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Intraperitoneal Dexmedetomidine Versus Magnesium as Adjuvants to Bupivacaine in Laparoscopic Cholecystectomy

NCT07693621 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2026-07-09

No results posted yet for this study

Summary

Although both dexmedetomidine and magnesium sulphate have been individually evaluated as adjuvants to local anesthetics, direct comparisons between the two agents in intraperitoneal instillation during laparoscopic cholecystectomy remain limited. Understanding their relative efficacy and safety could provide valuable guidance for optimizing perioperative analgesia in these patients.

Conditions

  • Dexmedetomidine
  • Magnesium Sulfate
  • Laparoscopic Cholecystectomy

Interventions

OTHER

Bupivacaine 100 mg + dexmedetomidine 1 µg/kg

20 ml bupivacaine + 1 µg/kg dexmedetomidine . The total volume will be adjusted to 50 mL with saline.

OTHER

Bupivacaine 100 mg + magnesium sulphate 50 mg/kg

20 ml bupivacaine + 50 mg/kg magnesium sulphate . The total volume will be adjusted to 50 mL with saline.

Sponsors & Collaborators

  • Alexandria University

    lead OTHER

Principal Investigators

  • sarah m elgamal, MD · Alexandria University

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-05-03
Primary Completion
2026-11-03
Completion
2027-01-01

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07693621 on ClinicalTrials.gov