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ALDH2 rs671, Alcohol Use, and Health Education in University Students

NCT07802613 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 622

Last updated 2026-09-03

No results posted yet for this study

Summary

Alcohol intolerance is common in East Asian populations and is strongly influenced by the rs671 variant in the ALDH2 gene. This study examined the associations of ALDH2 genotype with drinking behavior and alcohol-related reactions among Taiwanese university students. Participants with previous alcohol exposure underwent rs671 genotyping and received their individual genotype results together with the same standardized health education materials about alcohol intolerance and related health risks. Drinking behavior, knowledge, and attitudes were assessed before and one month after the intervention. The study also evaluated whether facial flushing and rapid heartbeat could help identify ALDH2 deficiency. Changes over the one-month period were evaluated overall and by genotype group.

Conditions

  • Alcohol Intolerance
  • Alcohol Drinking in College
  • Aldehyde Dehydrogenase-2 (ALDH2) Deficiency

Interventions

BEHAVIORAL

Individual ALDH2 Genotype Feedback

Participants underwent ALDH2 rs671 genotyping and received an individual report indicating their rs671 genotype (GG, GA, or AA) and corresponding ALDH2 metabolic status. No individualized health education was provided based on genotype.

BEHAVIORAL

Standardized Alcohol Health Education

All participants received the same standardized health education materials concerning alcohol metabolism, symptoms of alcohol intolerance, and health risks associated with alcohol use and ALDH2 deficiency. The educational content was not individualized according to genotype.

Sponsors & Collaborators

  • National Taiwan University Hospital

    lead OTHER

Principal Investigators

  • Po-Hsiu Kuo, PhD · National Taiwan University

Study Design

Allocation
NA
Purpose
PREVENTION
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-01-09
Primary Completion
2022-05-24
Completion
2022-05-24

Countries

  • Taiwan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07802613 on ClinicalTrials.gov