Clinical Trials Updated in 2025

NCT04992273 | TERMINATED | PHASE2

7 participants

COVID-19 Administration of Single-Dose Subcutaneous Anti- Spike(s) SARS-CoV-2 Monoclonal Antibodies Casirivimab and Imdevimab in High-Risk Pediatric Participants Under 12 Years of Age

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2021-09-13
Completion:: 2022-06-01

Conditions

COVID-19

Interventions

DRUG

Results Available

NCT04991025 | RECRUITING | PHASE2

60 participants

Adding Certolizumab to Chemotherapy + Nivolumab in People Who Have Lung Cancer That Can Be Treated With Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2022-10-19
Completion:: 2026-10-31

Conditions

Lung Cancer
Lung Cancer Stage II
Lung Cancer Stage III

Interventions

DRUG

No Results Yet

NCT04939233 | COMPLETED | NA

3 participants

Robotic Hand Orthosis Providing Grasp Assistance for Patients With Brachial Plexus Injuries

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2021-07-01
Completion:: 2022-05-20

Conditions

Brachial Plexus Injury

Interventions

DEVICE

Results Available

NCT04852978 | COMPLETED | PHASE2

295 participants

COVID-19 Study to Assess Immunogenicity, Safety, and Tolerability of Moderna mRNA-1273 Vaccine Administered With Casirivimab+Imdevimab in Healthy Adult Volunteers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2021-04-29
Completion:: 2022-11-21

Conditions

Healthy
Chronic Stable Illness

Interventions

DRUG
BIOLOGICAL

Results Available

NCT04839783 | TERMINATED

234 participants

Single Position Spine Surgery Registry

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-17
Start Date:: 2020-07-07
Completion:: 2025-07-07

Conditions

Spine Fusion
Spinal Stenosis
Degenerative Disc Disease

No Results Yet

NCT04838405 | COMPLETED | PHASE1

129 participants

A Study of CT-388 in Otherwise Healthy Overweight and Obese Adults and Patients With Type 2 Diabetes Mellitus

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2021-04-29
Completion:: 2024-06-18

Conditions

Diabetes

Interventions

DRUG

No Results Yet

NCT04766138 | COMPLETED | NA

35 participants

Trial to Evaluate Fecobionics in Healthy Subjects and Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2021-01-01
Completion:: 2022-12-09

Conditions

Normal Subjects
Fecal Incontinence

Interventions

DEVICE

No Results Yet

NCT04762277 | COMPLETED | PHASE2

52 participants

A Study to Test Whether Spesolimab Helps People With a Skin Disease Called Hidradenitis Suppurativa

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2021-04-06
Completion:: 2022-01-19

Conditions

Hidradenitis Suppurativa

Interventions

DRUG

Results Available

NCT04677738 | COMPLETED | NA

95 participants

Investigation of the Effects of a Bifidobacterium Breve Strain on Fat Loss in Healthy Adults

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2020-08-20
Completion:: 2024-01-05

Conditions

Obesity
Overweight and Obesity

Interventions

DIETARY_SUPPLEMENT

Results Available

NCT04613921 | RECRUITING

3000 participants

Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-17
Start Date:: 2021-07-08
Completion:: 2026-12-31

Conditions

Liver Diseases
Liver Cirrhosis
Acute-On-Chronic Liver Failure
Liver Transplant; Complications

Interventions

OTHER

No Results Yet

NCT04603586 | COMPLETED | NA

119 participants

Stereotactic Radiotherapy in Locally Advanced Pancreatic Cancer With Different Biological Effective Doses

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2020-11-10
Completion:: 2025-08-15

Conditions

Treatment

Interventions

RADIATION
DRUG

Results Available

NCT04600089 | RECRUITING | PHASE2

30 participants

Ketamine in Patients Undergoing TEVAR Procedures Receiving NCI

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2020-12-08
Completion:: 2027-08-31

Conditions

Descending Aortic Dissection
Postoperative Pain
Thoracoabdominal Aortic Aneurysm

Interventions

DRUG

No Results Yet

NCT04592978 | COMPLETED | NA

206 participants

Personalized Feedback Intervention for Alcohol and Opioid Use Among Adults With Chronic Pain

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2021-07-30
Completion:: 2025-04-30

Conditions

Alcohol Drinking
Pain
Opioid Use
Feedback, Psychological

Interventions

BEHAVIORAL

No Results Yet

NCT04543539 | ACTIVE_NOT_RECRUITING

240 participants

IN.PACT™ AV Access Post-Approval Study (PAS002)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-17
Start Date:: 2020-11-13
Completion:: 2025-06-03

Conditions

Arteriovenous Fistula
Arteriovenous Fistula Stenosis
Arteriovenous Fistula Occlusion
Fistula

Interventions

COMBINATION_PRODUCT

No Results Yet

NCT04511702 | COMPLETED | PHASE4

191 participants

Infusion Duration Study To Assess Tolerability of Pegloticase Administered With a Shorter Infusion Duration in Subjects With Uncontrolled Gout Receiving Methotrexate

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2020-10-02
Completion:: 2024-01-18

Conditions

Chronic Uncontrolled Gout
Gout
Uncontrolled Gout

Interventions

BIOLOGICAL

Results Available

NCT04493424 | TERMINATED | PHASE2

108 participants

A Study to Test Long-term Treatment With Spesolimab in People With Palmoplantar Pustulosis (PPP) Who Took Part in Previous Studies With Spesolimab

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2020-09-04
Completion:: 2023-01-16

Conditions

Palmoplantar Pustulosis

Interventions

DRUG

Results Available

NCT04471909 | RECRUITING | NA

110 participants

NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2020-10-20
Completion:: 2025-10-31

Conditions

Aortic Dissection
Aortic Aneurysm
Intramural Hematoma
Penetrating Aortic Ulcer

Interventions

DEVICE

No Results Yet

NCT04470505 | COMPLETED

16 participants

Optimizing Platelet Isolation (The Cell Study)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-17
Start Date:: 2020-07-06
Completion:: 2021-01-25

Conditions

Healthy

No Results Yet

NCT04446481 | COMPLETED | NA

4 participants

Neurofeedback to Aid Vets' Memory

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2022-02-05
Completion:: 2025-09-30

Conditions

Mild Cognitive Impairment

Interventions

DEVICE

No Results Yet

NCT04399837 | COMPLETED | PHASE2

123 participants

A Study to Test Whether BI 655130 (Spesolimab) Prevents Flare-ups in Patients With Generalized Pustular Psoriasis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2020-06-04
Completion:: 2022-11-23

Conditions

Generalized Pustular Psoriasis

Interventions

DRUG

Results Available

NCT04248803 | COMPLETED | NA

570 participants

Evaluation of Gluma Desensitizer in Post-treatment Sensitivity in Posterior Composite

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2020-02-06
Completion:: 2025-02-20

Conditions

Sensitivity, Tooth

Interventions

OTHER

Results Available

NCT04166071 | ENROLLING_BY_INVITATION | EARLY_PHASE1

60 participants

Opioids and Social Support Enhanced Extinction Effects

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2021-12-13
Completion:: 2026-09-30

Conditions

Fear

Interventions

DRUG

No Results Yet

NCT04094090 | RECRUITING | PHASE2

500 participants

Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking in Eyes With Corneal Ectasia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2019-10-19
Completion:: 2029-10-19

Conditions

Keratoconus
Pellucid Marginal Corneal Degeneration
Corneal Ectasia

Interventions

COMBINATION_PRODUCT

No Results Yet

NCT04049227 | COMPLETED | EARLY_PHASE1

27 participants

Abemaciclib and Letrozole in Treating Patients With Endometrial Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2019-08-12
Completion:: 2023-04-01

Conditions

Endometrial Endometrioid Adenocarcinoma

Interventions

DRUG
PROCEDURE

No Results Yet

NCT03983252 | WITHDRAWN | PHASE1/PHASE2

0 participants

Effect of Alemtuzumab on Microglial Activation Positron Emission Tomography (PET) in Multiple Sclerosis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2021-12-31
Completion:: 2024-05-01

Conditions

Multiple Sclerosis

Interventions

DRUG

No Results Yet

NCT03850379 | COMPLETED | PHASE2

308 participants

Ciprofloxacin Versus Levofloxacin in Stem Cell Transplant

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2018-03-14
Completion:: 2024-08-30

Conditions

Prophylaxis
Stem Cell Transplant Complications

Interventions

DRUG

Results Available

NCT03822832 | COMPLETED | PHASE2

51 participants

A Study in Patients With Atopic Eczema to Test How Effective BI 655130 is and How Well it is Tolerated

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2019-02-12
Completion:: 2020-01-17

Conditions

Dermatitis, Atopic

Interventions

DRUG

Results Available

NCT03690219 | COMPLETED

99 participants

Prevalence of Acute Injuries in Amateur and Elite Mountain Bikers

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-17
Start Date:: 2017-09-11
Completion:: 2017-09-16

Conditions

Acute Injury in Mountain Biking

Interventions

OTHER

Results Available

NCT03683030 | COMPLETED | PHASE3

397 participants

Safety and Effectiveness Evaluation of the Multi-Electrode Radiofrequency Balloon Catheter for the Treatment of Symptomatic Paroxysmal Atrial Fibrillation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2018-10-22
Completion:: 2022-02-18

Conditions

Atrial Fibrillation

Interventions

DEVICE

Results Available

NCT03648541 | COMPLETED | PHASE2

79 participants

BI 655130 Long-term Treatment in Patients With moderate-to Severe Ulcerative Colitis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2018-10-29
Completion:: 2023-05-03

Conditions

Colitis, Ulcerative

Interventions

DRUG

Results Available

NCT03634007 | COMPLETED | PHASE1/PHASE2

15 participants

Gene Therapy for APOE4 Homozygote of Alzheimer's Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2019-11-06
Completion:: 2024-11-07

Conditions

Alzheimer Disease
Early Onset Alzheimer Disease

Interventions

BIOLOGICAL

No Results Yet

NCT03617835 | COMPLETED | PHASE1

48 participants

A Study in Healthy People to Measure the Amount of BI 655130 in the Blood After Injecting Different Doses Into Different Parts of the Body

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2018-08-16
Completion:: 2019-06-03

Conditions

Healthy

Interventions

DRUG

Results Available

NCT03499587 | ACTIVE_NOT_RECRUITING

13 participants

Effects of Maternal Obesity on Offspring Brain Development

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-17
Start Date:: 2018-03-21
Completion:: 2026-06-27

Conditions

Healthy

No Results Yet

NCT03386396 | ACTIVE_NOT_RECRUITING | NA

151 participants

Brain Fuel - Morning Nutrition and Cognitive Function

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2017-11-28
Completion:: 2024-01-06

Conditions

Obese
Healthy

Interventions

DIETARY_SUPPLEMENT

No Results Yet

NCT03374319 | COMPLETED | NA

50 participants

Somatotopic Configuration of Distal Residual Limb Tissues in Lower Extremity Amputations

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2017-09-15
Completion:: 2024-09-30

Conditions

Amputation

Interventions

PROCEDURE

No Results Yet

NCT03313999 | TERMINATED | NA

7 participants

Measuring Skin Elasticity in Lymphedema Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2018-02-18
Completion:: 2025-06-02

Conditions

Diagnoses Disease
Lymphedema

Interventions

DEVICE

No Results Yet

NCT03266939 | WITHDRAWN | PHASE1

0 participants

Rebalancing the Serotonergic System in Cocaine Dependence

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2018-10-04
Completion:: 2018-10-04

Conditions

Cocaine Dependence

Interventions

DRUG

No Results Yet

NCT02786966 | COMPLETED | NA

3646 participants

A Pragmatic Evaluation of the Canadian C-Spine Rule by Paramedics

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2017-03-01
Completion:: 2018-04-30

Conditions

Neck Injuries

Interventions

OTHER

Results Available

NCT02680795 | COMPLETED | PHASE1

17 participants

Establish the PK of Belinostat in Patients With Wild-type, Heterozygous, and Homozygous UGT1A1*28 Genotypes

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2016-04-27
Completion:: 2020-07-21

Conditions

Solid Tumors
Hematological Malignancies

Interventions

DRUG

No Results Yet

NCT02676960 | COMPLETED

23 participants

Feasibility Study: MRI on 6 Months, 1 Year, and 2 Years Old Children Without Sedation

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-17
Start Date:: 2016-01-31
Completion:: 2022-08-01

Conditions

Healthy

Interventions

OTHER

No Results Yet