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Yiwu Cold Knife Technique Versus Electrocision for Multiple Endometrial Polyps

NCT07737301 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 850

Last updated 2026-07-30

No results posted yet for this study

Summary

\# Clinical Trial Summary Template (Based on your endometrial polyp study)

The goal of this clinical trial is to learn if cold knife hysteroscopic polypectomy (Yiwu procedure) works to treat multiple endometrial polyps in women. It will also learn about the surgical safety of cold knife hysteroscopic polypectomy (Yiwu procedure). The main questions it aims to answer are:

Does cold knife hysteroscopic polypectomy (Yiwu procedure) achieve a 1-year postoperative recurrence rate that is non-inferior to electroresection hysteroscopic polypectomy? What intraoperative and postoperative adverse events and complications do participants experience after receiving either surgical treatment? Researchers will compare cold knife hysteroscopic polypectomy (Yiwu procedure) to standard electroresection hysteroscopic polypectomy to verify whether the cold knife technique can reduce endometrial polyp recurrence without increasing surgical risks.

Participants will:

Receive either cold knife hysteroscopic polypectomy or conventional electroresection hysteroscopic polypectomy as standardized surgery Attend clinic follow-up visits at 3, 6 and 12 months after surgery for physical examinations and transvaginal ultrasound scans Complete clinical assessment records including menstrual status, abnormal uterine bleeding symptoms, pain conditions and patient satisfaction scores throughout the 1-year follow-up period

Conditions

  • Yiwu Cold Knife Technique for Multiple Endometrial Polyps

Interventions

PROCEDURE

Cold knife hysteroscopic polypectomy (Yiwu procedure)

Endometrial polyps are removed by mechanical cutting using hysteroscopic micro-scissors or morcellators. No electrosurgical energy is used for resection or hemostasis; bleeding control relies only on mechanical compression of the wound base. No thermal injury to surrounding endometrium is permitted during the operation.

PROCEDURE

Electroresection hysteroscopic polypectomy

Endometrial polyps are excised with standard hysteroscopic electrosurgical loops. High-frequency electric current is applied for tissue cutting and intraoperative hemostasis. Thermal ablation of normal endometrial tissue outside polyp lesions is prohibited per trial protocol.

Sponsors & Collaborators

  • The Fourth Affiliated Hospital of Zhejiang University School of Medicine

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
48 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-08-01
Primary Completion
2029-06-01
Completion
2029-06-01

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07737301 on ClinicalTrials.gov