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Evaluation of Psychophysical Responses After Mechanical Stimulation.

NCT07774429 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 33

Last updated 2026-08-24

No results posted yet for this study

Summary

This study evaluates the test-retest reliability of psychophysical responses to non-injurious sharp stimuli applied via a robotic system. The accurate assessment of acute mechanical pain, such as the pain associated with surgical incisions or non-suicidal self-injury, is challenging due to the subjectivity of pain and the risk of tissue damage with traditional mechanical stimulation methods. To overcome this barrier, researchers have developed a non-injurious sharp blade model that mimics the sensory characteristics of incisional pain without causing tissue damage. However, manual application of this blade introduces operator-dependent variability in force, speed, and duration. This study utilizes a novel robotic stimulator equipped with a non-injurious blade to deliver controlled stimuli. The experimental design involves healthy adult volunteers with two identical testing sessions separated by a minimum interval of 48 hours. During these sessions, participants undergo quantitative sensory testing (QST), including the evaluation of pain and tolerance thresholds using the robotic system on the ventral forearm. Additional measurements include pain threshold to pinprick stimulation, muscle stiffness, pain catastrophizing (Sullivan et al., 1995), and conditioned pain modulation.

These results will establish the precision and reliability of this robotic system that are required for further clinical and experimental pain research.

Conditions

  • Pain Thresholds
  • Healthy Adult Participants

Interventions

OTHER

Robot-controlled non-injurious mechanical stimulation

Application of controlled mechanical stimuli using a robotic system equipped with a non-injurious blade head (4 mm x 0.1 mm). The system applies progressive force at a constant speed of 5 mm/s on the ventral forearm to determine pain and tolerance thresholds.

Sponsors & Collaborators

  • Universidad Nacional de Entre Rios

    collaborator OTHER

  • National Council of Scientific and Technical Research, Argentina

    lead OTHER_GOV

Principal Investigators

  • Christian Mista · National Council of Scientific and Technical Research, Argentina

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-06-01
Primary Completion
2026-08-01
Completion
2026-08-01

Countries

  • Argentina

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07774429 on ClinicalTrials.gov