Clinical Trials Updated in 2025

NCT04852978 | COMPLETED | PHASE2

295 participants

COVID-19 Study to Assess Immunogenicity, Safety, and Tolerability of Moderna mRNA-1273 Vaccine Administered With Casirivimab+Imdevimab in Healthy Adult Volunteers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2021-04-29
Completion:: 2022-11-21

Conditions

Healthy
Chronic Stable Illness

Interventions

DRUG
BIOLOGICAL

Results Available

NCT04839783 | TERMINATED

234 participants

Single Position Spine Surgery Registry

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-17
Start Date:: 2020-07-07
Completion:: 2025-07-07

Conditions

Spine Fusion
Spinal Stenosis
Degenerative Disc Disease

No Results Yet

NCT04838405 | COMPLETED | PHASE1

129 participants

A Study of CT-388 in Otherwise Healthy Overweight and Obese Adults and Patients With Type 2 Diabetes Mellitus

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2021-04-29
Completion:: 2024-06-18

Conditions

Diabetes

Interventions

DRUG

No Results Yet

NCT04766138 | COMPLETED | NA

35 participants

Trial to Evaluate Fecobionics in Healthy Subjects and Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2021-01-01
Completion:: 2022-12-09

Conditions

Normal Subjects
Fecal Incontinence

Interventions

DEVICE

No Results Yet

NCT04762277 | COMPLETED | PHASE2

52 participants

A Study to Test Whether Spesolimab Helps People With a Skin Disease Called Hidradenitis Suppurativa

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2021-04-06
Completion:: 2022-01-19

Conditions

Hidradenitis Suppurativa

Interventions

DRUG

Results Available

NCT04677738 | COMPLETED | NA

95 participants

Investigation of the Effects of a Bifidobacterium Breve Strain on Fat Loss in Healthy Adults

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2020-08-20
Completion:: 2024-01-05

Conditions

Obesity
Overweight and Obesity

Interventions

DIETARY_SUPPLEMENT

Results Available

NCT04613921 | RECRUITING

3000 participants

Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-17
Start Date:: 2021-07-08
Completion:: 2026-12-31

Conditions

Liver Diseases
Liver Cirrhosis
Acute-On-Chronic Liver Failure
Liver Transplant; Complications

Interventions

OTHER

No Results Yet

NCT04603586 | COMPLETED | NA

119 participants

Stereotactic Radiotherapy in Locally Advanced Pancreatic Cancer With Different Biological Effective Doses

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2020-11-10
Completion:: 2025-08-15

Conditions

Treatment

Interventions

RADIATION
DRUG

Results Available

NCT04600089 | RECRUITING | PHASE2

30 participants

Ketamine in Patients Undergoing TEVAR Procedures Receiving NCI

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2020-12-08
Completion:: 2027-08-31

Conditions

Descending Aortic Dissection
Postoperative Pain
Thoracoabdominal Aortic Aneurysm

Interventions

DRUG

No Results Yet

NCT04543539 | ACTIVE_NOT_RECRUITING

240 participants

IN.PACT™ AV Access Post-Approval Study (PAS002)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-17
Start Date:: 2020-11-13
Completion:: 2025-06-03

Conditions

Arteriovenous Fistula
Arteriovenous Fistula Stenosis
Arteriovenous Fistula Occlusion
Fistula

Interventions

COMBINATION_PRODUCT

No Results Yet

NCT04511702 | COMPLETED | PHASE4

191 participants

Infusion Duration Study To Assess Tolerability of Pegloticase Administered With a Shorter Infusion Duration in Subjects With Uncontrolled Gout Receiving Methotrexate

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2020-10-02
Completion:: 2024-01-18

Conditions

Chronic Uncontrolled Gout
Gout
Uncontrolled Gout

Interventions

BIOLOGICAL

Results Available

NCT04493424 | TERMINATED | PHASE2

108 participants

A Study to Test Long-term Treatment With Spesolimab in People With Palmoplantar Pustulosis (PPP) Who Took Part in Previous Studies With Spesolimab

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2020-09-04
Completion:: 2023-01-16

Conditions

Palmoplantar Pustulosis

Interventions

DRUG

Results Available

NCT04471909 | RECRUITING | NA

110 participants

NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2020-10-20
Completion:: 2025-10-31

Conditions

Aortic Dissection
Aortic Aneurysm
Intramural Hematoma
Penetrating Aortic Ulcer

Interventions

DEVICE

No Results Yet

NCT04470505 | COMPLETED

16 participants

Optimizing Platelet Isolation (The Cell Study)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-17
Start Date:: 2020-07-06
Completion:: 2021-01-25

Conditions

Healthy

No Results Yet

NCT04446481 | COMPLETED | NA

4 participants

Neurofeedback to Aid Vets' Memory

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2022-02-05
Completion:: 2025-09-30

Conditions

Mild Cognitive Impairment

Interventions

DEVICE

No Results Yet

NCT04399837 | COMPLETED | PHASE2

123 participants

A Study to Test Whether BI 655130 (Spesolimab) Prevents Flare-ups in Patients With Generalized Pustular Psoriasis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2020-06-04
Completion:: 2022-11-23

Conditions

Generalized Pustular Psoriasis

Interventions

DRUG

Results Available

NCT04248803 | COMPLETED | NA

570 participants

Evaluation of Gluma Desensitizer in Post-treatment Sensitivity in Posterior Composite

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2020-02-06
Completion:: 2025-02-20

Conditions

Sensitivity, Tooth

Interventions

OTHER

Results Available

NCT04166071 | ENROLLING_BY_INVITATION | EARLY_PHASE1

60 participants

Opioids and Social Support Enhanced Extinction Effects

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2021-12-13
Completion:: 2026-09-30

Conditions

Fear

Interventions

DRUG

No Results Yet

NCT04094090 | RECRUITING | PHASE2

500 participants

Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking in Eyes With Corneal Ectasia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2019-10-19
Completion:: 2029-10-19

Conditions

Keratoconus
Pellucid Marginal Corneal Degeneration
Corneal Ectasia

Interventions

COMBINATION_PRODUCT

No Results Yet

NCT04049227 | COMPLETED | EARLY_PHASE1

27 participants

Abemaciclib and Letrozole in Treating Patients With Endometrial Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2019-08-12
Completion:: 2023-04-01

Conditions

Endometrial Endometrioid Adenocarcinoma

Interventions

DRUG
PROCEDURE

No Results Yet

NCT03983252 | WITHDRAWN | PHASE1/PHASE2

0 participants

Effect of Alemtuzumab on Microglial Activation Positron Emission Tomography (PET) in Multiple Sclerosis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2021-12-31
Completion:: 2024-05-01

Conditions

Multiple Sclerosis

Interventions

DRUG

No Results Yet

NCT03850379 | COMPLETED | PHASE2

308 participants

Ciprofloxacin Versus Levofloxacin in Stem Cell Transplant

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2018-03-14
Completion:: 2024-08-30

Conditions

Prophylaxis
Stem Cell Transplant Complications

Interventions

DRUG

Results Available

NCT03822832 | COMPLETED | PHASE2

51 participants

A Study in Patients With Atopic Eczema to Test How Effective BI 655130 is and How Well it is Tolerated

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2019-02-12
Completion:: 2020-01-17

Conditions

Dermatitis, Atopic

Interventions

DRUG

Results Available

NCT03690219 | COMPLETED

99 participants

Prevalence of Acute Injuries in Amateur and Elite Mountain Bikers

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-17
Start Date:: 2017-09-11
Completion:: 2017-09-16

Conditions

Acute Injury in Mountain Biking

Interventions

OTHER

Results Available

NCT03683030 | COMPLETED | PHASE3

397 participants

Safety and Effectiveness Evaluation of the Multi-Electrode Radiofrequency Balloon Catheter for the Treatment of Symptomatic Paroxysmal Atrial Fibrillation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2018-10-22
Completion:: 2022-02-18

Conditions

Atrial Fibrillation

Interventions

DEVICE

Results Available

NCT03648541 | COMPLETED | PHASE2

79 participants

BI 655130 Long-term Treatment in Patients With moderate-to Severe Ulcerative Colitis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2018-10-29
Completion:: 2023-05-03

Conditions

Colitis, Ulcerative

Interventions

DRUG

Results Available

NCT03634007 | COMPLETED | PHASE1/PHASE2

15 participants

Gene Therapy for APOE4 Homozygote of Alzheimer's Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2019-11-06
Completion:: 2024-11-07

Conditions

Alzheimer Disease
Early Onset Alzheimer Disease

Interventions

BIOLOGICAL

No Results Yet

NCT03617835 | COMPLETED | PHASE1

48 participants

A Study in Healthy People to Measure the Amount of BI 655130 in the Blood After Injecting Different Doses Into Different Parts of the Body

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2018-08-16
Completion:: 2019-06-03

Conditions

Healthy

Interventions

DRUG

Results Available

NCT03499587 | ACTIVE_NOT_RECRUITING

13 participants

Effects of Maternal Obesity on Offspring Brain Development

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-17
Start Date:: 2018-03-21
Completion:: 2026-06-27

Conditions

Healthy

No Results Yet

NCT03386396 | ACTIVE_NOT_RECRUITING | NA

151 participants

Brain Fuel - Morning Nutrition and Cognitive Function

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2017-11-28
Completion:: 2024-01-06

Conditions

Obese
Healthy

Interventions

DIETARY_SUPPLEMENT

No Results Yet

NCT03374319 | COMPLETED | NA

50 participants

Somatotopic Configuration of Distal Residual Limb Tissues in Lower Extremity Amputations

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2017-09-15
Completion:: 2024-09-30

Conditions

Amputation

Interventions

PROCEDURE

No Results Yet

NCT03313999 | TERMINATED | NA

7 participants

Measuring Skin Elasticity in Lymphedema Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2018-02-18
Completion:: 2025-06-02

Conditions

Diagnoses Disease
Lymphedema

Interventions

DEVICE

No Results Yet

NCT03266939 | WITHDRAWN | PHASE1

0 participants

Rebalancing the Serotonergic System in Cocaine Dependence

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2018-10-04
Completion:: 2018-10-04

Conditions

Cocaine Dependence

Interventions

DRUG

No Results Yet

NCT02786966 | COMPLETED | NA

3646 participants

A Pragmatic Evaluation of the Canadian C-Spine Rule by Paramedics

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2017-03-01
Completion:: 2018-04-30

Conditions

Neck Injuries

Interventions

OTHER

Results Available

NCT02680795 | COMPLETED | PHASE1

17 participants

Establish the PK of Belinostat in Patients With Wild-type, Heterozygous, and Homozygous UGT1A1*28 Genotypes

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2016-04-27
Completion:: 2020-07-21

Conditions

Solid Tumors
Hematological Malignancies

Interventions

DRUG

No Results Yet

NCT02676960 | COMPLETED

23 participants

Feasibility Study: MRI on 6 Months, 1 Year, and 2 Years Old Children Without Sedation

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-17
Start Date:: 2016-01-31
Completion:: 2022-08-01

Conditions

Healthy

Interventions

OTHER

No Results Yet

NCT02611427 | ACTIVE_NOT_RECRUITING | NA

260 participants

Increasing Long-Term Physical Activity After Lumbar Spine Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2015-11-11
Completion:: 2026-06-30

Conditions

Lumbar Spine Degenerative Changes

Interventions

BEHAVIORAL

No Results Yet

NCT02506283 | COMPLETED | NA

22 participants

The Effect of Thermotherapy on Recovery and Performance

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2015-05-31
Completion:: 2018-11-30

Conditions

Healthy

Interventions

DEVICE

Results Available

NCT02159989 | COMPLETED | PHASE1

83 participants

Sapanisertib and Ziv-Aflibercept in Treating Patients With Recurrent Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-17
Start Date:: 2014-06-18
Completion:: 2021-06-29

Conditions

Advanced Malignant Solid Neoplasm
Fibrolamellar Carcinoma
Metastatic Malignant Solid Neoplasm
Ovarian Carcinoma
Pancreatic Neuroendocrine Tumor
Recurrent Malignant Solid Neoplasm
Refractory Malignant Solid Neoplasm
Unresectable Solid Neoplasm

Interventions

DRUG
BIOLOGICAL

Results Available

NCT01822067 | ACTIVE_NOT_RECRUITING

100 participants

Effects of Maternal Body Composition on Offspring Brain Structure and Function

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-17
Start Date:: 2012-08-31
Completion:: 2026-06-30

Conditions

Brain Function

No Results Yet