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The Effect of 5-hydroxytryptophan on ADHD Traits and Eye Movements

NCT07777328 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 150

Last updated 2026-08-20

No results posted yet for this study

Summary

The aim of this project is to look at the impact of 5-Hydroxytryptophan (5-HTP) on distractibility. 5-HTP is the precursor to the neurotransmitter serotonin and is a chemical that the body produces naturally. There is evidence that distractibility is associated with a decreased level of serotonin. This research aims to see if giving people 5-HTP will alter their distractibility, which will form part of an initial assessment as to whether 5-HTP could be used to support people with attention problems. The study involves completing a short survey about mental health and behaviours, and if eligible, participation in an in-person study at the University of Sheffield. The in-person session involves completing some cognitive tasks to look at eye movement, taking 5-HTP or a sugar tablet with no active ingredients, and then completing the tasks again after a 90-minute wait.

Conditions

  • Attention Deficit and Hyperactivity Disorder (ADHD)
  • Attention Deficit Hyperactivity Disorder in Adults
  • Attention Deficits

Interventions

DIETARY_SUPPLEMENT

5-hydroxytryptophan (food supplement) 200mg

200mg 5-HTP delivered in two tablets. Tablets obtained from Nature's Best supplements. Each tablet contains 3982mg of Griffonia seed extract, providing 100mg of 5-HTP. The tablets consist of calcium carbonate, griffonia seed extract, Anti-caking Agents (Silicon Dioxide, Stearic Acid, \& Magnesium Stearate) and Tablet Coating (Hydroxypropyl Methylcellulose, Glycerol).

DIETARY_SUPPLEMENT

5-hydroxytryptophan (food supplement) 300mg

300mg 5-HTP delivered in three tablets. Tablets obtained from Nature's Best supplements. Each tablet contains 3982mg of Griffonia seed extract, providing 100mg of 5-HTP. The tablets consist of calcium carbonate, griffonia seed extract, Anti-caking Agents (Silicon Dioxide, Stearic Acid, \& Magnesium Stearate) and Tablet Coating (Hydroxypropyl Methylcellulose, Glycerol).

OTHER

Placebo

Unmedicated lactose-sucrose tablets provided by Ainsworth's homoeopathic remedies

Sponsors & Collaborators

  • University of Sheffield

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-11-25
Primary Completion
2027-02-28
Completion
2027-06-30

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07777328 on ClinicalTrials.gov