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Multimodal Laser Treatment of Photodamaged Skin

NCT07789002 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 35

Last updated 2026-08-27

No results posted yet for this study

Summary

The Multimodal Laser Project is a prospective, randomized, split-face clinical study investigating a novel combination of laser and light-based treatments for facial photodamage with the long-term perspective of improving skin cancer prevention.

The study includes 35 patients with facial photodamage and AKs. One side of the face receives a multimodal treatment combining three complementary technologies: 1927-nm thulium laser, 1550-nm non-ablative fractional laser, and intense pulsed light (IPL), while the contralateral side serves as an untreated control.

Participants are followed for 14 months to assess both clinical efficacy and longer-term preventive effects.

The overall aim is not only to determine whether multimodal laser treatment improves photodamaged skin, but also to gain a deeper understanding of how the treatment affects the underlying biology of chronically sun-damaged skin and its potential role in skin cancer prevention.

Conditions

  • Photo-damage
  • Actinic Keratosis (AK)

Interventions

DEVICE

1927-nm thulium laser

Fractional non-ablative 1927-nm thulium laser treatment applied to the randomized intervention side of the face

DEVICE

1550-nm Er:Glass laser

Fractional non-ablative 1550-nm Er:Glass laser treatment applied to the randomized intervention side of the face

DEVICE

Intense Pulsed Light

Intense pulsed light treatment applied to the randomized intervention side of the face

Sponsors & Collaborators

  • Merete Haedersdal

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-09-01
Primary Completion
2028-12-31
Completion
2028-12-31
FDA Device
Yes

Countries

  • Denmark

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07789002 on ClinicalTrials.gov