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Acetaminophen vs Placebo for Postoperative Analgesia After Abdominal Surgery

NCT07720791 · Status: NOT_YET_RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 1504

Last updated 2026-07-22

No results posted yet for this study

Summary

This study investigates whether oral acetaminophen, when added to standard pain management, reduces opioid use and pain after major abdominal surgery, compared to a placebo (inactive pill). Patients undergoing planned abdominal surgery under general anesthesia will be randomly assigned to receive either acetaminophen or a placebo tablet before surgery and every 6 hours afterward for 48 hours, in addition to their usual pain medication. Researchers will measure how much opioid pain medication patients need, how much pain they report, and how satisfied they are with their pain control during the first two days after surgery. The goal is to determine whether oral acetaminophen provides a genuine benefit beyond placebo in reducing opioid use while maintaining adequate pain control.

Conditions

  • Pain, Postoperative

Interventions

DRUG

Acetaminophen

Intervention 1: Acetaminophen (Type: Drug) Oral acetaminophen 1000 mg tablet, administered 30 minutes before surgery and every 6 hours postoperatively until 48 hours after surgery. Other Name(s): Paracetamol Intervention 2: Placebo (Type: Other / Drug) Oral placebo tablet, visually identical to the acetaminophen tablet, administered on the same schedule (30 minutes before surgery and every 6 hours postoperatively until 48 hours after surgery).

Sponsors & Collaborators

  • Erzurum Regional Training & Research Hospital

    collaborator OTHER_GOV

  • Konya City Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-07-15
Primary Completion
2027-07-15
Completion
2027-08-01

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Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07720791 on ClinicalTrials.gov