RISE: Reducing Cancer and HIV Stigma Through Empowerment

Summary

This multilevel randomized behavioral study evaluates participant- and provider-level stigma-reduction interventions in Zambia. Participant-level intervention: Women living with cervical cancer and HIV (WLC+H ) are randomized in a 2×2 factorial design of storytelling versus neutral videos and storytelling versus neutral disclosure interventions to assess effects on quality of life, anxiety, and depressive symptoms. Provider-level intervention: Healthcare workers are randomized to storytelling or neutral videos to assess changes in stigma and compassion. The study also evaluates participant -reported stigma and satisfaction with care before and after implementation of the provider intervention.

Conditions

• HIV
• Cervical Cancer Stigma

Interventions

BEHAVIORAL

Neutral Video

Participants in the control group will watch neutral videos and describe objective, non-emotional objects/events

BEHAVIORAL

Storytelling

The storytelling intervention group will watch the storytelling videos and then describe objective, non-emotional objects/events.

BEHAVIORAL

Self disclosure

Participants will watch neutral videos and then talk/write about their cancer/HIV-related experiences to themselves.

BEHAVIORAL

Combination

The combination group will watch the storytelling videos and then talk/write about their cancer/HIV-related experiences to themselves.

BEHAVIORAL

Video

Participants (healthcare workers) will watch storytelling videos in a group setting, followed by a facilitated discussion and role-playing to enhance empathy and understanding.

BEHAVIORAL

Waitlist

Participants will watch unrelated presentations in a group setting while on a waitlist. They will receive the intervention after completing the post-test.

Sponsors & Collaborators

• Cancer Diseases Hospital; University of Zambia

  collaborator UNKNOWN

• M.D. Anderson Cancer Center

  lead OTHER

Principal Investigators

• Qian Lu, MD, PHD · UT MD Anderson

Study Design

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

DOUBLE

Model

FACTORIAL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-09-01

Primary Completion

2030-05-31

Completion

2030-08-31

Countries

• United States

Study Locations