality Intervention for Speech Anxiety

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2024-10-08
Completion:: 2025-07-23

Conditions

Public Speaking
Speech Anxiety

Interventions

BEHAVIORAL

No Results Yet

NCT06590480 | NO_LONGER_AVAILABLE

An Expanded Access Program for VO (RP1) in Combination With Nivolumab in Patients With Advanced Melanoma

Study Type:: EXPANDED_ACCESS
Last Updated:: 2025-12-18

Conditions

Advanced Melanoma

Interventions

BIOLOGICAL

No Results Yet

NCT06583018 | ACTIVE_NOT_RECRUITING | NA

84 participants

Mindfulness-based Lifestyle Modification Programme for Caregivers of People With Neurodegenerative Disorders: A Pilot Randomised Controlled Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2024-09-06
Completion:: 2026-01-31

Conditions

Caregiver

Interventions

BEHAVIORAL
DEVICE

No Results Yet

NCT06579092 | COMPLETED | PHASE2

310 participants

Effects of AZD5004 in Adults Who Are Living With Obesity or Overweight With at Least 1 Weight-related Comorbidity

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2024-10-08
Completion:: 2025-11-21

Conditions

Obesity or Overweight

Interventions

DRUG

No Results Yet

NCT06560333 | WITHDRAWN | PHASE3

0 participants

iSGLT2 Inhibitor and a iDPP -4 Inhibitor in Treatment of Type 2 Diabetes Mellitus in Patients Treated With Metformin (TRIAD)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2026-11-30
Completion:: 2027-04-30

Conditions

Diabetes Mellitus, Type 2

Interventions

DRUG

No Results Yet

NCT06560229 | ACTIVE_NOT_RECRUITING | NA

400 participants

Giving Resources to lOw-income Children to Enhance RecoverY

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2024-09-27
Completion:: 2026-07-31

Conditions

Discharged Pediatric Patients and Their Families

Interventions

OTHER

No Results Yet

NCT06556160 | COMPLETED | NA

19 participants

Fundamental and Clinical Study of Cochlear Synaptopathy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2023-03-21
Completion:: 2025-07-16

Conditions

Hearing Loss

Interventions

PROCEDURE

No Results Yet

NCT06551038 | RECRUITING | NA

240 participants

Evaluating Primary Suicide Prevention in Adolescents With Risk Factors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2025-03-11
Completion:: 2027-05-30

Conditions

Suicide Prevention

Interventions

BEHAVIORAL

No Results Yet

NCT06545058 | COMPLETED

2086 participants

Safety Profile of Ropivacaine in Dorsal Penile Nerve Block for Male Circumcision: a Large Cohort Study in Children

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-18
Start Date:: 2000-01-01
Completion:: 2021-12-31

Conditions

Pain
Necrosis

Interventions

PROCEDURE

No Results Yet