MedTrace Logo

The Role of Vitamin D and Vitamin D Receptor in Recurrent Wheezing in Children With Bronchiolitis: Immunological Association With T-lymphocyte Mitochondrial Mass

NCT07700134 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 130

Last updated 2026-07-13

No results posted yet for this study

Summary

A prospective study will be conducted involving children under 2 years of age hospitalized for bronchiolitis during the period 2025-2026. Serum levels of 25-OH vitamin D (by chemiluminescence assay), VDR gene polymorphisms (through molecular techniques), and mitochondrial mass of T lymphocytes (by flow cytometry), will be determined in patients at the acute phase of bronchiolitis and in healthy controls. The children will be followed-up for 36 months, with systematic documentation of wheezing episodes and the prognostic value of the biomarkers mentioned above for the later development of recurrent wheezing will be assessed.

This study aims to explore the associations between vitamin D levels, VDR polymorphisms and T-cell mitochondrial mass with bronchiolitis severity and the subsequent risk of wheezing episodes. It is hoped that predictive biomarkers for wheezing risk following bronchiolitis and potential therapeutic targets will be identified.

Conditions

  • Bronchiolitis Acute
  • Wheezing
  • RSV

Interventions

OTHER

No Intervention: Observational Cohort

No intervetion

Sponsors & Collaborators

  • Aghia Sophia Children's Hospital of Athens

    collaborator OTHER

  • National and Kapodistrian University of Athens

    lead OTHER

Principal Investigators

  • Tania Siahanidou, Professor · Medicine department, National and Kapodistrian University of Athens, Greece

Eligibility

Min Age
0 Days
Max Age
24 Months
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-12-01
Primary Completion
2028-12-31
Completion
2028-12-31

Countries

  • Greece

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07700134 on ClinicalTrials.gov