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Plasma Exchange in Pediatric Autoimmune Encephalitis

NCT07707739 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 22

Last updated 2026-07-16

No results posted yet for this study

Summary

The aim of the study will be to compare the efficacy of daily plasma exchange (PLEX) versus alternate-day PLEX in achieving a favorable functional outcome in children with autoimmune encephalitis.

The study population will be divided into two groups, the first group will perform PLEX on consecutive days and the second one will perform it every other day. Then, A Favorable functional outcome measure defined as modified Rankin Scale (mRS) score ≤ 2. The mRS will be assessed by a blinded assessor at the end of the sessions to determine which method has superior efficacy in treatment of autoimmune encephalitis.

Conditions

  • Autoimmune Encephalitis (AE)

Interventions

PROCEDURE

Plasma exchange (PE)

Plasma exchange (PE) sessions to be done daily for Arm A

PROCEDURE

Plasma exchange (PE)

Plasma exchange (PE) sessions to be done on every other day for Arm B

Sponsors & Collaborators

  • Menoufia University

    lead OTHER

Principal Investigators

  • Hani Hamed Saad, MD, lecturer of pediatrics · Faculty of medicine, Menoufia University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
1 Month
Max Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-08-01
Primary Completion
2027-02-28
Completion
2027-03-31

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07707739 on ClinicalTrials.gov