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Theta Burst Transcranial Focused Ultrasound as a Novel Treatment for Cervical Dystonia

NCT07690514 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 48

Last updated 2026-07-08

No results posted yet for this study

Summary

This study is a single-blinded, randomized control study that aims to recruit 48 participants. Participants will be "randomized" into one of the study arms of the study: active stimulation to GPi, active stimulation to DN, or sham stimulation. The purpose of the study is to look into the effects of LIFUS in patients with cervical dystonia. The participation will include seven study visits, at least 24 hours apart. All study visits will take place at TWH. The first visit is a screening visit. Visits 2-6 will be on consecutive days. Visit 7 will be a week from Visit 6 or from your last day of LIFUS, whichever comes first.

Conditions

  • Cervical Dystonia

Interventions

DEVICE

LIFUS - GPi Active

Bilateral thetaburst LIFUS stimulation to the globus pallidus

DEVICE

LIFUS - DN Active

Bilateral thetaburst LIFUS stimulation to dentate nucleus

DEVICE

LIFUS - Sham

Bilateral sham (placebo) LIFUS stimulation

Sponsors & Collaborators

  • Robert Chen

    lead OTHER

Principal Investigators

  • Robert Chen, MD · University Health Network, Toronto

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-11-18
Primary Completion
2028-12-31
Completion
2029-12-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07690514 on ClinicalTrials.gov