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School-aged Outcomes Post Hypoxic Ischaemic Encephalopathy

NCT07770035 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 196

Last updated 2026-08-18

No results posted yet for this study

Summary

Neonatal HIE increases the risk for cognitive impairments in childhood. Neonatal MRI brain scans are a strong predictor for outcome, however a normal scan has only a 35% sensitivity and 85% specificity for a normal outcome. This may be explained by variability in the brain's development over time in response to the initial insult.

This project will aim to develop a neonatal MRI machine learning algorithm that incorporates both initial injury and radiomic features associated with future brain development (based on school-age MRI) to predict school-age outcome. This will be achieved by conducting a case-control cohort study looking at School-age MRI and outcomes of children with a history of neonatal HIE.

Conditions

  • Hypoxic-Ischemic Encephalopathy

Sponsors & Collaborators

  • University College Cork

    lead OTHER

Principal Investigators

  • Brian H Walsh, PhD · University College Cork

Eligibility

Min Age
5 Years
Max Age
12 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-03-09
Primary Completion
2027-12-31
Completion
2028-12-31

Countries

  • Ireland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07770035 on ClinicalTrials.gov