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Subcutaneous Methadone for Cesarean Analgesia: a Non Inferiority Study Using QoR-10

NCT07777029 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 128

Last updated 2026-08-20

No results posted yet for this study

Summary

This study aims to evaluate whether subcutaneous methadone provides postoperative analgesia that is non-inferior to that achieved with intrathecal morphine in women undergoing cesarean delivery under neuraxial anesthesia. The primary outcome will be the quality of postoperative recovery, assessed using the QoR-10 score during the first 24 hours after surgery. Secondary outcomes will include postoperative pain intensity, opioid consumption, incidence of adverse effects, and maternal satisfaction.

This trial seeks to determine whether subcutaneous methadone could represent an alternative analgesic strategy within multimodal analgesia protocols for cesarean delivery.

Conditions

  • Cesarean Section Pain

Interventions

DRUG

Methadone 0.15 mg/kg

Subcutaneous methadone administered for postoperative analgesia following cesarean delivery under neuraxial anesthesia.

DRUG

morphine

Intrathecal morphine administered during neuraxial anesthesia for postoperative analgesia following cesarean delivery.

Sponsors & Collaborators

  • Clinica Alemana de Santiago

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-08-21
Primary Completion
2026-12-31
Completion
2027-03-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07777029 on ClinicalTrials.gov