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Comparing Facial Aging Between Identical Twins With 3D Imaging

NCT07760532 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2026-08-12

No results posted yet for this study

Summary

Identical twins share the same genes, which makes them a powerful way to study how lifestyle and environment - rather than genetics - affect how faces age. This study builds on a landmark 2009 twin study by using modern three-dimensional (3D) facial imaging, which measures facial shape and volume precisely instead of relying on regular photographs. The study will also look at whether use of GLP-1 weight-loss medications (such as semaglutide or tirzepatide), sometimes associated with facial changes informally called "Ozempic face," is related to measurable differences in facial aging.

The study will enroll adult identical twin pairs attending the Twins Days Festival in Twinsburg, Ohio, in August 2026. Participation takes about 30 minutes and happens in a single visit at the festival study booth. Each twin will complete a questionnaire about lifestyle, environment, and medical history (such as sun exposure, smoking, sleep, and medication use) and have a 3D image of their face taken with a non-contact camera system. There is no treatment, no medication, no blood draw or biological sample, and no follow-up visit. Researchers will then compare facial measurements within each twin pair to learn which lifestyle and environmental factors are linked to visible facial aging.

Conditions

  • Facial Skin Aging
  • Facial Volume Loss
  • Wrinkle Appearance

Interventions

DRUG

GLP-1 Receptor Agonists

Self-reported current or prior use of GLP-1 receptor agonist or other rapid weight-loss medication, recorded by participant questionnaire. No medication is administered, assigned, dispensed, or modified by the study; use is observed as a naturally occurring exposure. For the secondary objective, twin pairs discordant for self-reported GLP-1 receptor agonist use are compared with respect to midface and lower-face volume and contour.

Sponsors & Collaborators

  • Ponsky Facial Aesthetics And Plastic Surgery, Llc

    lead INDUSTRY

Principal Investigators

  • Dr. Diana Ponsky, MD, FACS · Ponsky Facial Aesthetics And Plastic Surgery, Llc

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-08-08
Primary Completion
2026-09-30
Completion
2026-09-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07760532 on ClinicalTrials.gov