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Safety and Efficacy of Underwater Endoscopic Mucosal Resection for Type I Gastric Neuroendocrine Tumors Measuring 5-9 mm

NCT07728292 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2026-07-27

No results posted yet for this study

Summary

Study objectives:

Primary objective:

1.To determine the histologic R0 resection rate of UEMR for type I gastric NETs measuring 5-9 mm.

Secondary objectives:

To evaluate:

1. En bloc resection rate
2. Immediate and delayed adverse events
3. Procedure time
4. Histologic quality of resection (deep and lateral margins)
5. Residual disease at resection scar on surveillance endoscopy oMetachronous gastric NETs during follow-up

Conditions

  • Stomach Neuroendocrine Neoplasm

Interventions

PROCEDURE

Endoscopic mucosal resection under water

* Standard diagnostic gastroscope * Minimal insufflation followed by complete deflation of the gastric lumen * Lumen filled with normal saline to achieve complete submersion of the lesion * Optional marking for flat or ill-defined lesions * Snare capture with a 1-2 mm margin under water * Resection using standardized electrosurgical settings * Defect management (clips or coagulation) at endoscopist discretion * Retrieval of intact specimen * Specimen orientation and pinning on cork for histopathologic assessment

Sponsors & Collaborators

  • Asian Institute of Gastroenterology, India

    lead OTHER

Principal Investigators

  • Zaheer Dr Nabi, MD · AIG HOSPITALS

  • Mohan Dr Ramchandani, MD · AIG HOSPITALS

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-07-17
Primary Completion
2026-11-10
Completion
2026-12-30

Countries

  • India

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07728292 on ClinicalTrials.gov