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Topical Herbal Medicine for Chemotherapy-Induced Peripheral Neuropathy

NCT07693387 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2026-07-09

No results posted yet for this study

Summary

The goal of this clinical trial is to learn if menthol works to relieve chronic neuropathic pain and chemotherapy-induced peripheral neuropathy (CIPN). The primary objectives are to evaluate the safety and clinical efficacy of menthol-containing gloves and foot-covers, specifically whether they can improve patient-reported hypoesthesia (numbness). Secondary objectives include assessing the sustained effects on pain, dysesthesia (abnormal sensations), allodynia (touch-induced pain), and overall quality of life. Additionally, this study will include an exploratory lab analysis using blood samples to investigate potential biological markers (small extracellular vesicles and microRNA) associated with treatment responses. Participants will be asked to: Wear menthol-containing gloves and foot-covers (or shams) daily for 5 minutes per session over a 14-day period. Attend clinic visits on Days 1, 14, 21, and 28 for evaluations and tests.

Conditions

  • Chemotherapy-induced Peripheral Neuropathy (CIPN)

Interventions

DRUG

menthol-based hand and foot gloves

Participants will undergo a two-week intervention, wearing the menthol gloves for five minutes once daily.

DRUG

Sham menthol-based hand and foot gloves

Participants will undergo a two-week intervention, wearing the sham menthol gloves for five minutes once daily.

Sponsors & Collaborators

  • China Medical University, Taiwan

    collaborator OTHER

  • Taiwan Municipal An-Nan Hospital-China Medical University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-05-12
Primary Completion
2027-01-31
Completion
2027-01-31

Countries

  • Taiwan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07693387 on ClinicalTrials.gov