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Finasteride and Cutibacterium

NCT07731802 · Status: NOT_YET_RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2026-07-28

No results posted yet for this study

Summary

High levels of Testosterone causes high amounts of skin bacteria (Cutibacterium Acnes) which can go into the skin during a shoulder replacement surgery and cause a terrible infection.

The goal of this experiment is to have participants take Finasteride, a medication that blocks testosterone production, for 2 weeks and evaluate the following:

* Blood levels of testosterone
* Amount of bacteria on the skin.

Participants will:

* Be assigned to take Finasteride, or a placebo (a look-alike pill with no active medicine) once daily, for 2 weeks
* Have a small sample of their blood collected and their skin swabbed with a Q-tip to determine Testosterone levels and bacteria on the skin
* Blood draw and skin testing will take place before starting Finasteride or the placebo (day 0) and at the end of the experiment (day 14).

Conditions

  • Dihydrotestosterone
  • Periprosthetic Joint Infection (PJI)
  • Cutibacterium Acnes

Interventions

DRUG

Finasteride 1 mg

Patients randomized to the experimental group will receive oral Finasteride 1 mg, taken daily, for two weeks

DRUG

Placebo Control

Patients randomized to the placebo group will receive one pill containing no active medicine, taken daily, for two weeks.

Sponsors & Collaborators

Principal Investigators

  • Corey Schiffman, MD · University of Washington

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-08-31
Primary Completion
2027-03-31
Completion
2027-08-31
FDA Drug
Yes

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07731802 on ClinicalTrials.gov