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Atropine Eye Drops for Watery Eyes (Excessive Tearing)

NCT07676981 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 18

Last updated 2026-06-30

No results posted yet for this study

Summary

The goal of this clinical trial is to learn if low-dose atropine eye drops work to reduce excessive watery eyes (epiphora) in adults. It will also learn about the safety of the eye drops.

The main questions it aims to answer are:

Do the eye drops reduce how often participants have watery eyes? What medical problems do participants have when taking the eye drops?

Researchers will compare two strengths of the eye drops (0.005% and 0.01%) to see whether one works better than the other and whether the lower strength works as well as the higher one.

Participants will:

* Use the assigned eye drops in the affected eye(s) for one week
* Visit the clinic twice for checkups and eye tests
* Receive a follow-up phone call about two weeks after starting, to check on any symptoms

Conditions

  • Epiphora

Interventions

DRUG

Atropine ophthalmic solution

The interventions are two low doses of atropine ophthalmic solution

Sponsors & Collaborators

  • Rehan Ahmed

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-06-30
Primary Completion
2026-07-31
Completion
2026-07-31
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07676981 on ClinicalTrials.gov