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Subclinical Myocardial Dysfunction in Children With Wilson's Disease

NCT07765472 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 72

Last updated 2026-08-14

No results posted yet for this study

Summary

Wilson's disease (WD) is one of the most common metabolic liver diseases in older children. The most frequent clinical presentation is liver disease. However, Wilson's disease (WD) is a multisystem disorder. It is concluded that four modes of cardiac manifestations in Wilson's disease (WD) include arrhythmias, cardiomyopathy, cardiac death, and autonomic dysfunction. Such possible cardiac involvement should be added to the clinical picture of Wilson's disease (WD) involving the hepatic and central nervous system(CNS).

The data on cardiac manifestations in children is very limited and only few adult studies are available.

In this study, the investigators aim to unveil subclinical cardiac dysfunction in children with Wilson's disease with apparently normal cardiac functions by conventional assessment.

Conditions

  • Wilson's Disease
  • Myocardial Dysfunction
  • Children
  • Wilson Disease
  • Speckle Tracking Echocardiography
  • Electrocardiographic Changes

Interventions

DEVICE

Echocardiography

a safe, painless test that uses sound waves to create moving pictures of your heart's structure and pumping function.

DEVICE

Electrocardiography

a quick, painless test that records the electrical signals in the heart.

DIAGNOSTIC_TEST

N-terminal pro b- type natriuretic peptide

a protein made by our heart, examined by peripheral blood sample.

Sponsors & Collaborators

  • Hebatullah Fawzy

    lead OTHER

Principal Investigators

  • Hebatullah I Fawzy, Msc Student · Faculty of medicine AinShams U,National Hepatology and Tropical Research Institute (NHTMRI)

  • Eman M ElSayed (Assistant Professor of Pediatrics), AssProfessor · Faculty of Medicine AinShams U

  • Mona AH Khafagy (Lecturer of Pediatrics), Lecturer · Faculty of Medicine AinShams U

  • Sara M Osman (Teaching Fellow of Pediatrics), PedFellow · National Hepatology and Tropical Research Institute (NHTMRI)

Eligibility

Min Age
4 Years
Max Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-10-01
Primary Completion
2026-10-30
Completion
2026-11-30

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07765472 on ClinicalTrials.gov