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Microneedling vs. 5-Fluorouracil or Steroid Injections for Hypertrophic Scars and Keloids

NCT07718269 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2026-07-22

No results posted yet for this study

Summary

The goal of this clinical trial is to learn about the efficacy and safety of microneedling-assisted 5-fluorouracil delivery in comparison with intralesional 5-fluorouracil, intralesional corticosteroid, and microneedling with saline for the treatment of pathological scars.

Conditions

  • Keloid Scars
  • Hypertrophic Scar

Interventions

PROCEDURE

Microneedling with 5-Fluorouracil

Undiluted 5-FU was applied topically after microneedling

DRUG

Intralesional 5-fluorouracil

undiluted 5-fluorouracil was applied topically

DRUG

Intralesional Triamcinolone Acetonide

Triamcinolone acetonide was administered intralesionally

PROCEDURE

Microneedling With saline

saline was applied after microneedling

Sponsors & Collaborators

  • Alexandria University

    lead OTHER

Principal Investigators

  • Shaimaa Ismail Omar, MD · Alexandria University

  • Yehia Farouk Al-Jarem, MD · Alexandria University

  • Alaa Tarek Abd El Maksoud, MBBCH · Alexandria University

  • Marwa Essawy · Alexandria University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-01-12
Primary Completion
2024-01-15
Completion
2025-03-08

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07718269 on ClinicalTrials.gov