Clinical Trials Updated in 2025

NCT04368429 | COMPLETED | PHASE3

360 participants

Study of a Quadrivalent Meningococcal Conjugate Vaccine as a Single Dose Compared With a Single Dose of a Meningococcal Reference Vaccine in Children, Adolescents, and Adults 2 to 55 Years of Age

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2020-05-22
Completion:: 2020-11-07

Conditions

Meningococcal Immunisation (Healthy Volunteers)

Interventions

BIOLOGICAL

Results Available

NCT04294134 | ENROLLING_BY_INVITATION | NA

320 participants

MIO-CPP to Improve the Well-being, Permanency, and Safety Outcomes for Young Children at Risk of or in Out-of-home Placement in Philadelphia and Bucks Counties, and Affected by Maternal Substance Use

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2020-01-02
Completion:: 2027-09-30

Conditions

Substance Use Disorders
Parent-Child Relations
Parent Child Abuse

Interventions

BEHAVIORAL

No Results Yet

NCT04278144 | TERMINATED | PHASE1/PHASE2

175 participants

A First-in-human Study Using BDC-1001 as a Single Agent and in Combination With Nivolumab in Advanced HER2-Expressing Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2020-02-24
Completion:: 2024-12-10

Conditions

HER2-positive Solid Tumors
HER2-positive Breast Cancer
HER2-positive Colorectal Cancer
HER2-positive Gastroesophageal Cancer
HER2-positive Endometrial Cancer

Interventions

DRUG

No Results Yet

NCT04246970 | ENROLLING_BY_INVITATION | NA

60 participants

Prehabilitation and Posttransplant Training Program in Liver Transplantation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2021-04-01
Completion:: 2026-06-30

Conditions

Liver Transplant; Complications
Cirrhosis, Liver
Hepatic Carcinoma

Interventions

OTHER

No Results Yet

NCT04182100 | COMPLETED | PHASE2

29 participants

Efficacy and Safety of P1101 in Polycythemia Vera Patients for Whom the Standard of Treatment is Difficult to Apply

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2019-12-20
Completion:: 2021-03-08

Conditions

Polycythemia Vera (PV)

Interventions

DRUG
PROCEDURE

Results Available

NCT04180215 | COMPLETED | PHASE1/PHASE2

198 participants

A Phase 1/2 Study in Patients With HPV16+ Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma and Other Cancers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2019-12-11
Completion:: 2025-01-09

Conditions

HPV-Related Squamous Cell Carcinoma

Interventions

DRUG

No Results Yet

NCT04163289 | ACTIVE_NOT_RECRUITING | PHASE1

20 participants

Preventing Toxicity in Renal Cancer Patients Treated With Immunotherapy Using Fecal Microbiota Transplantation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2020-01-23
Completion:: 2023-11-28

Conditions

Renal Cell Carcinoma

Interventions

DRUG

No Results Yet

NCT04158297 | COMPLETED | NA

30 participants

ESWL Versus SOPIL for Treatment of Pancreatic Duct Stones

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2019-11-13
Completion:: 2025-09-05

Conditions

Chronic Pancreatitis
Pancreatic Duct Stone

Interventions

PROCEDURE

No Results Yet

NCT04140149 | COMPLETED

26 participants

Living With Hope: A Preliminary Investigation of a Skills Class

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-15
Start Date:: 2021-07-06
Completion:: 2023-08-10

Conditions

Suicide
Suicide, Attempted
Suicidal Ideation

Interventions

BEHAVIORAL

No Results Yet

NCT04135703 | COMPLETED | NA

240 participants

Prevention of OUD: The HOME Project (Housing, Opportunities, Motivation and Engagement)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2020-06-23
Completion:: 2024-05-14

Conditions

Substance Use

Interventions

BEHAVIORAL

Results Available

NCT04124848 | RECRUITING

600 participants

Obstructive Sleep Apnea Among Somali-Americans

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-15
Start Date:: 2019-10-25
Completion:: 2031-12-31

Conditions

Obstructive Sleep Apnea

No Results Yet

NCT04084769 | COMPLETED | PHASE3

570 participants

Study to Evaluate the Immune Response After a Booster Dose of a Quadrivalent Meningococcal (MenACYW) Conjugate Vaccine When Administered Alone or Concomitantly With a Licensed Meningococcal Serogroup B Vaccine, in Participants Who Received Primary Quadrivalent Meningococcal Conjugate Vaccine (MCV4)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2019-09-03
Completion:: 2020-09-14

Conditions

Meningococcal Immunisation (Healthy Volunteers)

Interventions

BIOLOGICAL

Results Available

NCT04071457 | ACTIVE_NOT_RECRUITING | PHASE3

1100 participants

S1803, Lenalidomide +/- Daratumumab/rHuPh20 as Post-ASCT Maintenance for MM w/MRD to Direct Therapy Duration

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2019-08-13
Completion:: 2029-07-01

Conditions

Multiple Myeloma

Interventions

DRUG

No Results Yet

NCT04029363 | RECRUITING | NA

120 participants

Expanded Study of the HighLife 28mm Trans-septal Trans-catheter Mitral Valve in Patients With Moderate-severe or Severe Mitral Regurgitation and at High Surgical Risk

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2019-05-28
Completion:: 2026-12-15

Conditions

Mitral Regurgitation

Interventions

DEVICE

No Results Yet

NCT03995953 | COMPLETED | NA

2150 participants

Integrated Care Delivery of HIV Prevention and Treatment in AGYW in Zambia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2021-05-10
Completion:: 2024-03-11

Conditions

HIV

Interventions

BEHAVIORAL
OTHER

Results Available

NCT03958240 | RECRUITING | NA

1100 participants

Deciphering Mechanisms Underlying Cancer Immunogenicity

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2020-01-17
Completion:: 2033-01-31

Conditions

Head and Neck Cancer
Ovarian Cancer
Cervical Cancer
Cervical Intraepithelial Neoplasia 3
Glioblastoma Multiforme of Brain Stem
Non Small Cell Lung Cancer
Anal Cancer

Interventions

OTHER

No Results Yet

NCT03944499 | COMPLETED | PHASE1

161 participants

Phase 1 Study of FS-1502 in Patients With HER2 Expressed Advanced Solid Tumors and Breast Cancer.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2019-10-11
Completion:: 2024-05-20

Conditions

Solid Tumor
Breast Cancer

Interventions

DRUG

No Results Yet

NCT03940508 | COMPLETED | NA

29 participants

Engaging Black Youth in Depression and Suicide Prevention Treatment Within Urban Schools

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2020-01-31
Completion:: 2023-12-31

Conditions

Depression
Suicidal Ideation

Interventions

BEHAVIORAL

Results Available

NCT03924492 | APPROVED_FOR_MARKETING

Expanded Access Protocol of ZULRESSO™ (Brexanolone) Injection for Adult Patients With Postpartum Depression

Study Type:: EXPANDED_ACCESS
Last Updated:: 2025-09-15

Conditions

Postpartum Depression

Interventions

DRUG

No Results Yet

NCT03912753 | COMPLETED | NA

300 participants

Building Mobile HIV Prevention and Mental Health Support in Low-resource Settings

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2019-05-20
Completion:: 2024-01-31

Conditions

Human Immunodeficiency Virus
Risk Reduction
Alcohol Abuse
Depression, Anxiety
Behavior, Sex

Interventions

BEHAVIORAL
OTHER

Results Available

NCT03890367 | COMPLETED | PHASE3

707 participants

Study on a Quadrivalent Meningococcal Conjugate Vaccine (MenACYW Conjugate Vaccine) Compared to Two Meningococcal Reference Vaccines in European Toddlers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2019-09-12
Completion:: 2020-10-14

Conditions

Meningococcal Immunisation (Healthy Volunteers)

Interventions

BIOLOGICAL

Results Available

NCT03889119 | ACTIVE_NOT_RECRUITING | NA

100 participants

Stereotactic Body Radiation Therapy (SBRT) for Prostate Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2016-10-21
Completion:: 2023-12-31

Conditions

Prostate Cancer

Interventions

RADIATION

No Results Yet

NCT03865836 | AVAILABLE

Expanded Access for ATB200/AT2221 for the Treatment of Pompe Disease

Study Type:: EXPANDED_ACCESS
Last Updated:: 2025-09-15

Conditions

Pompe Disease

Interventions

BIOLOGICAL
DRUG

No Results Yet

NCT03778931 | COMPLETED | PHASE3

478 participants

Phase 3 Trial of Elacestrant Versus Standard of Care for the Treatment of ER+/HER2- Advanced Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2019-05-10
Completion:: 2021-08-24

Conditions

Breast Cancer

Interventions

DRUG

Results Available

NCT03773900 | COMPLETED | NA

19 participants

Characterization of Gut Microbiota Composition and Activity After a Daily Supplementation of 4.5 g/Day of ChitinGlucan Fibre During 3 Weeks in At-cardiometabolic Risk Volunteers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2018-11-07
Completion:: 2019-06-06

Conditions

Cardiometabolic Risk
Abdominal Obesity

Interventions

DIETARY_SUPPLEMENT

No Results Yet

NCT03770156 | COMPLETED

14 participants

Terrorist Attack - Continuity of Care

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-15
Start Date:: 2020-01-22
Completion:: 2020-10-22

Conditions

Post-Traumatic Stress Disorder
Major Depressive Episode

Interventions

BEHAVIORAL

No Results Yet

NCT03756558 | COMPLETED | NA

147 participants

Cross-Seal Closure Device IDE Trial - Study of the Cross-SealTM Suture-Mediated Vascular Closure Device System

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2019-08-09
Completion:: 2021-03-22

Conditions

Vascular Closure

Interventions

DEVICE

Results Available

NCT03716934 | COMPLETED | PHASE4

196 participants

CRyoAblation vs AntiaRrhythmic Drugs for Persistent Atrial Fibrillation Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2018-06-27
Completion:: 2022-04-18

Conditions

Atrial Fibrillation

Interventions

DEVICE
DRUG

No Results Yet

NCT03665038 | COMPLETED | PHASE3

28 participants

A Study to Assess the Safety of Brexanolone in the Treatment of Adolescent Female Participants With Postpartum Depression (PPD)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2018-09-07
Completion:: 2021-01-08

Conditions

Post Partum Depression

Interventions

DRUG

Results Available

NCT03633396 | COMPLETED | PHASE2

59 participants

A Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in Adults With Palmoplantar Pustulosis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2019-05-20
Completion:: 2021-04-23

Conditions

Palmoplantar Pustulosis

Interventions

BIOLOGICAL
DRUG

Results Available

NCT03621631 | COMPLETED | NA

15 participants

Effect of Tai Chi Exercise on Mechanical Joint Loading in Knee Osteoarthritis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2018-08-27
Completion:: 2024-07-31

Conditions

Knee Osteoarthritis

Interventions

BEHAVIORAL

No Results Yet

NCT03604692 | COMPLETED | PHASE1/PHASE2

41 participants

A Phase 1/2 Study to Evaluate Axatilimab in Participants With Active cGVHD

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2018-11-01
Completion:: 2022-08-12

Conditions

Chronic Graft-versus-host-disease

Interventions

DRUG

Results Available

NCT03527420 | RECRUITING | NA

80 participants

DNA Methylation and Vascular Function

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2019-10-11
Completion:: 2026-06-30

Conditions

Obesity
Vascular Dysfunction

Interventions

OTHER

No Results Yet

NCT03508219 | TERMINATED | NA

130 participants

POLish Bifurcation Optimal Treatment Strategy Study for Left Main Bifurcation Percutaneous Coronary Intervention (PCI)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2018-08-10
Completion:: 2021-04-15

Conditions

Coronary Stenosis

Interventions

DEVICE

Results Available

NCT03480737 | COMPLETED | NA

14 participants

Brain Stimulation for Working Memory Deficits in Adolescents With ADHD

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2019-11-01
Completion:: 2023-03-30

Conditions

ADHD With Working Memory Deficits

Interventions

DEVICE

No Results Yet

NCT03444714 | COMPLETED | PHASE1

32 participants

Phase I Study of RiMO-301 With Radiation in Advanced Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2018-04-10
Completion:: 2025-06-16

Conditions

Advanced Tumors

Interventions

DRUG

No Results Yet

NCT03440970 | COMPLETED | EARLY_PHASE1

20 participants

Mechanism and Effects of Manipulating Chloride Homeostasis in Stable Heart Failure

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2019-01-15
Completion:: 2025-08-30

Conditions

Decompensated Heart Failure

Interventions

DRUG
OTHER

No Results Yet

NCT03434184 | COMPLETED

6 participants

Study of Walk in Patients With Pelvic Fixation

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-15
Start Date:: 2018-10-12
Completion:: 2023-03-16

Conditions

Scoliosis

No Results Yet

NCT03413423 | ACTIVE_NOT_RECRUITING | NA

233 participants

Post Acute Cardiac Event Smoking (PACES) Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2018-01-29
Completion:: 2024-05-08

Conditions

Acute Coronary Syndrome
Tobacco Use

Interventions

BEHAVIORAL

No Results Yet

NCT03366077 | COMPLETED | NA

140 participants

Evaluating the Effect of the Probiotic on Recurrent Urinary Tract Infection in Adult Women

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2017-12-13
Completion:: 2019-07-12

Conditions

Recurrent Urinary Tract Infection in Adult Women

Interventions

DIETARY_SUPPLEMENT

Results Available