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Impact of Cannabis Use and Abstinence on Emotion

NCT07746440 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2026-08-05

No results posted yet for this study

Summary

The goal of this experimental study is to test how three weeks of cannabis abstinence impacts threat and reward processing in females with Cannabis Use Disorder. The main questions it aims to answer are:

Compared to using cannabis as usual, will cannabis cue reactivity increase throughout three weeks of abstinence from cannabis?

Compared to using cannabis as usual, will threat reactivity be elevated at weeks 1 and 2 of abstinence followed by a decrease at week 3 of abstinence?

Compared to using cannabis as usual, will non-drug reward reactivity be lower at weeks 1 and 2 of abstinence followed by an increase at week 3 of abstinence?

Compared to successful 3-week abstainers, will threat, non-drug reward, and cannabis cue reactivity differ in relapsers?

Researchers will compare females with CUD who abstain from cannabis for three weeks to those who continue to use cannabis as usual to see how cannabis abstinence impacts threat and reward processing.

Participants will:

Be randomly assigned to continue using cannabis as usual or abstain from cannabis for three weeks Visit the lab 6 times over three weeks, followed by a 1-month follow-up lab visit for the participants assigned to the cannabis abstinence condition Complete phone surveys every other day across the three week study period

Conditions

  • Cannabis Use Disorder, Severe

Interventions

BEHAVIORAL

Contingency management for cannabis abstinence and lab visit attendance

Escalating monetary reinforcement is provided for continuous cannabis abstinence and lab visit attendance across the three week study period.

BEHAVIORAL

Contingency management for lab visit attendance

Escalating monetary reinforcement is provided for lab visit attendance across the three week study period.

Sponsors & Collaborators

  • Auburn University

    collaborator OTHER

  • Florida State University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
30 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-01-24
Primary Completion
2024-07-15
Completion
2024-07-15

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07746440 on ClinicalTrials.gov