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Etiologic Diagnosis Algorithm in Infective Endocarditis

NCT07682389 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 128

Last updated 2026-07-02

No results posted yet for this study

Summary

The goal of this study is to evaluate the impact of a diagnostic algorithm combining culture-based and molecular methods on the frequency of etiotropic antibiotic therapy prescription within 14 days of diagnosis of infective endocarditis

Conditions

  • Infective Endocarditis
  • Microbiology

Interventions

DIAGNOSTIC_TEST

Molecular tests (PCR, sequencing)

PCR and PCR with consequent sequencing of the blood (or tissue) will be performed in addition to the cultural methods in the experimental study arm

DIAGNOSTIC_TEST

Standard Clinical Practice

Patients receive standard care with analysis of microorganisms in at least 2 or more separate blood culture sets and from cardiac tissue (if surgical treatment is performed); molecular test results are blinded for the treating physician

Sponsors & Collaborators

  • Federal State Budgetary Institution of the Central Research Institute of Epidemiology of Rospotrebnadzor

    collaborator UNKNOWN

  • City Clinical Hospital Named After S. S. Yudin, Moscow, Russian Federation

    collaborator UNKNOWN

  • City Clinical Hospital №67 Named After L. A. Vorokhobova, Moscow, Russian Federation

    collaborator UNKNOWN

  • A.N. Bakulev National Medical Research Center for Cardiovascular Surgery of the Russian Ministry of Health, Moscow, Russian Federation

    collaborator UNKNOWN

  • I.M. Sechenov First Moscow State Medical University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-01-20
Primary Completion
2027-02-04
Completion
2027-02-20

Countries

  • Russia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07682389 on ClinicalTrials.gov