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Mantram Repetition Versus Health Education for Veterans With PTSD and Chronic Pain

NCT07725588 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 170

Last updated 2026-07-27

No results posted yet for this study

Summary

Approximately 450,000 Veterans Health Administration service users have both posttraumatic stress disorder (PTSD) and chronic pain (CP); treatments that efficiently target both PTSD and CP are limited, and new interventions should address the unique needs of Veterans with PTSD/CP. Mantram Repetition Program (MRP), a meditation-based program, appears well-suited to address these high-priority VA needs. MRP has established effectiveness for treatment of PTSD, is broadly acceptable, can be learned quickly and applied flexibly. However, rigorous testing is needed for pain-related outcomes among a PTSD/CP population. The proposed study will include a randomized controlled trial comparing the efficacy of MRP for PTSD/CP to Health Education while Living with Pain among a sample of 170 Veterans with comorbid PTSD/CP. The primary outcomes will be PTSD symptoms and pain interference. Results from this study will directly inform patient care among the nearly 4% of Veterans with PTSD/CP.

Conditions

  • Stress Disorders, Post-Traumatic
  • Pain, Chronic

Interventions

BEHAVIORAL

Mantram Repetition Program for PTSD + Pain

manualized Mantram Repetition Program adapted for Veterans with PTSD and chronic pain

BEHAVIORAL

Health Education while Living with Pain

manualized health and wellness psychoeducation and discussion group

Sponsors & Collaborators

  • VA Office of Research and Development

    lead FED

Principal Investigators

  • Anne L Malaktaris · VA San Diego Healthcare System, San Diego, CA

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2027-04-01
Primary Completion
2030-04-01
Completion
2030-09-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07725588 on ClinicalTrials.gov