Clinical Trials Updated in 2025

NCT06173115 | RECRUITING | NA

876 participants

Comparison of a Single Versus Double Perclose Technique for TAVR

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2023-10-20
Completion:: 2026-04-30

Conditions

Severe Aortic Stenosis

Interventions

DEVICE

No Results Yet

NCT06149104 | COMPLETED | PHASE3

8 participants

A Safety Study of Sacubitril/Valsartan in Japanese Pediatric Patients With Heart Failure Due to Systemic Left Ventricle Systolic Dysfunction Who Have Completed CLCZ696B2319E1 Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2023-12-04
Completion:: 2024-08-14

Conditions

Heart Failure

Interventions

DRUG

Results Available

NCT06143891 | ACTIVE_NOT_RECRUITING | PHASE3

260 participants

A Study to Test an Oral Medicine, Belumosudil, in Combination With Corticosteroids in Participants at Least 12 Years of Age With Newly Diagnosed Chronic Graft Versus Host Disease.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2024-01-23
Completion:: 2028-09-29

Conditions

Chronic Graft Versus Host Disease

Interventions

DRUG

No Results Yet

NCT06104319 | COMPLETED | PHASE2

61 participants

Dose Exploration Study of GSK4532990 in. Participants With NASH or Suspected NASH

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2024-01-22
Completion:: 2025-09-23

Conditions

Non-alcoholic Fatty Liver Disease

Interventions

DRUG

No Results Yet

NCT06042608 | COMPLETED | NA

12 participants

Evaluating Intercostobrachial Nerve Block's Effect on Pain Control After Shoulder Replacement

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2024-09-10
Completion:: 2024-12-13

Conditions

Postoperative Pain, Acute
Shoulder Pain

Interventions

PROCEDURE

No Results Yet

NCT06040918 | COMPLETED | PHASE1

10 participants

Single Center Study Of N-803 Stimulation On Expansion, Enrichment, Proliferation Of Natural Killer Cells Collected By Apheresis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2023-10-04
Completion:: 2024-09-03

Conditions

Healthy Subjects

Interventions

DRUG

No Results Yet

NCT06039566 | RECRUITING | PHASE3

240 participants

NAC vs Placebo on Opioid Use for Hysterectomy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2023-11-30
Completion:: 2026-11-25

Conditions

Hysterectomy

Interventions

DRUG

No Results Yet

NCT06038929 | RECRUITING | NA

16 participants

Effect of Vagal Nerve Stimulation on Gastric Motor Functions

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2025-09-01
Completion:: 2027-07-31

Conditions

Depression
Epilepsy

Interventions

DEVICE

No Results Yet

NCT06006637 | RECRUITING | NA

80 participants

Integrated Platform for Measuring and Reducing Symptoms of Autism Spectrum Disorder

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2023-10-17
Completion:: 2026-08-15

Conditions

Autism Spectrum Disorder

Interventions

DEVICE

No Results Yet

NCT05972616 | COMPLETED

53 participants

Natural Matrix Protein™ (NMP™) in Interbody Lumbar Fusion

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-14
Start Date:: 2023-08-01
Completion:: 2024-02-21

Conditions

Degenerative Disc Disease

Interventions

BIOLOGICAL

No Results Yet

NCT05899673 | ACTIVE_NOT_RECRUITING | PHASE3

31 participants

An Extension Study to Learn About the Long-Term Safety of Fazirsiran and if Fazirsiran Can Help People With Alpha-1 Antitrypsin Liver Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2023-08-08
Completion:: 2033-05-02

Conditions

Alpha1-Antitrypsin Deficiency

Interventions

DRUG

No Results Yet

NCT05888623 | COMPLETED

334200 participants

Computer Assisted Detection of Neoplasia During Colonoscopy Evaluation

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-14
Start Date:: 2022-10-01
Completion:: 2023-06-30

Conditions

Colorectal Neoplasms

Interventions

DEVICE

No Results Yet

NCT05887934 | ENROLLING_BY_INVITATION

500 participants

Bone-Lead Level Associations With Brain and Mental Health

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-14
Start Date:: 2023-08-17
Completion:: 2027-05-01

Conditions

Lead Exposure

Interventions

DEVICE

No Results Yet

NCT05845021 | RECRUITING | NA

2000 participants

Surgeon-Initiated Bone Health Referral Pathway in Patients Undergoing Lower Extremity Arthroplasty

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2023-09-27
Completion:: 2027-10-31

Conditions

Osteoporosis
Arthroplasty Complications
Fragility Fracture

Interventions

COMBINATION_PRODUCT

No Results Yet

NCT05784922 | RECRUITING

2000 participants

Health Opportunities and Promoters of Equitable Screening for Lung Cancer

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-14
Start Date:: 2023-02-03
Completion:: 2028-01-31

Conditions

Lung Cancer
Smoking Behaviors
Diagnosis

Interventions

OTHER

No Results Yet

NCT05772884 | COMPLETED | NA

6 participants

Healthy Aging Through Movement

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2022-05-11
Completion:: 2025-09-05

Conditions

Opioid Use Disorder

Interventions

OTHER

No Results Yet

NCT05732402 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

72 participants

An Open-label Study of Povetacicept in Autoantibody-Associated Glomerular Diseases

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2023-03-15
Completion:: 2028-03-02

Conditions

Lupus Nephritis
Immunoglobulin A Nephropathy
Membranous Nephropathy
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis

Interventions

DRUG

No Results Yet

NCT05684978 | TERMINATED | PHASE4

1 participants

Efficacy and Safety of Perampanel in the Treatment of Refractory Status Epilepticus

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2025-10-10
Completion:: 2025-10-10

Conditions

Refractory Status Epilepticus

Interventions

DRUG

No Results Yet

NCT05681845 | COMPLETED | PHASE1

205 participants

A Study to Compare the Blood Levels of Mim8 in Healthy Men When Administered With the DV3407-C1 Pen Injector or a Syringe and Cartridge

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2023-01-02
Completion:: 2023-10-13

Conditions

Haemophilia A

Interventions

DRUG

No Results Yet

NCT05675722 | RECRUITING | PHASE1

10 participants

Implantation Of Vaginal Construct For Patients With Vaginal Aplasia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2023-06-01
Completion:: 2029-12-31

Conditions

Congenital Mullerian Duct Anomaly

Interventions

BIOLOGICAL

No Results Yet

NCT05643482 | COMPLETED | NA

12 participants

Hyperbaric Oxygen Therapy for Post-Concussion Syndrome

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2023-03-01
Completion:: 2025-05-12

Conditions

Post-Concussion Syndrome

Interventions

DEVICE
OTHER

No Results Yet

NCT05642780 | ACTIVE_NOT_RECRUITING | PHASE2

240 participants

SKB264 in Combination With Pembrolizumab in Subjects With Selected Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2023-01-17
Completion:: 2027-11-30

Conditions

Solid Tumor

Interventions

DRUG

No Results Yet

NCT05640765 | COMPLETED | NA

55 participants

BeWell360-CG Care Model: Health and Wellness Coaching to Support Caregivers of Patients Living With Advanced Lung Cancers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2021-02-03
Completion:: 2022-04-11

Conditions

Advanced Lung Carcinoma
Stage III Lung Cancer AJCC v8
Stage IV Lung Cancer AJCC v8

Interventions

OTHER

No Results Yet

NCT05620108 | COMPLETED | NA

170 participants

Intubating Conditions of Neuromuscular Blockade

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2022-11-28
Completion:: 2024-11-06

Conditions

Endotracheal Intubation

Interventions

PROCEDURE

Results Available

NCT05602623 | COMPLETED | NA

31 participants

Characterizing the Intraocular Scattering at Different Wavelengths

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2023-05-25
Completion:: 2024-06-12

Conditions

Vision, Ocular

Interventions

DEVICE

No Results Yet

NCT05581511 | ACTIVE_NOT_RECRUITING

500 participants

Natural History Study of Cutaneous Neurofibromas in People With NF1

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-14
Start Date:: 2021-06-28
Completion:: 2028-12-31

Conditions

Neurofibromatosis Type 1
Neurofibromatosis 1
Neurofibromatosis (Nonmalignant)
Cutaneous Neurofibroma

Interventions

OTHER

No Results Yet

NCT05561842 | RECRUITING

900 participants

Tablet-based Mobile Health Ultrasound for Point-of-care Breast Cancer Diagnosis in Nigeria (Mobile Health: Technology and Outcomes in Low and Middle-Income Countries)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-14
Start Date:: 2022-09-21
Completion:: 2026-09-21

Conditions

Breast Cancer
Breast Cancer Female

Interventions

PROCEDURE

No Results Yet

NCT05555745 | COMPLETED | NA

101 participants

Audio-based Mental Health Intervention Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2023-02-15
Completion:: 2024-09-10

Conditions

Depressive Symptoms

Interventions

DEVICE

No Results Yet

NCT05530772 | COMPLETED | NA

50 participants

Immediate vs. On-demand Endoscopic Necrosectomy in Infected Walled-off Pancreatic Necrosis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2022-09-12
Completion:: 2025-06-01

Conditions

Pancreatitis, Acute Necrotizing

Interventions

DEVICE

No Results Yet

NCT05519683 | RECRUITING | PHASE2/PHASE3

160 participants

Home Transcutaneous Electrical Acustimulation (TEA)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2022-11-02
Completion:: 2026-09-30

Conditions

Irritable Bowel Syndrome With Constipation

Interventions

DEVICE
DRUG

No Results Yet

NCT05516524 | COMPLETED | NA

62 participants

HSAT for OSA Management in Children

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2022-12-01
Completion:: 2025-09-10

Conditions

Sleep Apnea, Obstructive
Sleep Disorder
Sleep Apnea Syndromes
Sleep Disturbance

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT05486728 | COMPLETED | PHASE2

85 participants

Phase II Study of SHJ002 Sterile Ophthalmic Solution Compared With Vehicle in Participants With Dry Eye Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2023-02-08
Completion:: 2023-12-07

Conditions

Dry Eye Disease

Interventions

DRUG

Results Available

NCT05483023 | WITHDRAWN | PHASE2

0 participants

18-fluorofuranylnorprogesterone (FFNP) PET/MRI as a Potential Biomarker of Response to Progesterone Therapy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2024-02-15
Completion:: 2026-06-28

Conditions

Complex Atypical Hyperplasia
Endometrial Cancer

Interventions

DRUG

No Results Yet

NCT05479734 | COMPLETED | NA

24 participants

Promoting Resilience and Lowering Risk in Early Childhood

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2022-11-07
Completion:: 2023-06-12

Conditions

Child Abuse
Child Neglect
Parenting
Child Development

Interventions

BEHAVIORAL

Results Available

NCT05452122 | RECRUITING | NA

150 participants

Decoding and Selective Modulation of Human Memory During Awake/Sleep Cycles

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2022-07-13
Completion:: 2026-08-31

Conditions

Memory, Delayed

Interventions

OTHER

No Results Yet

NCT05424406 | RECRUITING | NA

150 participants

Role of Sleep Reactivity in Shift Work Disorder

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2023-01-01
Completion:: 2027-06-30

Conditions

Shift-work Disorder

Interventions

BEHAVIORAL

No Results Yet

NCT05384587 | ACTIVE_NOT_RECRUITING | PHASE2

34 participants

Asciminib Monotherapy, With Dose Escalation, for 2nd and 1st Line Chronic Myelogenous Leukemia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2022-11-11
Completion:: 2025-08-13

Conditions

Chronic Myelogenous Leukemia - Chronic Phase

Interventions

DRUG

No Results Yet

NCT05382442 | ACTIVE_NOT_RECRUITING | PHASE2

254 participants

A Study of AK112 With or Without AK117 in Metastatic Colorectal Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2022-06-27
Completion:: 2026-05-15

Conditions

Metastatic Colorectal Cancer

Interventions

DRUG

No Results Yet

NCT05380921 | ENROLLING_BY_INVITATION | NA

700 participants

Testing a Novel Dry Electrode Headset for Electroencephalography Telehealth

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-14
Start Date:: 2022-10-01
Completion:: 2026-09-25

Conditions

Epilepsy

Interventions

DEVICE

No Results Yet

NCT05377320 | NOT_YET_RECRUITING

60 participants

PAtient Similarity for Decision-Making in Prevention of Cardiovascular Toxicity (PACT): A Feasibility Study

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-14
Start Date:: 2026-12-31
Completion:: 2027-12-31

Conditions

Heart Failure
Coronary Artery Disease
Peripheral Artery Disease
Ischemia
Hypertension
Diabetes Mellitus
Cardiomyopathies
Cardiotoxicity

Interventions

OTHER

No Results Yet