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Pedunculopontine Nucleus Transcranial Ultrasound Stimulation as a Treatment of Freezing of Gait in Parkinson's Disease

NCT07695233 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2026-07-10

No results posted yet for this study

Summary

This study is investigating the use of transcranial ultrasound stimulation (TUS) on the Pedunculopontine nucleus (PPN) in changing freezing of gait in people with Parkinson's disease. The PPN is noted to be involved in voluntary movements, locomotion, and muscle tone. This will be assessed by patient-reported outcomes and analyzing the gait. The study will also investigate the effects of the stimulation on the PPN and surrounding connectivity by using magnetic resonance imaging (MRI).

Conditions

  • Parkinson Disease
  • Freezing of Gait Symptoms in Parkinson Disease

Interventions

DEVICE

Excitatory Stimulation

Excitatory Stimulation to the PPN

DEVICE

Inhibitory Stimulation

Inhibitory Stimulation to the PPN

DEVICE

Sham

Sham stimulation to PPN

Sponsors & Collaborators

  • Robert Chen

    lead OTHER

Principal Investigators

  • Robert Chen, MD · University Health Network, Toronto

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-05-17
Primary Completion
2027-12-31
Completion
2028-12-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07695233 on ClinicalTrials.gov