Clinical Trials Updated in 2025

NCT04187443 | RECRUITING | PHASE1

45 participants

MS-553 in Diabetic Retinopathy Patients With Central Involved Macular Edema

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-29
Start Date:: 2020-06-02
Completion:: 2026-10-30

Conditions

Diabetic Macular Edema
Macular Edema
Type 2 Diabetes With Diabetic Macular Edema
Type 1 Diabetes With Diabetic Macular Edema
Diabetic Retinopathy

Interventions

DRUG

No Results Yet

NCT04132414 | WITHDRAWN | NA

0 participants

Cerebral NIRS Monitoring During Anesthesia in Neonates and Infants

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-29
Start Date:: 2022-12-31
Completion:: 2023-06-30

Conditions

Cerebral Oxygenation

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04130269 | RECRUITING

100 participants

Anxiety, Stress and Pain & Myocardial Infarction

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-29
Start Date:: 2020-04-07
Completion:: 2027-12-07

Conditions

Myocardial Infarction

Interventions

OTHER

No Results Yet

NCT04121806 | RECRUITING | NA

20 participants

Diet Intervention Treatment for Active Ulcerative Colitis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-29
Start Date:: 2021-03-01
Completion:: 2026-09-30

Conditions

Colitis, Ulcerative

Interventions

OTHER

No Results Yet

NCT04111978 | RECRUITING | PHASE3

540 participants

MAintenance Therapy With Aromatase Inhibitor in Epithelial Ovarian Cancer (MATAO)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-29
Start Date:: 2020-11-05
Completion:: 2027-07-01

Conditions

Ovarian Neoplasm Epithelial
Fallopian Tube Neoplasms
Peritoneal Neoplasms
High-grade Serous Ovarian Carcinoma (HGSOC)
Low-grade Serous Ovarian Carcinoma (LGSOC)
Ovarian Endometrioid Carcinoma

Interventions

DRUG
OTHER

No Results Yet

NCT04103983 | COMPLETED | NA

109 participants

Sensory Retraining for Phantom Limb Pain

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-29
Start Date:: 2024-02-09
Completion:: 2025-05-18

Conditions

Phantom Limb Pain

Interventions

DEVICE

No Results Yet

NCT04087889 | NO_LONGER_AVAILABLE

Individual Patient Expanded Access IND of Hope Biosciences First Blood Relative Allogeneic Adipose-derived Mesenchymal Stem Cells (HB-adMSCs) for Pancreatic Cancer

Study Type:: EXPANDED_ACCESS
Last Updated:: 2025-09-29

Conditions

Pancreatic Cancer

Interventions

BIOLOGICAL

No Results Yet

NCT04064983 | NO_LONGER_AVAILABLE

Individual Patient Expanded Access IND to Treat Polyneuropathy

Study Type:: EXPANDED_ACCESS
Last Updated:: 2025-09-29

Conditions

Polyneuropathies

Interventions

BIOLOGICAL

No Results Yet

NCT04064957 | NO_LONGER_AVAILABLE

Individual Patient Expanded Access IND of Hope Biosciences Autologous Adipose-derived Mesenchymal Stem Cells for Spinal Cord Injury

Study Type:: EXPANDED_ACCESS
Last Updated:: 2025-09-29

Conditions

Spinal Cord Injuries

Interventions

BIOLOGICAL

No Results Yet

NCT04038580 | COMPLETED | NA

29 participants

A Comparative Assessment of Transfemoral Prosthetic Sockets

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-29
Start Date:: 2019-08-15
Completion:: 2024-07-01

Conditions

Amputation
Amputation; Traumatic, Leg, Lower

Interventions

DEVICE

Results Available

NCT04029896 | NO_LONGER_AVAILABLE

Individual Patient Expanded Access IND of Hope Biosciences Autologous Adipose-derived Mesenchymal Stem Cells for the Treatment of Cerebral Palsy

Study Type:: EXPANDED_ACCESS
Last Updated:: 2025-09-29

Conditions

Cerebral Palsy

Interventions

BIOLOGICAL

No Results Yet

NCT03925649 | NO_LONGER_AVAILABLE

Individual Patient Expanded Access IND of Hope Biosciences Autologous Adipose-derived Mesenchymal Stem Cells for Treatment of SCI

Study Type:: EXPANDED_ACCESS
Last Updated:: 2025-09-29

Conditions

Spinal Cord Injury at C5-C7 Level

Interventions

BIOLOGICAL

No Results Yet

NCT03901755 | COMPLETED

151 participants

An International Study to Evaluate the Real-world Effectiveness and Usage of Alprolix in Patients With Haemophilia B

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-29
Start Date:: 2019-09-12
Completion:: 2024-03-12

Conditions

Hemophilia B

Interventions

DRUG

No Results Yet

NCT03857529 | RECRUITING | NA

15 participants

Improving Stroke Motor Control With Non-invasive Brain Stimulation and Functional Electrical Stimulation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-29
Start Date:: 2019-08-01
Completion:: 2028-08-01

Conditions

Stroke
Rehabilitation
Hand

Interventions

DEVICE

No Results Yet

NCT03837483 | ACTIVE_NOT_RECRUITING | PHASE3

10 participants

A Clinical Study to Evaluate the Use of a Cryopreserved Formulation of OTL-103 in Subjects With Wiskott-Aldrich Syndrome

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-29
Start Date:: 2019-01-21
Completion:: 2024-03-18

Conditions

Wiskott-Aldrich Syndrome

Interventions

GENETIC

No Results Yet

NCT03811769 | TERMINATED | NA

335 participants

Large Stroke Therapy Evaluation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-29
Start Date:: 2019-04-07
Completion:: 2023-04-26

Conditions

Stroke

Interventions

OTHER
PROCEDURE

No Results Yet

NCT03722303 | SUSPENDED | EARLY_PHASE1

100 participants

Lipografting Versus Steroid Injections for Treatment of Carpal Tunnel Syndrome

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-29
Start Date:: 2016-12-19
Completion:: 2026-12-31

Conditions

Carpal Tunnel Syndrome

Interventions

OTHER
DRUG

No Results Yet

NCT03581136 | ACTIVE_NOT_RECRUITING | NA

74 participants

Phase II Multi-center Trial Evaluating 5 Fraction Stereotactic Partial Breast Irradiation Using Gammapod

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-29
Start Date:: 2019-04-22
Completion:: 2028-05-25

Conditions

Breast Cancer

Interventions

DEVICE

No Results Yet

NCT03570801 | ACTIVE_NOT_RECRUITING | NA

662 participants

SLIP II Registry: Spinal Laminectomy Versus Instrumented Pedicle Screw Fusion

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-29
Start Date:: 2017-10-17
Completion:: 2028-12-31

Conditions

Lumbar Spondylolisthesis
Grade 1 Spondylolisthesis
Lumbar Spinal Stenosis
Degenerative Spondylolisthesis

Interventions

OTHER

No Results Yet

NCT03560323 | COMPLETED | PHASE1

41 participants

Ketones, Muscle Metabolism, and SGLT2 Inhibitors - Protocol 1

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-29
Start Date:: 2019-01-07
Completion:: 2024-08-30

Conditions

Heart Failure
Type 2 Diabetes Mellitus

Interventions

DRUG

Results Available

NCT03547947 | ACTIVE_NOT_RECRUITING

200 participants

Clinical and Radiological Outcomes of Medacta Shoulder System

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-29
Start Date:: 2018-06-13
Completion:: 2031-04-30

Conditions

Primary Osteoarthritis
Secondary Osteoarthritis
Rotator Cuff Tear Arthropathy
Rheumatoid Arthritis Shoulder
Avascular Necrosis
Fracture
Revision of Shoulder Arthroplasty

Interventions

DEVICE

No Results Yet

NCT03516812 | COMPLETED | PHASE2

36 participants

Testosterone and Olaparib in Treating Patients With Castration-Resistant Prostate Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-29
Start Date:: 2018-08-29
Completion:: 2021-03-05

Conditions

Castration-Resistant Prostate Carcinoma
Prostate Adenocarcinoma

Interventions

OTHER
DRUG

Results Available

NCT03505580 | TERMINATED

500 participants

AMIStem-H Radiological Assessment

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-29
Start Date:: 2013-10-31
Completion:: 2022-12-31

Conditions

Hip Replacement Arthroplasty

No Results Yet

NCT03502447 | TERMINATED | NA

14 participants

Randomized Study of the Safety and Effectiveness of the TearCare System for the Signs and Symptoms of Dry Eye Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-29
Start Date:: 2018-04-20
Completion:: 2018-12-04

Conditions

Dry Eye Syndromes

Interventions

DEVICE

Results Available

NCT03415828 | RECRUITING | NA

230 participants

Ethanol Gel Versus Steroid in Refractory Lumbar Discogenic Pain

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-29
Start Date:: 2018-05-29
Completion:: 2024-02-29

Conditions

Lumbar Discogenic Pain (Disorder)

Interventions

DEVICE
DRUG

No Results Yet

NCT03415412 | ACTIVE_NOT_RECRUITING | NA

18 participants

Clinical Evaluation of Three Different Universal Adhesives in Non-carious Cervical Lesions

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-29
Start Date:: 2016-04-01
Completion:: 2016-06-01

Conditions

Tooth Diseases

Interventions

DEVICE

No Results Yet

NCT03334669 | TERMINATED | NA

4999 participants

Family-centered Obesity Prevention: Communities for Healthy Living (CHL)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-29
Start Date:: 2017-10-01
Completion:: 2019-12-31

Conditions

Pediatric Obesity
Obesity

Interventions

BEHAVIORAL

No Results Yet

NCT03298243 | RECRUITING | NA

30 participants

Use of Sensory Substitution to Improve Arm Control After Stroke

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-29
Start Date:: 2023-07-17
Completion:: 2026-05-31

Conditions

Stroke
Proprioceptive Disorders

Interventions

BEHAVIORAL

No Results Yet

NCT03284346 | TERMINATED | NA

23 participants

Exercise in Targeting Metabolic Dysregulation in Stage I-III Breast or Prostate Cancer Survivors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-29
Start Date:: 2017-08-17
Completion:: 2019-07-15

Conditions

Cancer Survivor
No Evidence of Disease
Obesity
Overweight
Prostate Carcinoma
Sedentary Lifestyle
Stage I Breast Cancer
Stage IA Breast Cancer
Stage IB Breast Cancer
Stage II Breast Cancer
Stage IIA Breast Cancer
Stage IIB Breast Cancer
Stage III Breast Cancer
Stage IIIA Breast Cancer
Stage IIIB Breast Cancer
Stage IIIC Breast Cancer

Interventions

BEHAVIORAL
OTHER

No Results Yet

NCT03264547 | COMPLETED | PHASE3

446 participants

A Study to Compare Eribulin Mesylate + Pertuzumab + Trastuzumab With Paclitaxel or Docetaxel + Pertuzumab + Trastuzumab

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-29
Start Date:: 2017-08-28
Completion:: 2024-12-31

Conditions

Breast Cancer

Interventions

DRUG

No Results Yet

NCT03192007 | NOT_YET_RECRUITING

140 participants

Multi-Parametric MRI for Renal Transplantation

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-29
Start Date:: 2027-07-01
Completion:: 2028-12-31

Conditions

Renal Transplant Rejection

Interventions

DEVICE

No Results Yet

NCT03147885 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

43 participants

Selinexor Plus Combination Chemotherapy in Treating Patients With Advanced B Cell Non-Hodgkin Lymphoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-29
Start Date:: 2017-06-20
Completion:: 2027-12-31

Conditions

Diffuse Large B-Cell Lymphoma
Recurrent B-Cell Non-Hodgkin Lymphoma
Recurrent Extranodal Marginal Zone Lymphoma
Recurrent Follicular Lymphoma
Recurrent Indolent Adult Non-Hodgkin Lymphoma
Recurrent Mantle Cell Lymphoma
Recurrent Marginal Zone Lymphoma
Recurrent Waldenstrom Macroglobulinemia
Refractory B-Cell Non-Hodgkin Lymphoma
Refractory Extranodal Marginal Zone Lymphoma
Refractory Follicular Lymphoma
Refractory Mantle Cell Lymphoma
Stage III Non-Hodgkin Lymphoma
Stage IV Non-Hodgkin Lymphoma
Transformed Recurrent Non-Hodgkin Lymphoma

Interventions

DRUG

No Results Yet

NCT03039855 | COMPLETED | NA

157 participants

Tiara™ Transcatheter Mitral Valve Replacement Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-29
Start Date:: 2017-03-08
Completion:: 2019-12-19

Conditions

Mitral Valve Regurgitation

Interventions

DEVICE

No Results Yet

NCT03039712 | ACTIVE_NOT_RECRUITING

37000 participants

Longitudinal Coverage With Evidence Development Study on Micra Leadless Pacemakers

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-29
Start Date:: 2017-03-10
Completion:: 2029-06-30

Conditions

Bradycardia

No Results Yet

NCT03015896 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

36 participants

Nivolumab and Lenalidomide in Treating Patients With Relapsed or Refractory Non-Hodgkin or Hodgkin Lymphoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-29
Start Date:: 2017-02-14
Completion:: 2026-08-09

Conditions

Grade 3a Follicular Lymphoma
Recurrent Burkitt Lymphoma
Recurrent Diffuse Large B-Cell Lymphoma
Recurrent Follicular Lymphoma
Recurrent Grade 1 Follicular Lymphoma
Recurrent Grade 2 Follicular Lymphoma
Recurrent Lymphoplasmacytic Lymphoma
Recurrent Mantle Cell Lymphoma
Recurrent Marginal Zone Lymphoma
Recurrent Waldenstrom Macroglobulinemia
Refractory Burkitt Lymphoma
Refractory Diffuse Large B-Cell Lymphoma
Refractory Follicular Lymphoma
Refractory Lymphoplasmacytic Lymphoma
Refractory Mantle Cell Lymphoma

Interventions

OTHER
DRUG
BIOLOGICAL

No Results Yet

NCT02962102 | COMPLETED | PHASE2

150 participants

Activated Vitamin D for the Prevention and Treatment of Acute Kidney Injury

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-29
Start Date:: 2017-04-03
Completion:: 2020-07-16

Conditions

Critically Ill
Acute Kidney Injury

Interventions

DRUG

Results Available

NCT02954432 | ACTIVE_NOT_RECRUITING

40 participants

Effects of tDCS and TUS on the Perception of Pain and Functional Limitations Due to Non-Specific Chronic Low Back Pain

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-29
Start Date:: 2016-11-30
Completion:: 2022-11-30

Conditions

Chronic Pain
Chronic Low Back Pain

Interventions

DEVICE

Results Available

NCT02850575 | ACTIVE_NOT_RECRUITING

150 participants

Bone Fixation of Mpact Double Mobility Cup

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-29
Start Date:: 2014-01-31
Completion:: 2030-01-31

Conditions

Total Hip Replacement

Interventions

DEVICE

No Results Yet

NCT02846636 | SUSPENDED

100 participants

Mpact Cup Performance After Total Hip Arthroplasty

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-29
Start Date:: 2014-08-31
Completion:: 2029-04-30

Conditions

Total Hip Replacement

No Results Yet

NCT02748408 | RECRUITING

550 participants

The Medacta International SMS Post-Marketing Surveillance Study

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-29
Start Date:: 2015-07-31
Completion:: 2032-07-31

Conditions

Arthrosis
Traumatic Arthritis
Rheumatoid Polyarthritis
Congenital Hip Dysplasia
Avascular Necrosis of the Femoral Head

Interventions

DEVICE

No Results Yet