Clinical Trials Updated in 2025

NCT05950906 | COMPLETED | PHASE1

64 participants

Study to Assess PDM608 in Healthy Adult Subjects

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2023-06-27
Completion:: 2024-03-17

Conditions

Parkinson Disease

Interventions

DRUG

Results Available

NCT05945901 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3

669 participants

A Phase II/III Study of HR070803 in Combination With Oxaliplatin, 5-fluorouracil, Calcium Folinate and Bevacizumab Versus FOLFOX in Combination With Bevacizumab for First-line Treatment of Advanced Colorectal Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2023-08-14
Completion:: 2025-12-01

Conditions

Colorectal Cancer

Interventions

DRUG

No Results Yet

NCT05943457 | RECRUITING | NA

160 participants

Vitamin K2 Supplementation in Adult Episodic Migraine

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2024-03-06
Completion:: 2026-09-30

Conditions

Migraine Headache
Arterial Stiffness
Vitamin K Deficiency

Interventions

DIETARY_SUPPLEMENT
OTHER

No Results Yet

NCT05942040 | COMPLETED | NA

301 participants

Translating Data Science to Palliative Care

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2024-02-15
Completion:: 2024-09-30

Conditions

Alzheimer's Disease and Related Dementias

Interventions

OTHER

Results Available

NCT05940012 | COMPLETED | NA

122 participants

Specific and Shared Mechanisms Associated With Treatment for Chronic Neck Pain

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2024-01-01
Completion:: 2025-04-30

Conditions

Chronic Neck Pain

Interventions

OTHER

No Results Yet

NCT05910398 | RECRUITING | PHASE3

488 participants

Continuous or Intermittent Extension of Adjuvant Pyrotinib for Invasive HER2-positive Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2023-06-01
Completion:: 2030-04-30

Conditions

Breast Cancer Invasive

Interventions

DRUG

No Results Yet

NCT05905822 | COMPLETED

49 participants

DIetary plAnt Extracts, Colonic MicrObes, and Apoe geNetics Interactions stuDy

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-18
Start Date:: 2023-06-19
Completion:: 2025-09-30

Conditions

Alzheimer Disease

No Results Yet

NCT05877586 | COMPLETED | NA

50 participants

CLARE Mobile App for Caregiver Training and Support

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2023-10-09
Completion:: 2024-09-19

Conditions

Caregivers
Technology

Interventions

OTHER

Results Available

NCT05866367 | TERMINATED | PHASE1

2 participants

Measurement of Insulin Levels in Cerebral Spinal Fluid (CSF) of Healthy Adults After a Single Intranasal Dose

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2023-08-16
Completion:: 2024-06-28

Conditions

Healthy

Interventions

DRUG

Results Available

NCT05859100 | COMPLETED | NA

2 participants

Can Protein Intake be Increased Using Whole Foods Post-treatment in Cancer Patients?

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2023-09-01
Completion:: 2025-06-15

Conditions

Cancer
Other Malnutrition

Interventions

OTHER

No Results Yet

NCT05850182 | RECRUITING | NA

30 participants

Lifestyle Intervention in Patients With Metastatic Prostate Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2023-11-27
Completion:: 2026-12-31

Conditions

Prostate Cancer

Interventions

BEHAVIORAL

No Results Yet

NCT05846373 | COMPLETED | PHASE2

58 participants

Effect of Nicotinic Acid as Add on Therapy in Patients Receiving β Blocker for Prophylaxis of Moderate to Severe Migraine

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2022-11-25
Completion:: 2024-01-10

Conditions

Migraine Prophylaxis

Interventions

DRUG
OTHER

No Results Yet

NCT05836545 | COMPLETED | PHASE3

132 participants

Remimazolam Versus Midaszolam for Sedation in Diagnostic Upper Gastrointestinal Endoscopy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2023-04-05
Completion:: 2024-01-06

Conditions

Healthy

Interventions

DRUG

No Results Yet

NCT05831709 | RECRUITING | NA

390 participants

The Influence of Hormone Replacement Therapy and Supervised Exercise Training on Body Composition, Cardiovascular Risk and Insulin Sensitivity in Postmenopausal Women

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2023-05-12
Completion:: 2027-12-31

Conditions

Postmenopause
Menopausal Complaints

Interventions

OTHER
DRUG

No Results Yet

NCT05800275 | RECRUITING | PHASE2

30 participants

Capecitabine, Tucatinib, and Intrathecal Trastuzumab for Breast Cancer Patients With Leptomeningeal Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2023-12-18
Completion:: 2026-12-31

Conditions

Leptomeningeal Metastasis
Leptomeningeal Disease
HER2-positive Metastatic Breast Cancer

Interventions

DRUG

No Results Yet

NCT05792722 | RECRUITING | NA

70 participants

Evaluating Safety and Efficacy of Prostate-sparing Radical Cystectomy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2023-10-25
Completion:: 2028-07-31

Conditions

Bladder Cancer

Interventions

PROCEDURE

No Results Yet

NCT05782270 | RECRUITING | PHASE4

202 participants

Antithrombotic Therapy After Coronary Artery Bypass Grafting Combined With Coronary Endarterectomy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2023-04-11
Completion:: 2025-09-25

Conditions

Anticoagulation
Coronary Endarterectomy

Interventions

DRUG
OTHER

No Results Yet

NCT05781308 | ACTIVE_NOT_RECRUITING | PHASE2

156 participants

Combination of Paclitaxel-bevacizumab ± Atezolizumab in Patients With Advanced NSCLC Progressing After Immunotherapy & Chemotherapy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2023-04-26
Completion:: 2025-06-02

Conditions

Non Small Cell Lung Cancer

Interventions

DRUG

No Results Yet

NCT05778474 | COMPLETED

25 participants

Mechanical Determinants of Upper Limbs Oscillation During Gait

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-18
Start Date:: 2020-05-27
Completion:: 2024-12-31

Conditions

Multiple Sclerosis
Poststroke/CVA Hemiparesis
Parkinson Disease
Cerebral Palsy
Amputation

Interventions

OTHER

No Results Yet

NCT05774977 | COMPLETED | NA

27 participants

Broadband Sound and Sleep

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2023-10-31
Completion:: 2024-06-17

Conditions

Noise Exposure

Interventions

OTHER

Results Available

NCT05773859 | RECRUITING | PHASE1/PHASE2

10 participants

NEOadjuvant Dendritic Cell Vaccination for Ovarian Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2023-03-17
Completion:: 2026-03-31

Conditions

Epithelial Ovarian Cancer
Ovarian Carcinoma

Interventions

BIOLOGICAL

No Results Yet

NCT05769972 | COMPLETED | NA

64 participants

Efficacy of Cognitive Rehabilitation Using Virtual Reality and Computer-based Cognitive Stimulation on Cognitive Impairment Associated to Movement Disorders

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2021-10-13
Completion:: 2022-09-21

Conditions

Parkinson Disease
Huntington Disease

Interventions

DEVICE
BEHAVIORAL

No Results Yet

NCT05762172 | COMPLETED | NA

8 participants

Dynamic F-DOPA PET for Differential Diagnosis Between Recurrence and Radionecrosis of Brain Metastasis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2022-02-01
Completion:: 2024-11-11

Conditions

Brain Metastases
Radiation Necrosis

Interventions

OTHER

No Results Yet

NCT05759286 | COMPLETED | NA

108 participants

A Blend of Lavender-neroli Oils Aromatherapy and Music for Managing Anxiety in a Pediatric Patient

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2021-09-15
Completion:: 2022-03-20

Conditions

Dental Anxiety

Interventions

BEHAVIORAL

No Results Yet

NCT05758285 | COMPLETED

6671 participants

Using Responsible Artificial Intelligence (AI) to Predict Online Therapy Outcome and Engagement

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-18
Start Date:: 2023-03-01
Completion:: 2024-12-06

Conditions

Mental Health Care
Mental Disorders

Interventions

OTHER

No Results Yet

NCT05751343 | RECRUITING | PHASE2

55 participants

Atezolizumab and Bevacizumab Plus TACE-HAIC for Unresectable Advanced HCC: a Phase 2 Clinical Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2023-03-09
Completion:: 2024-08-28

Conditions

Hepatocellular Carcinoma

Interventions

DRUG

No Results Yet

NCT05748145 | RECRUITING | PHASE2

40 participants

Metronidazole as Preoperative Therapy in CRC / FusoMetro-001

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2023-09-11
Completion:: 2026-12-31

Conditions

Colorectal Cancer

Interventions

DRUG

No Results Yet

NCT05732649 | COMPLETED | NA

65 participants

Improving Visual Perception and Visuo-motor Learning With Neurofeedback of Brain Network Interaction.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2023-05-01
Completion:: 2025-05-31

Conditions

Healthy

Interventions

BEHAVIORAL

No Results Yet

NCT05728359 | RECRUITING

300 participants

Genomic Determinants of Outcome in Cardiogenic Shock

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-18
Start Date:: 2022-08-08
Completion:: 2026-11-01

Conditions

Cardiogenic Shock

Interventions

OTHER

No Results Yet

NCT05714514 | ACTIVE_NOT_RECRUITING

64 participants

Survival and Dialysis Independency in Highly Sensitized Patients After Desensitization With Imlifidase and Tx of Kidneys

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-18
Start Date:: 2023-04-21
Completion:: 2027-12-31

Conditions

Kidney Transplantation in Highly Sensitized Patients

Interventions

DRUG
OTHER

No Results Yet

NCT05710224 | COMPLETED | PHASE2

1364 participants

Clinical Bridging Study Between V181 (Dengue Quadrivalent Vaccine rDENVΔ30 [Live, Attenuated]) to Butantan Dengue Vaccine (Butantan - DV) in Healthy Adults 18 to 50 Years of Age in Brazil (V181 - 002)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2023-02-15
Completion:: 2024-01-22

Conditions

Dengue

Interventions

BIOLOGICAL

Results Available

NCT05709912 | ACTIVE_NOT_RECRUITING | NA

120 participants

Mobile CARE-App to Promote Coping for Caregivers of Patients Receiving Stem Cell Transplant

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2023-07-01
Completion:: 2024-12-01

Conditions

Bone Marrow Transplant Complications
Hematologic Malignancy

Interventions

BEHAVIORAL

No Results Yet

NCT05706701 | COMPLETED | NA

36 participants

Nicotine Flux, a Potentially Powerful Tool for Regulating Nicotine Delivery From Electronic Cigarettes

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2023-02-01
Completion:: 2024-05-17

Conditions

Nicotine Vaping

Interventions

OTHER

Results Available

NCT05690945 | ACTIVE_NOT_RECRUITING | PHASE3

606 participants

A Study of QL1706 in Combination With Chemotherapy in PD-L1-Negative Non-small Cell Lung Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2023-02-15
Completion:: 2029-06-30

Conditions

Lung Cancer

Interventions

DRUG

No Results Yet

NCT05672615 | RECRUITING

42 participants

Mood Alterations in the Patients With Non-Muscle Invasive Bladder Cancer Treated With BCG

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-18
Start Date:: 2023-03-21
Completion:: 2027-03-31

Conditions

Non-Muscle Invasive Bladder Cancer

Interventions

OTHER

No Results Yet

NCT05638204 | RECRUITING | NA

390 participants

Effectiveness of the Suicidal Crisis Intervention (SCI)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2023-07-11
Completion:: 2025-12-31

Conditions

Suicide
Suicidal Ideation
Suicide, Attempted

Interventions

BEHAVIORAL

No Results Yet

NCT05630755 | ACTIVE_NOT_RECRUITING | PHASE3

514 participants

A Switch to Doravirine/Islatravir (DOR/ISL) in Participants With Human Immunodeficiency Virus Type 1 (HIV-1) Who Are Virologically Suppressed on Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIC/FTC/TAF) (MK-8591A-052)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2023-02-17
Completion:: 2024-10-25

Conditions

HIV-1 Infection

Interventions

DRUG

Results Available

NCT05625282 | RECRUITING | NA

70 participants

Plantar Plate Repair for Treatment of Floating Toe: Must we Associate it to Weil Osteotomy?

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2022-11-18
Completion:: 2026-06-30

Conditions

Floating Toe

Interventions

PROCEDURE

No Results Yet

NCT05567068 | COMPLETED | PHASE2

54 participants

Atorvastatin Efficacy and Safety in Patients With Ulcerative Colitis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2023-02-01
Completion:: 2025-06-01

Conditions

Inflammatory Bowel Diseases

Interventions

DRUG

No Results Yet

NCT05561829 | COMPLETED | NA

489 participants

Determination of Optimal Sleep Treatment Elements - MOST

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-18
Start Date:: 2022-09-08
Completion:: 2024-05-18

Conditions

Insomnia Chronic

Interventions

BEHAVIORAL

No Results Yet