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An Investigation of Topical Ophthalmic Low-Dose Atropine on Pupil Size and Accommodation

NCT07674966 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2026-06-30

No results posted yet for this study

Summary

The goal of this clinical study is to learn about the short-term physiological effects of low-dose atropine in healthy volunteers. The study seeks to examine three questions related to low-dose topically applied ophthalmic atropine:

1. Does applying two drops of 0.01% atropine sulfate solution cause the same clinical effects as one drop of 0.02% atropine?
2. How quickly do the pupil responses and accommodative amplitudes recover following a dose of 0.01% atropine, 0.02% atropine, and 0.05% atropine?
3. Does applying a single drop of 0.02% atropine sulfate solution cause the same clinical effects in participants with light vs. dark iris colors? Participants will have their pupil size and accommodative status measured at appropriate intervals to answer the questions above.

Conditions

  • Myopia

Interventions

DRUG

Atropine 0.01% Ophthalmic Solution

Two drops of 0.01% atropine sulfate solution

DRUG

Atropine 0.02% Ophthalmic Solution

One drop of 0.02% atropine sulfate solution

DRUG

Atropine 0.05% Ophthalmic Solution

Atropine 0.05% Ophthalmic Solution

Sponsors & Collaborators

Principal Investigators

  • Sarah E Singh, OD, PhD · University of California, Berkeley

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-03-16
Primary Completion
2022-10-09
Completion
2022-10-09
FDA Drug
Yes

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07674966 on ClinicalTrials.gov