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Silver Nanoparticle-Coated Orthodontic Brackets for Preventing Enamel Demineralization

NCT07707336 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 16

Last updated 2026-07-16

No results posted yet for this study

Summary

The goal of this clinical trial is to learn whether orthodontic brackets coated with silver nanoparticles can help prevent early damage to tooth enamel in people receiving fixed braces.

The main question it aims to answer is:

-Do silver nanoparticle-coated brackets help reduce enamel demineralization (the early stage of tooth decay) compared with standard stainless steel brackets?

Researchers will compare silver nanoparticle-coated brackets with standard stainless steel brackets. Each participant will receive both types of brackets on different teeth so that the results can be compared within the same person.

Participants will:

* Receive fixed orthodontic treatment as planned.
* Have both silver nanoparticle-coated and standard stainless steel brackets placed on different teeth.
* Attend routine orthodontic appointments.
* Have premolar teeth that were already planned for extraction as part of their orthodontic treatment removed after one month so researchers can examine the tooth enamel around the brackets.

Conditions

  • Enamel Demineralization
  • White Spot Lesions

Interventions

DEVICE

Silver Nanoparticle-Coated Stainless Steel Orthodontic Brackets

Stainless steel orthodontic brackets coated with silver nanoparticles were bonded to randomly assigned premolars during fixed orthodontic treatment and remained in place for one month before the planned extraction of the premolars for enamel evaluation.

DEVICE

Conventional Stainless Steel Orthodontic Brackets

Conventional stainless steel orthodontic brackets were bonded to the contralateral premolars during fixed orthodontic treatment and remained in place for one month before the planned extraction of the premolars for enamel evaluation.

Sponsors & Collaborators

  • Ajman University

    lead OTHER

Principal Investigators

  • Jeny M George, MDS · Ajman University

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-09-20
Primary Completion
2025-04-29
Completion
2025-05-23

Countries

  • United Arab Emirates

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07707336 on ClinicalTrials.gov