Dendritic Cell-immunotherapy for Advanced Hepatocellular Carcinoma
NCT07726329 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 100
Last updated 2026-07-24
Summary
The prognosis of advanced hepatocellular carcinoma is poor. In this study, the eligible patients will be treated by tumor antigen-pulsed autologous dendritic cells and followed by TACE. The end points are to see tumor response and patient survival.
Conditions
- Liver Neoplasms
Interventions
- BIOLOGICAL
-
dendritic cells
autologous dendritic cell vaccination
Sponsors & Collaborators
-
Chang Gung Memorial Hospital
lead OTHER
Principal Investigators
-
Wei-Chen Lee, MD · Chang Gung Memorial Hospital
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2019-07-01
- Primary Completion
- 2028-02-29
- Completion
- 2028-02-29
Countries
- Taiwan
Study Locations
More Related Trials
-
Safety and Efficacy of dRug-ElutiNg beADs Trans-arterial chemoEmbolization for Hepatocellular Carcinoma in Taiwan
NCT03283956 ·Status: UNKNOWN
-
TACE Combined With PD-1 Knockout Engineered T Cell in Advanced Hepatocellular Carcinoma.
NCT04417764 ·Status: UNKNOWN ·Phase: PHASE1
-
Precision Cell Immunotherapy Combined With TACE in Advanced Liver Cancer
NCT02873442 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
TACE Combined with Anti-PD-1 Antibody in Patients with Advanced Hepatocellular Carcinoma
NCT04297280 ·Status: COMPLETED ·Phase: PHASE2
-
Precision Cell Immunotherapy Combined With TACE in Advanced Liver Cancer
NCT02862613 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Observation Study: Superselective Drug-Eluting Chemoembolization in Unresectable Intermediate and Advanced HCC Patients
NCT03273608 ·Status: UNKNOWN
-
DC-CIK Combined With TACE in the Treatment of Hepatocellular Carcinoma
NCT02487017 ·Status: UNKNOWN ·Phase: PHASE2
-
TACE Plus PD-1 Antibody vs TACE Alone for Unresectable HCC
NCT03782831 ·Status: WITHDRAWN ·Phase: PHASE2
-
TACE With Immune Agents for Angiogenesis in Hepatocellular Carcinoma
NCT07053202 ·Status: COMPLETED ·Phase: NA
-
The Impact on Therapeutic Effect and Tolerance of Treatment for Patients With Hepatocellular Carcinoma in Transcatheter Arterial Chemoembolization (TACE) of Dexamethasone Application: A Random, Double-blind, Controlled, Clinical Trial.
NCT02987907 ·Status: UNKNOWN ·Phase: PHASE3
-
A Retrospective Study on the Treatment of Intermediate and Advanced Liver Cancer.
NCT06205732 ·Status: RECRUITING
-
A Study of GPC3 Redirected Autologous T Cells for Advanced HCC
NCT02715362 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
TACE Plus Recombinant Human Adenovirus for Hepatocellular Carcinoma
NCT01869088 ·Status: UNKNOWN ·Phase: PHASE3
-
Efficacy Study of TACE to Treat Hepatocellular Carcinoma After Operation
NCT02631499 ·Status: UNKNOWN ·Phase: PHASE4
-
HAIC Combined With Second-line "Target Immunity" for HCC With TACE Standard Treatment Low Response or Failure
NCT05233358 ·Status: UNKNOWN ·Phase: NA
-
Precision Cell Immunotherapy Combined With TACE in Advanced Liver Cancer
NCT02862587 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
The Safety and Efficacy of Transarterial Chemoembolization (TACE) + Lenvatinib + Programmed Cell Death Protein 1 (PD-1) Antibody of Advanced Unresectable Hepatocellular Carcinoma
NCT04997850 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Adjuvant Radiotherapy Comparing TACE for Curative HCC
NCT02125396 ·Status: UNKNOWN ·Phase: PHASE3
-
Trans-catheter Arterial Embolization Combined With p53 Gene Therapy for Treatment of Advanced Hepatocellular Carcinoma
NCT02509169 ·Status: UNKNOWN ·Phase: PHASE2
-
Taiwan ACE Beads for Hepatoma Embolization Therapy
NCT02825550 ·Status: COMPLETED ·Phase: NA
-
A Prospective Observational Cohort Study on Dynamic CD8+ T-cell Profiling and Multi-omics Biomarkers for Predicting Conversion Therapy Response in Unresectable Hepatocellular Carcinoma
NCT07117279 ·Status: NOT_YET_RECRUITING
-
TACE Combined With Immune Checkpoint Inhibitors for Liver Malignant Tumors
NCT06487663 ·Status: RECRUITING ·Phase: NA
-
Combine TACE and Autologous Tcm Immunotherapy Versus TACE Alone for HCC With MVI After Radical Resection
NCT03575806 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of TAC-101 in Combination With TACE Versus TACE Alone in Asian Patients With Advanced Hepatocellular Carcinoma
NCT00756782 ·Status: WITHDRAWN ·Phase: PHASE2
-
Efficacy and Safety of TACE in Combination With ICIs for HCC: a Real-world Study
NCT04975932 ·Status: COMPLETED