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Pancreatic Cancer Lifestyle Evolution And Resistance

NCT07794969 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 150

Last updated 2026-08-31

No results posted yet for this study

Summary

Advanced PDAC patients undergo polychemotherapy, yet responses are highly variable. Transcriptome signatures are emerging as key predictors of treatment response. However, PDAC adapts across sites (primary vs. metastases) and evolves under treatment pressure (pre- vs. post-chemotherapy). Moreover, common environmental pollutants, like smoking and microplastics, contribute to carcinogenesis, yet their impact on PDAC evolution and treatment response remains unclear.

To fill these gaps, the CLEAR project aims at investigating:

1. transcriptome patterns linked to treatment response;
2. effects of smoking and microplastic exposure on treatment outcomes;
3. PDAC evolution across organ sites and under chemotherapy. These studies will help uncover biomarkers and factors shaping disease progression, hence paving the ground for personalized therapies.

Conditions

Interventions

PROCEDURE

Endoscopic Ultrasound with FNA/FNB

After identification of the mass lesion, a tumor sample will be acquired with a standard FNA/FNB needle, as the standard procedure requires. The sample will be taken and stored in a Eppendorf Tube of 1.5ml pre-filled with 300μL 1-Thioglycerol/Homogenization solution \_Promega® then stored in a 80°C freezer and transferred every 2 weeks to the CRB for subsequent RNA-seq.

Sponsors & Collaborators

  • IRCCS San Raffaele

    lead OTHER

Principal Investigators

  • Laura Apadula, Nurse · IRCCS San Raffaele

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-10-31
Primary Completion
2029-10-31
Completion
2029-10-31

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07794969 on ClinicalTrials.gov