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Intraoperative Intravenous Lidocaine for Pain After Laparoscopic Appendectomy

NCT07678385 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 225

Last updated 2026-07-01

No results posted yet for this study

Summary

This randomized, double-blind, placebo-controlled clinical trial evaluated whether intraoperative intravenous lidocaine infusion improves postoperative analgesia and recovery in patients undergoing laparoscopic appendectomy. The primary objective was to assess postoperative pain intensity and opioid consumption. Secondary outcomes included postoperative nausea and vomiting, time to bowel function recovery, length of hospital stay, plasma lidocaine concentrations, and adverse events.

Conditions

  • Post Operative Pain, Acute
  • Laparoscopic Appendectomy

Interventions

DRUG

Lidocaine (drug)

Intravenous lidocaine administered as a bolus followed by continuous infusion during laparoscopic appendectomy according to the study protocol.

DRUG

Normal Saline Placebo Infusion

Intravenous isotonic saline administered using the same infusion schedule as the active treatment to maintain blinding.

Sponsors & Collaborators

  • Hospital Universitario de Caracas

    lead OTHER

Principal Investigators

  • JOSEPH A VERAZA, MD · sociedad medica joseph veraza

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-02-01
Primary Completion
2025-01-01
Completion
2025-01-01

Countries

  • Venezuela

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07678385 on ClinicalTrials.gov