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Seaweed Extract (Fucoidan) for Gut Inflammation in Ulcerative Colitis

NCT07786389 · Status: ENROLLING_BY_INVITATION · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 90

Last updated 2026-08-26

No results posted yet for this study

Summary

What is the research question being addressed? Does combining Turbinaria ornata-derived fucoidan with standard therapy lead to a significantly higher rate of gut health restoration-defined by increased fecal short-chain fatty acid (butyrate/acetate) levels, reduced fecal calprotectin, and improved stool consistency-compared to standard therapy alone in Ulcerative Colitis patients? Type of study: Interventional Study design: Randomized controlled trial Masking: Participants Control: Placebo Assignment: Parallel Purpose: Other Adjuvant / Add-On Therapy (Complementary Prebiotic Strategy) Study Phase: Phase1

Conditions

  • Ulcerative Colitis (UC)

Interventions

DIETARY_SUPPLEMENT

Low molecular weight fucoidan and standard care

LMWF + 5-ASA Arm Oral administration of 85% purified, dehydrogenated low-molecular-weight fucoidan (\<40 kDa) at a weight-based dose (35 mg/kg/day for active flare) as an adjuvant to standard-of-care 5-aminosalicylate therapy.

OTHER

Placebo and standard of care

placebo and 5 Aminosalicylic acid

Sponsors & Collaborators

  • Allama Iqbal Medical College

    lead OTHER

Principal Investigators

  • Rozina Shahadat Khan, MBBS, M.PHIL,MSPH, CHPE,PHDHND · Saglik Bilimleri Universitesi

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
64 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-08-31
Primary Completion
2027-06-30
Completion
2027-12-31

Countries

  • Pakistan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07786389 on ClinicalTrials.gov