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Immune Response to PSF in Idiopathic vs Neuromuscular Scoliosis

NCT07734467 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 20

Last updated 2026-08-06

No results posted yet for this study

Summary

The objective of this study is to evaluate the immune response to posterior spinal fusion (PSF) in patients with neuromuscular scoliosis, comparing patients with idiopathic scoliosis who undergo the same procedure. This will be accomplished using serum biomarkers of immune response. Anecdotally, it appears that patients with neuromuscular scoliosis have more fluid resuscitation needs compared to patients with idiopathic scoliosis. The proposed hypothesis of this observation is that patients with neuromuscular scoliosis have a more profound immune response compared to patients with idiopathic scoliosis, which leads to a more robust systematic inflammatory response syndrome.

Conditions

  • Posterior Spinal Fusion
  • Idiopathic Scoliosis
  • Neuromuscular Scoliosis

Interventions

DIAGNOSTIC_TEST

Serum blood samples for serum biomarkers of immune response

Preoperative and postoperative blood samples using biomarkers to evaluate immune response.

Sponsors & Collaborators

  • Ambrish Patel

    lead OTHER

Principal Investigators

  • Ambrish Patel, MD · Nationwide Children's Hospital

Eligibility

Min Age
0 Years
Max Age
99 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-10-31
Primary Completion
2029-06-30
Completion
2029-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07734467 on ClinicalTrials.gov