Real-World Clinical Outcomes in Relapsed/Refractory Multiple Myeloma Treated With Pomalidomide Regimens
NCT07689006 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 341
Last updated 2026-07-07
Summary
This retrospective observational study will use data from the OneOncology United States database to evaluate clinical outcomes in adults with relapsed/refractory multiple myeloma who received pomalidomide-containing or non-pomalidomide-containing treatment as second-line or third-line therapy after prior exposure to lenalidomide and a proteasome inhibitor.
Conditions
Interventions
- DRUG
-
Pomalidomide-containing regimens
Exposure to pomalidomide-containing index regimens, including daratumumab, pomalidomide, and dexamethasone (DPd) and carfilzomib, pomalidomide, and dexamethasone (KPd), administered in routine clinical practice.
- DRUG
-
Non-pomalidomide-containing regimens
Exposure to non-pomalidomide-containing index regimens, including daratumumab, lenalidomide, and dexamethasone (DRd), daratumumab, bortezomib, and dexamethasone (DVd), and daratumumab, carfilzomib, and dexamethasone (DKd), administered in routine clinical practice.
Sponsors & Collaborators
- lead INDUSTRY
Principal Investigators
-
Bristol Myers Squibb · Bristol-Myers Squibb
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2024-12-23
- Primary Completion
- 2025-03-28
- Completion
- 2025-03-28
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
A Phase 3, Multicenter, Randomized, Open-Label Study to Compare the Efficacy and Safety of Pomalidomide in Combination With Low-Dose Dexamethasone Versus High-Dose Dexamethasone in Subjects With Refractory Multiple Myeloma or Relapsed and Refractory Multiple Myeloma and Companion Study
NCT01311687 ·Status: COMPLETED ·Phase: PHASE3
-
Safety and Efficacy of Pomalidomide, Bortezomib and Low-dose Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma
NCT01734928 ·Status: COMPLETED ·Phase: PHASE3
-
Combination Study of Pomalidomide, Marizomib, and Low-Dose Dexamethasone in Relapsed and Refractory Multiple Myeloma
NCT02103335 ·Status: COMPLETED ·Phase: PHASE1
-
Comparison of Pom and Dex in Subjects With RRMM Previously Treated With Len and a PI Dara/Pom/Dex vs Pom/Dex
NCT03180736 ·Status: COMPLETED ·Phase: PHASE3
-
Study to Evaluate the Safety and Efficacy of Pomalidomide Monotherapy in Subjects With Refractory or Relapsed Refractory Multiple Myeloma
NCT01324947 ·Status: COMPLETED ·Phase: PHASE3
-
Pomalidomide, Bortezomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma
NCT01212952 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Pomalidomide in Combination With High Dose Dexamethasone and Oral Cyclophosphamide
NCT01432600 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Pomalidomide or Lenalidomide and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma Previously Treated With Lenalidomide
NCT01794039 ·Status: COMPLETED ·Phase: PHASE2
-
Evaluation of Safety of Pomalidomide in Combination With Dexamethasone (Low Dose) in Patients With Refractory or Relapsed and Refractory Multiple Myeloma
NCT01712789 ·Status: COMPLETED ·Phase: PHASE3
-
Study of Magrolimab Combinations in Patients With Relapsed/Refractory Multiple Myeloma
NCT04892446 ·Status: TERMINATED ·Phase: PHASE2
-
Pomalidomide in Gene Expression Profiling (GEP)-Defined High-risk Multiple Myeloma
NCT01177735 ·Status: COMPLETED ·Phase: PHASE2
-
Nivolumab Role in the Treatment of Patients With Refractory or Relapse Multiple Myeloma
NCT03023527 ·Status: TERMINATED ·Phase: PHASE1
-
Panobinostat and Carfilzomib in Treating Participants With Relapsed or Refractory Multiple Myeloma
NCT01301807 ·Status: COMPLETED ·Phase: PHASE1
-
Study to Determine the Maximum Tolerated Dose for the Combination of Pomalidomide, Bortezomib and Low-Dose Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma
NCT01497093 ·Status: COMPLETED ·Phase: PHASE1
-
Pomalidomide, Dexamethasone and Pegylated Liposomal Doxorubicin for Relapsed/Refractory Multiple Myeloma
NCT01541332 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Pomalidomide/Cyclophosphamide/Dexamethasone in Relapse Refractory Myeloma: Safety Profile in Mexicans
NCT03601624 ·Status: UNKNOWN ·Phase: PHASE2
-
Efficacy and Toxicity Study of Pomalidomide and Dexamethasone in Patients Who Have Relapsed After Exposure to Lenalidomide and Bortezomib
NCT02158702 ·Status: UNKNOWN ·Phase: PHASE2
-
Treatment of Relapsed/Refractory Multiple Myeloma (rrMM) With Pomalidomide in Clinical Practice
NCT02555839 ·Status: COMPLETED
-
Pomalidomide in Treating Patients With Relapsed or Refractory Waldenstrom Macroglobulinemia
NCT01198067 ·Status: TERMINATED ·Phase: PHASE1
-
Japanese Phase 1 Study to Evaluate Tolerated Dose, Safety, and Efficacy of Pomalidomide in Patients With Refractory or Relapsed and Refractory Multiple Myeloma
NCT01568294 ·Status: COMPLETED ·Phase: PHASE1
-
Study of Bortezomib and Dexamethasone With or Without Cyclophosphamide in Patients With Relapsed or Not Controllable Multiple Myeloma
NCT00813150 ·Status: COMPLETED ·Phase: PHASE3
-
Pomalidomide in Combination With Low-dose Dexamethasone or Pomalidomide in Combination With Low-dose Dexamethasone and Daratumumab in Subjects With Relapsed or Refractory Multiple Myeloma Following Lenalidomide-based Therapy in the First or Second Line Setting
NCT01946477 ·Status: COMPLETED ·Phase: PHASE2
-
Pomalidomide and Dexamethasone in Treating Patients With Relapsed or Refractory Primary Central Nervous System Lymphoma or Newly Diagnosed or Relapsed or Refractory Intraocular Lymphoma
NCT01722305 ·Status: COMPLETED ·Phase: PHASE1
-
Study of Pomalidomide, Oral Dexamethasone and Very Low-dose Cyclophosphamide in Patients With Refractory Multiple Myeloma Who Have Received Lenalidomide and Bortezomib
NCT04243109 ·Status: TERMINATED ·Phase: PHASE2
-
Pomalidomide-Cyclophosphamide-Dexamethasone (PCD) Versus Pomalidomide-Dexamethasone (PD) in Relapse or Refractory Myeloma
NCT03143049 ·Status: UNKNOWN ·Phase: PHASE3