Clinical Trials Updated in 2025

NCT05056376 | COMPLETED | NA

368 participants

Effectiveness and Cost-Effectiveness of Fully-Automated Digital vs. Human Coach-Based Diabetes Prevention Programs

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2021-10-01
Completion:: 2024-12-16

Conditions

PreDiabetes
Hyperglycemia
Glucose, High Blood
Overweight
Prediabetic State
Impaired Glucose Tolerance
Obesity
Weight Loss
Lifestyle, Healthy
Lifestyle Risk Reduction
Lifestyle, Sedentary

Interventions

BEHAVIORAL

Results Available

NCT05005026 | RECRUITING | NA

250 participants

Virtual Walking Intervention for Neuropathic Pain in Spinal Cord Injury

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2021-11-23
Completion:: 2026-09-30

Conditions

Spinal Cord Injuries
Neuropathic Pain

Interventions

OTHER

No Results Yet

NCT04977986 | COMPLETED | PHASE3

215 participants

Clinical Study of Cannabidiol in Children, Adolescents, and Young Adults With Fragile X Syndrome

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2021-09-13
Completion:: 2025-08-29

Conditions

Fragile X Syndrome

Interventions

DRUG

No Results Yet

NCT04975841 | COMPLETED | NA

9 participants

Inclusion Body Myositis Treatment With Celution Processed Adipose Derived Regenerative Cells

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2022-03-10
Completion:: 2025-09-26

Conditions

Inclusion Body Myositis

Interventions

DEVICE

No Results Yet

NCT04971889 | ACTIVE_NOT_RECRUITING | NA

291 participants

Diabetes Medical Nutrition Therapy in Southeastern African American Women

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2021-08-03
Completion:: 2025-10-31

Conditions

Type 2 Diabetes

Interventions

BEHAVIORAL

No Results Yet

NCT04970810 | COMPLETED | NA

512 participants

My Diabetes, My Community

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2021-07-29
Completion:: 2024-10-31

Conditions

Type 2 Diabetes

Interventions

BEHAVIORAL

Results Available

NCT04964895 | COMPLETED

50 participants

Sexual Quality of Patients After Bladder Cancer Cystectomy

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-17
Start Date:: 2021-09-20
Completion:: 2022-09-01

Conditions

Sexual Dysfunction

Interventions

OTHER

No Results Yet

NCT04945317 | ENROLLING_BY_INVITATION | NA

349 participants

ROSE for Improved Molecular Marker Testing Via EBUS

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2021-05-14
Completion:: 2026-12-31

Conditions

Non-small Cell Lung Cancer (NSCLC)

Interventions

OTHER

No Results Yet

NCT04938245 | RECRUITING

15 participants

Improving Spinal Cord Stimulation With ECAPS

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-17
Start Date:: 2021-08-18
Completion:: 2026-12-31

Conditions

Chronic Pain

Interventions

DEVICE

No Results Yet

NCT04889872 | RECRUITING | NA

2250 participants

PROGRESS: Management of Moderate Aortic Stenosis by Clinical Surveillance or TAVR

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2021-10-12
Completion:: 2029-06-30

Conditions

Aortic Stenosis, Calcific
Aortic Valve Stenosis

Interventions

DEVICE

No Results Yet

NCT04864275 | COMPLETED

2500 participants

Personalized Prediction of Persistent Postsurgical Pain

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-17
Start Date:: 2021-09-10
Completion:: 2025-09-30

Conditions

Pain, Postoperative

No Results Yet

NCT04863885 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

46 participants

Combination of Ipi/Nivo Plus Sacituzumab Govitecan in Metastatic Cisplatin Ineligible Urothelial Carcinoma Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2021-04-30
Completion:: 2025-09-12

Conditions

Metastatic Urothelial Carcinoma

Interventions

DRUG

No Results Yet

NCT04852354 | RECRUITING

500 participants

Tissue Collection for Drug Screening and Bioanalysis

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-17
Start Date:: 2020-07-22
Completion:: 2029-07-22

Conditions

Central Nervous System Tumor

No Results Yet

NCT04851184 | TERMINATED | NA

28 participants

Dose of Vestibular Rehabilitation for Vestibular Hypofunction

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2021-03-22
Completion:: 2024-09-01

Conditions

Vestibular Disorder

Interventions

DEVICE
BEHAVIORAL

Results Available

NCT04797091 | COMPLETED

500 participants

Kidney in Coronavirus Disease 2019 Registry

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-17
Start Date:: 2020-04-20
Completion:: 2025-08-31

Conditions

Corona Virus Infection
SARS-CoV 2

Interventions

OTHER

No Results Yet

NCT04742491 | COMPLETED | PHASE2/PHASE3

304 participants

Pre-Exposure Prophylaxis for Transgender Women in the US and South America

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2021-03-26
Completion:: 2024-08-16

Conditions

HIV Prevention

Interventions

DRUG

Results Available

NCT04722978 | RECRUITING | PHASE3

228 participants

Standard Chemotherapy Plus Moxifloxacin as First-line Treatment for Metastatic Triple-negative Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2021-04-20
Completion:: 2026-06-30

Conditions

Triple Negative Breast Cancer

Interventions

DRUG

No Results Yet

NCT04700488 | SUSPENDED | NA

36 participants

Magnetic Resonance Imaging (MRI) to Predict Outcomes of Pancreatic Ductal Adenocarcinoma (PDAC)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2022-05-19
Completion:: 2026-01-31

Conditions

PDAC - Pancreatic Ductal Adenocarcinoma

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04688658 | TERMINATED | PHASE1/PHASE2

13 participants

Duvelisib in Combination With Nivolumab in Patients With Advanced Unresectable Melanoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2021-10-06
Completion:: 2024-02-22

Conditions

Unresectable Melanoma

Interventions

DRUG

Results Available

NCT04680481 | COMPLETED | NA

9 participants

Non-Invasive Brain Stimulation to Control Large-Scale Brain Networks

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2020-11-01
Completion:: 2025-09-01

Conditions

Working Memory

Interventions

DEVICE

No Results Yet

NCT04666077 | COMPLETED | NA

100 participants

Music Therapy Experiences in Patients With Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2019-08-27
Completion:: 2025-07-15

Conditions

Alzheimer's Disease
Mild Cognitive Impairment

Interventions

BEHAVIORAL
OTHER

No Results Yet

NCT04647331 | RECRUITING

150 participants

Betalactam Pharmacokinetics in Endocarditis Patients

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-17
Start Date:: 2021-06-01
Completion:: 2025-12-31

Conditions

Infective Endocarditis

No Results Yet

NCT04636801 | TERMINATED | PHASE3

4710 participants

A 52-week, Placebo-controlled Study to Evaluate the Efficacy and Safety of 2 Doses of CHF6001 DPI (Tanimilast), as add-on to Maintenance Triple Therapy in Subjects With COPD and Chronic Bronchitis (PILASTER)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2021-07-14
Completion:: 2025-10-31

Conditions

Chronic Obstructive Pulmonary Disease

Interventions

DRUG

No Results Yet

NCT04628481 | TERMINATED | PHASE2

141 participants

A Study of Oral Ladarixin in Recent Onset Type 1 Diabetes and a Low Residual β-cell Function

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2021-01-12
Completion:: 2025-03-31

Conditions

Recent Onset type1 Diabetes

Interventions

DRUG

No Results Yet

NCT04618211 | COMPLETED | PHASE2

74 participants

Dose-ranging Study of Oral PHA-022121 for Acute Treatment of Angioedema Attacks in Patients With Hereditary Angioedema

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2021-02-03
Completion:: 2022-09-23

Conditions

Hereditary Angioedema
Hereditary Angioedema Type I
Hereditary Angioedema Type II
Hereditary Angioedema Types I and II
Hereditary Angioedema Attack
Hereditary Angioedema With C1 Esterase Inhibitor Deficiency
Hereditary Angioedema - Type 1
Hereditary Angioedema - Type 2
C1 Esterase Inhibitor Deficiency
C1 Inhibitor Deficiency

Interventions

DRUG

Results Available

NCT04594798 | ACTIVE_NOT_RECRUITING | PHASE2

39 participants

A Study of Polatuzumab Vedotin, Rituximab and Dose Attenuated CHP in Older Patients With DLBCL

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2021-09-20
Completion:: 2026-07-31

Conditions

DLBCL
Lymphoma, B-Cell

Interventions

DRUG

No Results Yet

NCT04586699 | ACTIVE_NOT_RECRUITING | NA

50 participants

Meditation Accelerated Brain Stimulation for Depression

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2021-07-15
Completion:: 2025-04-15

Conditions

Depression

Interventions

DEVICE

No Results Yet

NCT04543877 | COMPLETED | EARLY_PHASE1

60 participants

WHNRC (Western Human Nutrition Research Center) Fiber Intervention Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2022-09-27
Completion:: 2025-06-11

Conditions

Inflammation
Vaccine
Intestinal Permeability
Typhoid Fever

Interventions

DIETARY_SUPPLEMENT
BIOLOGICAL

No Results Yet

NCT04536168 | WITHHELD

[Trial of device that is not approved or cleared by the U.S. FDA]

Last Updated:: 2025-12-17

No Results Yet

NCT04534010 | TERMINATED | NA

6 participants

Decellularized, Whole Donor Nipple-Areola Complex Reconstruction Grafts

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2021-04-28
Completion:: 2024-11-21

Conditions

Breast Cancer

Interventions

DEVICE

Results Available

NCT04532177 | ACTIVE_NOT_RECRUITING | NA

15 participants

Stereotactic Body Radiation Therapy (SBRT) for Invasive Breast Cancer Patients Not Undergoing Definitive Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2020-08-19
Completion:: 2027-08-31

Conditions

Breast Cancer

Interventions

RADIATION

No Results Yet

NCT04508907 | ACTIVE_NOT_RECRUITING | PHASE4

200 participants

A Study to Evaluate Preemptive Therapy in Hepatitis C (HCV) Organ Transplant Recipients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2020-09-10
Completion:: 2025-11-01

Conditions

Hepatitis C
Kidney Transplant; Complications
Heart Transplant Infection

Interventions

DRUG

No Results Yet

NCT04458779 | COMPLETED | NA

71 participants

Continuous Positive Airway Pressure on Acute Stroke and Obstructive Sleep Apnea

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2020-07-09
Completion:: 2024-12-31

Conditions

Stroke, Acute
Obstructive Sleep Apnea

Interventions

DEVICE

No Results Yet

NCT04414930 | COMPLETED | PHASE2

68 participants

Pharmacologic Augmentation of Targeted Cognitive Training in Schizophrenia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2020-11-09
Completion:: 2024-12-30

Conditions

Schizophrenia
Schizoaffective Disorder

Interventions

DRUG

Results Available

NCT04414111 | ACTIVE_NOT_RECRUITING

180 participants

Highly Suppressive Treg in Delayed and Slow Graft Function After Kidney Transplantation

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-17
Start Date:: 2020-12-07
Completion:: 2026-07-31

Conditions

DGF
Kidney Transplant; Complications

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04396821 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

150 participants

A Trial to Evaluate Safety and Tolerability of TST001 in Advanced or Metastatic Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2020-05-28
Completion:: 2026-05-30

Conditions

Advanced Cancer
Gastric Cancer
Gastroesophageal-junction Cancer
Pancreatic Cancer

Interventions

DRUG

No Results Yet

NCT04394325 | COMPLETED | NA

80 participants

Digi-Do - a Digital Information Tool to Help Patients Diagnosed With Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2020-09-01
Completion:: 2022-06-01

Conditions

Breast Cancer

Interventions

BEHAVIORAL

No Results Yet

NCT04392401 | RECRUITING

200 participants

COVID-19 - Study of the Kinetics of the Immune Response During the Intensive Care Unit Stay in Adult Patients Infected With SARS-CoV-2: Multicentric Non Interventional Study

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-17
Start Date:: 2020-05-11
Completion:: 2026-04-30

Conditions

Intensive Care Unit
SARS-Cov-2

Interventions

BIOLOGICAL

No Results Yet

NCT04375514 | TERMINATED | PHASE1/PHASE2

43 participants

Study of ARO-ENaC in Healthy Volunteers and in Patients With Cystic Fibrosis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2020-07-30
Completion:: 2021-05-09

Conditions

Cystic Fibrosis, Pulmonary

Interventions

DRUG

Results Available

NCT04369560 | RECRUITING | EARLY_PHASE1

42 participants

Virtual Histology of the Bladder Wall for Bladder Cancer Staging

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-17
Start Date:: 2025-05-23
Completion:: 2028-01-30

Conditions

Urinary Bladder Neoplasms

Interventions

DIAGNOSTIC_TEST
DRUG

No Results Yet