Clinical Trials Updated in 2025

NCT05555615 | TERMINATED | PHASE2/PHASE3

209 participants

Extension Study of Pimavanserin in Irritability Associated With Autism Spectrum Disorder

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2022-11-02
Completion:: 2025-02-14

Conditions

Irritability Associated With Autism Spectrum Disorder

Interventions

DRUG

Results Available

NCT05533983 | RECRUITING | NA

50 participants

FMT With Nivolumab in Patients With Advanced Solid Cancers Who Have Progressed During Anti-PD-(L)1 Therapy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2023-03-08
Completion:: 2026-08-19

Conditions

Solid Carcinoma

Interventions

OTHER

No Results Yet

NCT05518773 | COMPLETED

34 participants

Mechanisms and Treatment of Exercise Intolerance and Persistent Fatigue in Spinal Muscular Atrophy

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-03
Start Date:: 2022-12-15
Completion:: 2025-11-14

Conditions

Spinal Muscular Atrophy

Interventions

OTHER

No Results Yet

NCT05517421 | COMPLETED | PHASE3

114 participants

Study to Assess Batoclimab in Participants With Active Thyroid Eye Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2022-11-23
Completion:: 2025-11-02

Conditions

Thyroid Eye Disease

Interventions

DRUG

No Results Yet

NCT05516940 | COMPLETED

250 participants

A Study of the Impact of Different Delivery Modes on Specific Macronutrient Components in Human Milk

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-03
Start Date:: 2022-05-06
Completion:: 2023-07-30

Conditions

Healthy

Interventions

OTHER

No Results Yet

NCT05478031 | TERMINATED | PHASE2

14 participants

A Phase 2a Study to Investigate REM0046127 in Mild to Moderate Alzheimer's Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2022-06-07
Completion:: 2024-06-04

Conditions

Alzheimer Disease

Interventions

DRUG

No Results Yet

NCT05471245 | COMPLETED | NA

110 participants

AnGiographic Performance With A Sirolimus-elutiNG Balloon in the TrEatment of De Novo CoronaRy Artery Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2023-05-23
Completion:: 2025-10-08

Conditions

Coronary Restenosis

Interventions

DEVICE

No Results Yet

NCT05466201 | COMPLETED | PHASE2/PHASE3

118 participants

The Use of Eltrombopag Post HSCT in BMFD

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2022-10-22
Completion:: 2025-07-31

Conditions

Stem Cell Transplant Complications

Interventions

DRUG

No Results Yet

NCT05452304 | COMPLETED | PHASE1

112 participants

AZD7798 Safety, Tolerability, and Pharmacokinetics After a Single Ascending and Repeat Dose Administrations to Healthy Subjects, and Patients With Crohn's Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2022-07-12
Completion:: 2024-11-14

Conditions

Healthy Subjects
Crohns Disease

Interventions

BIOLOGICAL

No Results Yet

NCT05444205 | ACTIVE_NOT_RECRUITING | NA

24000 participants

The Pittsburgh Study Early Childhood

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2020-06-02
Completion:: 2030-12-31

Conditions

Child Development
Child Language
Child Behavior Problem
Parenting
Parent Child Abuse

Interventions

BEHAVIORAL

No Results Yet

NCT05443737 | RECRUITING | PHASE3

2800 participants

Evaluation of a Telehealth Oncofertility Care Intervention in Adolescent and Young Adult Cancer Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2022-01-01
Completion:: 2027-08-31

Conditions

Cancer
Fertility Preservation

Interventions

BEHAVIORAL

No Results Yet

NCT05435690 | ACTIVE_NOT_RECRUITING | NA

126 participants

Evaluation of a New Navigation System in Computer-assisted Total Knee Arthroplasty

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2023-01-06
Completion:: 2026-05-31

Conditions

Gonarthrosis

Interventions

DEVICE

No Results Yet

NCT05427396 | TERMINATED | PHASE1

31 participants

A Phase I Clinical Study of Recombinant Humanized Anti-BTLA Monoclonal Antibody (JS004) Injection Combined With Toripalimab Injection in Patients With Advanced Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2022-07-28
Completion:: 2024-01-15

Conditions

Liver Cancer, Esophageal Squamous Cell Carcinoma, Gastric Adenocarcinoma, Cervical Cancer, MSI-H Colorectal Cancer

Interventions

DRUG

No Results Yet

NCT05417841 | COMPLETED | NA

218 participants

Safety and Efficacy of Insulin Degludec/Insulin Aspart in Patients With T2DM

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2023-03-23
Completion:: 2025-08-15

Conditions

Type 2 Diabetes Mellitus

Interventions

DRUG

No Results Yet

NCT05404048 | ACTIVE_NOT_RECRUITING | PHASE2

20 participants

PD-L1 PET-imaging During CAR T-cell Therapy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2022-05-18
Completion:: 2025-12-31

Conditions

Large B-cell Lymphoma

Interventions

OTHER

No Results Yet

NCT05393713 | TERMINATED | PHASE1

3 participants

Intra-Lymphatic STI-3031 Using the Sofusa DoseConnect Device for Treatment of In-Transit Melanoma, The Sofusa-2 Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2022-10-17
Completion:: 2025-02-16

Conditions

Clinical Stage III Cutaneous Melanoma AJCC v8
Melanoma
Metastatic Melanoma
Recurrent Metastatic Melanoma

Interventions

BIOLOGICAL
PROCEDURE

No Results Yet

NCT05343286 | RECRUITING | NA

900 participants

Biological & Fonctional Signatures for Muscle Failures, Aged People & Personalized Physical Activity

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2022-04-29
Completion:: 2027-04-15

Conditions

Elderly

Interventions

PROCEDURE
OTHER
BEHAVIORAL

No Results Yet

NCT05335239 | COMPLETED | NA

194 participants

Domiciliary Professional Oral Care for Dependent Older Adults

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2021-12-06
Completion:: 2023-12-01

Conditions

Dental Caries of Root Surface
Aging

Interventions

OTHER

No Results Yet

NCT05311774 | COMPLETED | NA

400 participants

Efficacy of Duloxetine in Conjunction With Tramadol for Chronic Cancer Pain

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2022-04-01
Completion:: 2025-10-01

Conditions

Cancer Pain

Interventions

DRUG

No Results Yet

NCT05276596 | COMPLETED | PHASE3

500 participants

Evaluation of the Early Use of Norepinephrine in Major Abdominal Surgery on Postoperative Organ Dysfunction

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2021-11-17
Completion:: 2024-12-17

Conditions

Norepinephrine
Hypotension
Anesthesiology
Major Abdominal Surgery

Interventions

DRUG

No Results Yet

NCT05274750 | COMPLETED | PHASE3

276 participants

Efficacy and Safety of Depemokimab (GSK3511294) in Participants With Chronic Rhinosinusitis With Nasal Polyps

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2022-04-22
Completion:: 2024-07-30

Conditions

Nasal Polyps

Interventions

BIOLOGICAL
DRUG

Results Available

NCT05224973 | ACTIVE_NOT_RECRUITING | NA

30 participants

Fine Motor Skills and Post-Stroke Swallowing

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2022-11-23
Completion:: 2025-05-23

Conditions

Stroke

Interventions

BEHAVIORAL

No Results Yet

NCT05190770 | COMPLETED | PHASE2

18 participants

A Study of Oleogel-S10 Gel for the Treatment of Radiation Dermatitis in People With Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2021-12-15
Completion:: 2024-08-27

Conditions

Breast Cancer
Breast Cancer Stage
Breast Cancer Stage I
Breast Cancer Stage II
Breast Cancer Stage III
Breast Cancer Stage IV

Interventions

DRUG

Results Available

NCT05179577 | NOT_YET_RECRUITING | PHASE3

442 participants

A Study to Investigate Arbaclofen ER Tablets for the Treatment of Spasticity in Patients With Multiple Sclerosis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2027-01-31
Completion:: 2028-01-31

Conditions

Spasticity

Interventions

DRUG

No Results Yet

NCT05175300 | RECRUITING | NA

100 participants

Interest of a Highly Cross-linked Polyethylene Acetabular Component Doped With Vitamin E in Total Hip Arthroplasty of the Young and Active Subject

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2023-03-24
Completion:: 2032-03-31

Conditions

Hip Arthropathy

Interventions

DEVICE

No Results Yet

NCT05169190 | ACTIVE_NOT_RECRUITING | NA

410 participants

Stellate Ganglion Block for PTSD

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2022-11-17
Completion:: 2025-09-30

Conditions

Post-traumatic Stress Disorder

Interventions

PROCEDURE

No Results Yet

NCT05134948 | COMPLETED | PHASE1/PHASE2

24 participants

A Study to Assess Relatlimab and Nivolumab Fixed-dose Combination in Chinese Participants With Advanced Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2021-11-30
Completion:: 2025-09-01

Conditions

Advanced Solid Tumors

Interventions

DRUG

No Results Yet

NCT05106036 | RECRUITING | NA

4000 participants

Preventing Cognitive Decline by Reducing BP Target Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2022-07-11
Completion:: 2026-08-31

Conditions

Cognitive Decline
Blood Pressure
Hypertension

Interventions

OTHER

No Results Yet

NCT05076682 | RECRUITING | PHASE2

80 participants

Reverse Triple Negative Immune Resistant Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2022-06-30
Completion:: 2026-12-31

Conditions

Triple-negative Breast Cancer

Interventions

DRUG

No Results Yet

NCT05064111 | SUSPENDED

100 participants

Utility of Adding MR Fusion to Standard US Guided Prostate Biopsy

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-03
Start Date:: 2026-11-01
Completion:: 2027-11-01

Conditions

Prostate Cancer
Prostate Adenocarcinoma

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT05055206 | COMPLETED | NA

12 participants

Study of Lymphatic Drainage Mapping in Oropharyngeal Cancers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2021-09-13
Completion:: 2023-10-23

Conditions

Oropharynx Cancer

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT05051384 | ACTIVE_NOT_RECRUITING | NA

22 participants

Superb Microvascular Intraocular Tumor Imaging Study (SMITIS)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2022-04-27
Completion:: 2023-04-27

Conditions

Ocular Tumor

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT05032066 | TERMINATED | PHASE2

153 participants

A Multicenter Trial to Evaluate the Efficacy, Safety and Tolerability of HZN-825 in Subjects With Idiopathic Pulmonary Fibrosis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2022-01-20
Completion:: 2024-07-22

Conditions

Idiopathic Pulmonary Fibrosis

Interventions

DRUG

Results Available

NCT04982588 | ACTIVE_NOT_RECRUITING | NA

52 participants

Evolut PRO China Clinical Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2021-07-17
Completion:: 2023-03-17

Conditions

Severe, Symptomatic Aortic Stenosis

Interventions

DEVICE

Results Available

NCT04978129 | COMPLETED | NA

162 participants

Enhancing Quality in Protective Strategies

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2023-08-15
Completion:: 2024-11-01

Conditions

Health Risk Behaviors
Risk Reduction Behavior

Interventions

BEHAVIORAL

Results Available

NCT04963946 | ACTIVE_NOT_RECRUITING | PHASE2

160 participants

STop and Restart Acalabrutinib In fRail Patients With Previously Untreated Chronic Lymphocytic Leukemia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2021-10-18
Completion:: 2025-08-01

Conditions

Untreated Chronic Lymphocytic Leukemia

Interventions

DRUG

No Results Yet

NCT04946396 | COMPLETED | NA

64 participants

Effects of Continuous Dexmedetomidine Infusion on Systemic Microvascular Function in Laparoscopic Cholecystecthomy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2022-04-01
Completion:: 2025-05-30

Conditions

Laparoscopic Surgery

Interventions

DRUG

No Results Yet

NCT04944043 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

45 participants

A Study of TQ05105 in Patients With Chronic Graft Versus Host Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2021-06-25
Completion:: 2023-06-30

Conditions

Chronic Graft Versus Host Disease

Interventions

DRUG

No Results Yet

NCT04916652 | RECRUITING

60 participants

A First-ever Research Collaboration to Characterize MRI Measured Neural Flexibility Development in Chinese Toddlers

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-03
Start Date:: 2024-04-06
Completion:: 2026-08-31

Conditions

Growth & Development
Brain

Interventions

RADIATION

No Results Yet

NCT04914299 | WITHDRAWN | NA

0 participants

Prospective Study Evaluating a Novel Mobile App Based Preventive Behavioral Intervention for Perinatal Mood Disorders

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2021-07-01
Completion:: 2022-07-01

Conditions

Perinatal Depression
Perinatal Anxiety

Interventions

BEHAVIORAL

No Results Yet