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Preoperative Ivabradine Doses for Hemodynamic Stability in FESS

NCT07797946 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2026-09-01

No results posted yet for this study

Summary

This study compares two different preoperative doses of a heart-rate-lowering medication called ivabradine in patients undergoing endoscopic sinus surgery under general anesthesia. Patients will receive either a lower dose, a higher dose, or a placebo (inactive pill) before surgery. The goal is to see which approach best keeps blood pressure and heart rate stable during surgery, and whether it reduces bleeding and improves the surge

Conditions

  • Hemodynamic Instability

Interventions

DRUG

Ivabradine 5 mg/5 mg regimen

Oral ivabradine 5 mg administered the night before surgery, followed by an additional 5 mg on the morning of surgery.

DRUG

Ivabradine 5 mg/7.5 mg regimen

Oral ivabradine 5 mg administered the night before surgery, followed by an additional 7.5 mg on the morning of surgery.

DRUG

Placebo

Oral placebo (folic acid) administered the night before surgery and on the morning of surgery, following the same schedule as the treatment groups.

Sponsors & Collaborators

  • Minia University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
21 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-08-01
Primary Completion
2027-02-01
Completion
2027-02-01

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Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07797946 on ClinicalTrials.gov