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Adapted Cardiopulmonary Resuscitation Study

NCT07754656 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 216

Last updated 2026-08-10

No results posted yet for this study

Summary

The goal of this controlled single centre RCT is to compare frequency rates concerning return of spontaneous circulation (ROSC) in prehospital cardiac arrest. Two different algorithms (control-and interventiongroup) of advanced cardiac life support will be used to treat patients. In patients over 18 years suffering from cardiac arrest. The main question aims to answer if the frequency of ROSC differs between the groups receiving either the new Advanced Life Support (ALS) algorithm, or standard treatment.

Researchers will compare the new algorithm to the standard care algorithm to see if there is a difference .

Participants will be randomized to treatment on scene. The controlgroup will receive ALS standard treatment as performed in local protocols.

The intervention group will receive a modified treatment including:

* thorax compression via mechanical device (LUCAS 3)
* head up Cardiopulmonary Resuscitation (cpr)
* use of an impendance threshold device (ITD) module
* arterial line placement
* continuous epinephrin infusion via infusion pump
* double sequence defibrillation

Conditions

  • Cardiac Arrest (CA)

Interventions

PROCEDURE

aCPR algorithm

* thorax compression via mechanical device (LUCAS 3) * head up cpr * use of an ITD module * arterial line placement * continuous epinephrin infusion via infusion pump * double sequence defibrillation

PROCEDURE

ERC ALS 2025

Placement of an IV line, placement of a supraglottic airway device or endotracheal intubation. Optional use of an intraosseus acces

Sponsors & Collaborators

  • Red Cross Upper Austria

    collaborator UNKNOWN

  • Kepler University Hospital

    collaborator OTHER

  • Johannes Kepler University of Linz

    lead OTHER

Principal Investigators

  • Jens Meier, Univ. Prof. · Kepler University Hospital / Johannes Kepler University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-01-28
Primary Completion
2029-01-28
Completion
2029-03-28

Countries

  • Austria

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07754656 on ClinicalTrials.gov