Clinical Trials Updated in 2025

NCT05852457 | RECRUITING

250 participants

Evaluation of the Clinical Utility of Endoscopic Closure Using a Dual Action Tissue (DAT) Clip

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-08
Start Date:: 2022-08-31
Completion:: 2027-08-31

Conditions

GI Bleeding
Perforation Colon
Perforation Bowel
Perforation Duodenal
Perforated Bowel
Fistula

Interventions

DEVICE

No Results Yet

NCT05640947 | RECRUITING | NA

20 participants

Endoscopic Ultrasound-guided Large Diameter Lumen-apposing Metal Stent Gastro-gastrostomy for Bypass Reversal in Patients With Roux-en-y Gastric Bypass

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2023-01-30
Completion:: 2027-10-31

Conditions

Hypoglycemia
Gastric Outlet Obstruction
Steatohepatitis
Parenteral Support
Gastric Bypass

Interventions

DEVICE

No Results Yet

NCT05611996 | COMPLETED | NA

34 participants

PEERS Plus mHealth Enhanced Peer Support

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2022-12-15
Completion:: 2025-01-17

Conditions

Depression in Old Age

Interventions

BEHAVIORAL

Results Available

NCT05599269 | COMPLETED | NA

17 participants

Retrospective Clinical Evaluation of Nano-hybrid-composite Denture Teeth

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2022-11-18
Completion:: 2023-04-11

Conditions

Edentulous Mouth
Dental Prosthesis Failure

Interventions

DEVICE

Results Available

NCT05560763 | COMPLETED | NA

50 participants

FlowTriever2 Pulmonary Embolectomy Clinical Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2023-02-14
Completion:: 2024-09-09

Conditions

Pulmonary Embolism

Interventions

DEVICE

Results Available

NCT05524493 | RECRUITING

200 participants

High-field MR Imaging in Migraine, Visual Snow and Epilepsy

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-08
Start Date:: 2025-03-01
Completion:: 2026-06-30

Conditions

Migraine
Epilepsy
Visual Snow Syndrome

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT05461573 | COMPLETED | PHASE3

1542 participants

Efficacy, Safety, and Tolerability of LPRI-CF113 as an Oral Contraceptive in Females

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2022-08-02
Completion:: 2024-08-05

Conditions

Contraception
Change in Bone Mineral Density

Interventions

DRUG

No Results Yet

NCT05420012 | COMPLETED | PHASE4

26 participants

The Effect of Vericiguat on Peripheral Vascular Function, Patient Health Status and Inflammation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2023-05-01
Completion:: 2024-10-24

Conditions

Heart Failure
Heart Failure With Reduced Ejection Fraction (HFrEF)

Interventions

DRUG

Results Available

NCT05418244 | RECRUITING | PHASE2/PHASE3

84 participants

Inhaled Isopropyl Alcohol for Treatment of Nausea

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2022-04-20
Completion:: 2026-06-30

Conditions

Vomiting
Nausea
Children, Only

Interventions

OTHER
DRUG

No Results Yet

NCT05321719 | COMPLETED | NA

228 participants

Multi-Media Parent-based Intervention to Promote Dental Hygiene Among Young Children: BeReady2Smile II

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2023-04-10
Completion:: 2024-04-24

Conditions

Plaque

Interventions

BEHAVIORAL

No Results Yet

NCT05317078 | TERMINATED | PHASE1

3 participants

A Phase 1 Safety, Tolerability, and Pharmacokinetics Study of AMG 794 With Claudin 6-positive Non-small Cell Lung Cancer, Epithelial Ovarian Cancer, and Other Malignant Solid Tumor Indications

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2023-02-28
Completion:: 2023-12-19

Conditions

Non-squamous Non-small Cell Lung Cancer
Epithelial Ovarian Cancer
Claudin 6-positive Advanced/Metastatic Malignant Solid Tumors

Interventions

DRUG

No Results Yet

NCT05307328 | COMPLETED | PHASE2

26 participants

SPI-62 as a Treatment for Adrenocorticotropic Hormone-dependent Cushing's Syndrome

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2022-09-01
Completion:: 2025-08-01

Conditions

Cushing's Syndrome I
Cushing Disease Due to Increased ACTH Secretion
Cortisol Excess
Cortisol; Hypersecretion
Cortisol Overproduction
Ectopic ACTH Secretion

Interventions

DRUG

No Results Yet

NCT05245201 | ACTIVE_NOT_RECRUITING | NA

4 participants

Clinical Decision Support for PrEP

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2022-07-11
Completion:: 2026-08-31

Conditions

HIV Infections
Preexposure Prophylaxis (PrEP)

Interventions

OTHER

No Results Yet

NCT05236192 | COMPLETED | NA

341 participants

New Parent Support Program Evaluation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2023-02-17
Completion:: 2025-08-07

Conditions

Child Maltreatment

Interventions

BEHAVIORAL

No Results Yet

NCT05206331 | RECRUITING | PHASE4

2100 participants

CEM to Reduce Biopsy Rates for Less Than Highly Suspicious Breast Abnormalities: a Prospective Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2022-02-01
Completion:: 2026-11-30

Conditions

Breast Cancer

Interventions

DEVICE
DRUG

No Results Yet

NCT05101746 | ENROLLING_BY_INVITATION | PHASE2/PHASE3

50 participants

Nitric Oxide Effect on Brain and Kidney in Pediatric Patients Undergoing Cardiopulmonary Bypass

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2022-04-25
Completion:: 2026-09-30

Conditions

Congenital Heart Disease
Congenital Heart Defect
Congenital Heart Malformations

Interventions

DRUG
OTHER

No Results Yet

NCT05084521 | COMPLETED | PHASE2/PHASE3

30 participants

Interest of Famotidine in Children With Sickle Cell Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2022-01-12
Completion:: 2022-12-12

Conditions

Sickle Cell Disease

Interventions

DRUG

No Results Yet

NCT05027789 | ACTIVE_NOT_RECRUITING | NA

263 participants

Brain Boosters 2 in Persons at Risk for Alzheimer's Disease: a Digital Application Supported Intervention

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2021-08-13
Completion:: 2026-08-31

Conditions

Memory Disorders
Cognitive Impairment

Interventions

BEHAVIORAL

No Results Yet

NCT04967274 | RECRUITING | NA

248 participants

Reticulospinal Control of Movements

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2022-01-15
Completion:: 2026-06-30

Conditions

Spinal Cord Injuries
Healthy

Interventions

PROCEDURE

No Results Yet

NCT04932447 | ACTIVE_NOT_RECRUITING | NA

122 participants

Breathing Training for Improving Cardiovascular Health in Older Adults With Sleep Apnea

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2021-09-01
Completion:: 2026-06-30

Conditions

Obstructive Sleep Apnea
Hypertension

Interventions

BEHAVIORAL

No Results Yet

NCT04888312 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

94 participants

Safety and Efficacy of Mitazalimab in Combination With Chemotherapy in Pancreatic Cancer Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2021-09-17
Completion:: 2026-06-01

Conditions

Metastatic Pancreatic Ductal Adenocarcinoma

Interventions

BIOLOGICAL

No Results Yet

NCT04859699 | COMPLETED | NA

1095 participants

Reopening Schools Safely and Educating Youth Research Study (ROSSEY)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2022-01-17
Completion:: 2024-05-08

Conditions

Absenteeism

Interventions

BEHAVIORAL

Results Available

NCT04742777 | COMPLETED | PHASE2

20 participants

Effect of mTOR Inhibition & Other Metabolism Modulating Interventions on the Elderly [SubStudy Rapa & cMRI to Evaluate Cardiac Function]

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2022-02-01
Completion:: 2025-09-09

Conditions

Aging

Interventions

DRUG

No Results Yet

NCT04692779 | COMPLETED

60 participants

A Prospective Clinical Study to Explore Response to Prone Positioning in ARDS Patients

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-08
Start Date:: 2021-01-31
Completion:: 2022-01-31

Conditions

Covid19
ARDS

Interventions

OTHER

No Results Yet

NCT04654689 | COMPLETED | PHASE2

90 participants

Impact of the Combined Treatment of Liposomed Polyphenols With G04CB02 on the ALS Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2021-11-20
Completion:: 2022-11-12

Conditions

Amyotrophic Lateral Sclerosis

Interventions

DIETARY_SUPPLEMENT
OTHER
DRUG

No Results Yet

NCT04572243 | TERMINATED | PHASE3

22 participants

A Study of Lorcaserin as Adjunctive Treatment in Participants With Dravet Syndrome

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2020-09-23
Completion:: 2024-08-15

Conditions

Epilepsies, Myoclonic

Interventions

DRUG

Results Available

NCT04539717 | ENROLLING_BY_INVITATION

820 participants

FAST (Focused Abbreviated Screening Technique)-MRI Study

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-08
Start Date:: 2020-08-17
Completion:: 2026-05-31

Conditions

Hepatocellular Carcinoma (HCC)
Liver Cirrhosis

No Results Yet

NCT04479475 | COMPLETED | NA

58 participants

Social Networks and Methadone Maintenance Treatment Retention and Antiretroviral Therapy Retention in Tanzania

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2024-03-01
Completion:: 2024-09-05

Conditions

Opioid-use Disorder
Adherence, Medication
HIV Infections

Interventions

BEHAVIORAL

Results Available

NCT04459715 | TERMINATED | PHASE3

730 participants

A Study of Xevinapant (Debio 1143) in Combination With Platinum-Based Chemotherapy and Standard Fractionation Intensity-Modulated Radiotherapy in Participants With Locally Advanced Squamous Cell Carcinoma of the Head and Neck, Suitable for Definitive Chemoradiotherapy (TrilynX)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2020-08-07
Completion:: 2024-09-18

Conditions

Squamous Cell Carcinoma of the Head and Neck

Interventions

DRUG
RADIATION

Results Available

NCT04438213 | RECRUITING | PHASE2

60 participants

Ertugliflozin in Chronic Heart Failure

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2021-03-10
Completion:: 2025-12-30

Conditions

Heart Failure

Interventions

DRUG

No Results Yet

NCT04370587 | RECRUITING | PHASE1/PHASE2

30 participants

A Clinical Study of Intratumoral MVR-T3011 (T3011) Given as a Single Agent and in Combination With Intravenous Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2020-09-17
Completion:: 2026-09-22

Conditions

Solid Tumor
Melanoma
HNSCC
Sarcoma
Squamous Cell Carcinoma
NSCLC

Interventions

BIOLOGICAL
COMBINATION_PRODUCT

No Results Yet

NCT04323098 | COMPLETED | PHASE3

22 participants

Study to Evaluate the Efficacy and Safety of Valoctocogene Roxaparvovec, With Prophylactic Steroids in Hemophilia A

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2020-12-08
Completion:: 2023-01-27

Conditions

Hemophilia A

Interventions

BIOLOGICAL

Results Available

NCT04189445 | TERMINATED | PHASE2

115 participants

Futibatinib in Patients With Specific FGFR Aberrations

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2020-08-05
Completion:: 2024-11-11

Conditions

Advanced or Metastatic Solid Tumor
Advanced or Metastatic Gastric or Gastroesophageal Cancer
Myeloid or Lymphoid Neoplasms (MLN)

Interventions

DRUG

Results Available

NCT04143243 | COMPLETED | NA

176 participants

One-day Life Skills Workshop for Veterans With TBI, Pain, and Psychopathology: Evaluating Efficacy and Mechanism of Change

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2020-07-01
Completion:: 2024-08-03

Conditions

Traumatic Brain Injury
Chronic Pain
Post Traumatic Stress Disorder
Depression
Anxiety

Interventions

BEHAVIORAL

Results Available

NCT04136951 | COMPLETED | NA

1915 participants

Improving Patient Prioritization During Hospital-homecare Transition

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2023-08-01
Completion:: 2024-04-01

Conditions

Diabetes Mellitus, Type 2
Congestive Heart Failure
Obstructive Pulmonary Disease
Dyspnea
Renal Failure

Interventions

OTHER

Results Available

NCT03959527 | COMPLETED | PHASE3

1011 participants

Zoliflodacin in Uncomplicated Gonorrhoea

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2019-11-06
Completion:: 2023-08-30

Conditions

Gonorrhea

Interventions

DRUG

Results Available

NCT03873467 | ACTIVE_NOT_RECRUITING | NA

65 participants

Group Lifestyle Balance™ for Individuals With Stroke (GLB-CVA)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2019-07-08
Completion:: 2022-12-30

Conditions

Stroke

Interventions

BEHAVIORAL
OTHER

No Results Yet

NCT03821272 | COMPLETED | PHASE1/PHASE2

17 participants

A Phase I/II Clinical Trial of PepCan in Head and Neck Cancer Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2019-11-13
Completion:: 2025-02-03

Conditions

Head and Neck Cancer

Interventions

BIOLOGICAL

Results Available

NCT03817502 | RECRUITING | PHASE3

330 participants

Efficacy and Safety of Cariprazine in the Treatment of Adolescent Participants (13 to 17 Years of Age) With Schizophrenia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2019-06-06
Completion:: 2026-12-15

Conditions

Schizophrenia

Interventions

DRUG

No Results Yet

NCT03692312 | COMPLETED | PHASE2/PHASE3

56 participants

Efficacy and Safety of Tideglusib in Congenital Myotonic Dystrophy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2021-03-03
Completion:: 2023-04-04

Conditions

Congenital Myotonic Dystrophy

Interventions

DRUG

Results Available