Precision Lifestyle Medicine Program for IFHAS Participants

Summary

The goal of this clinical trial is to evaluate whether a precision lifestyle medicine intervention can improve cardiometabolic health in Emirati adults aged 25 to 50 years living in Abu Dhabi with obesity (BMI 30-35 kg/m²) who have previously completed IFHAS screening. The study will also use IFHAS screening data to better understand participants' health profiles and the relationship between lifestyle factors and chronic diseases. The main questions it aims to answer are:

* Does a precision lifestyle medicine program improve cardiometabolic biomarkers after an 18-week intervention?
* Can IFHAS screening data be used to identify health risk profiles and support personalized lifestyle interventions for the Emirati population?

Researchers will compare participants receiving the precision lifestyle medicine intervention with a propensity-matched control group receiving standard IFHAS care to determine whether the intervention leads to greater improvements in cardiometabolic health.

Participants will:

* Take part in an 18-week personalized lifestyle medicine program tailored to their health profile.
* Attend study visits and complete health assessments over a total study period of 24 weeks.
* Undergo cardiometabolic biomarker assessments before and after the intervention.
* Complete questionnaires or assessments about their adherence to the lifestyle program and their experience with the precision lifestyle medicine clinic.
* Provide biological samples to support the establishment of a biomarker repository for future research.

Conditions

• Obese Adults
• BMI/Body Composition
• Cardiometabolic Risk
• Cardiovascular Disease Risk
• Type 2 Diabetes Risk

Interventions

BEHAVIORAL

Precision Lifestyle Medicine Program

Participants receive an 18-week precision lifestyle medicine intervention based on individual IFHAS screening results and cardiometabolic risk stratification. The program includes personalized lifestyle recommendations and multidisciplinary clinical support focused on improving cardiometabolic health. Participants are followed for 24 weeks, with assessments conducted at baseline and post-intervention.

OTHER

Standard IFHAS Care

Participants receive standard IFHAS care without participation in the precision lifestyle medicine intervention. This group serves as a propensity score-matched comparison cohort.

Sponsors & Collaborators

• Abu Dhabi Public Health Centre

  collaborator OTHER_GOV

• Institute for Healthier Living Abu Dhabi

  lead OTHER

Principal Investigators

• Nicole Sirotin, MD · Institute for Healthier Living Abu Dhabi

Study Design

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

25 Years

Max Age

50 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-08-03

Primary Completion

2027-06-13

Completion

2027-12-13

Countries

• United Arab Emirates

Study Locations