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Response-adapted Postoperative Radiotherapy In Locally Advanced Head and Neck Cancer

NCT07780877 · Status: NOT_YET_RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 85

Last updated 2026-08-24

No results posted yet for this study

Summary

This was a phase II clinical study. Patients with histologically confirmed, resectable, locally advanced head and neck squamous cell carcinoma (HNSCC) without distant metastasis were enrolled. Enrolled patients received three cycles of neoadjuvant immunotherapy combined with chemotherapy. Radical surgery was performed 3-5 weeks after completion of the third neoadjuvant cycle, with the requirement of achieving negative surgical margins (R0 resection). Adjuvant radiotherapy was administered based on postoperative pathological findings.

Conditions

  • Head & Neck Squamous Cell Carcinoma
  • Locally Advanced Head and Neck Squamous Cell Carcinoma

Interventions

RADIATION

Standard adjuvant radiotherapy based on pathologic findings

Standard adjuvant radiotherapy based on pathologic findings

RADIATION

De-escalated radiotherapy with a reduced dose

De-escalated radiotherapy: reduce the dose of elective nodal irradiation (ENI).

RADIATION

De-escalated radiotherapy with omission of ENI

De-escalated radiotherapy: omit elective nodal irradiation (ENI).

Sponsors & Collaborators

  • Hunan Cancer Hospital

    collaborator OTHER

  • Fudan University

    lead OTHER

Principal Investigators

  • Yu Wang, M.D. · Fudan University

  • Xiaomin Ou, M.D. · Fudan University

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-08-31
Primary Completion
2030-08-31
Completion
2030-08-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07780877 on ClinicalTrials.gov