Greater Occipital Nerve Blockade in Veterans With Post-concussion Headache: Sub-study 2

NCT07796074 · Status: RECRUITING · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 36

Last updated 2026-08-31

No results posted yet for this study

Summary

Anesthetic greater occipital nerve (GON) blockade is a simple, inexpensive, and safe procedure that has demonstrable headache pain suppressing effects. In this study, Veterans with post-traumatic headache will be randomized to receive 0.0%, 0.05%, or 0.5% bupivacaine in bilateral GON blocks and the lasting (i.e., transitional) effects on headache frequency measured in a headache diary.

Conditions

Post-Traumatic Headache

Interventions

OTHER

Bupivacaine bilateral greater occipital nerve block

Three subcutaneous injections of 1 mL each will be injected on both sides of the occipital region around the greater occipital nerve.

Sponsors & Collaborators

VA Connecticut Healthcare System
collaborator FED
National Headache Foundation
collaborator UNKNOWN
Yale University
lead OTHER

Principal Investigators

Emmanuelle Schindler, MD, PhD · VA Connecticut Healthcare System

Study Design

Allocation: RANDOMIZED
Purpose: TREATMENT
Masking: TRIPLE
Model: PARALLEL

Eligibility

Min Age: 18 Years
Sex: ALL
Healthy Volunteers: No

Timeline & Regulatory

Start: 2026-09-01
Primary Completion: 2027-09-30
Completion: 2027-12-31
FDA Drug: Yes

Countries

United States